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isocyanic acid

structure

Also Known As:

hydrogen isocyanide

Networked: 9 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Cyanates: 131
  - isocyanic acid: 9

Experts

1.	Gillery, Philippe: 2 articles (01/2016 - 01/2014)
2.	Jaisson, Stéphane: 2 articles (01/2016 - 01/2014)
3.	Alam, Khursheed: 1 article (12/2020)
4.	Arif, Zarina: 1 article (12/2020)
5.	Badar, Asim: 1 article (12/2020)
6.	Islam, Shireen Naaz: 1 article (12/2020)
7.	Qais, Faizan Abul: 1 article (12/2020)
8.	Gillery, P: 1 article (03/2018)
9.	Gorisse, L: 1 article (03/2018)
10.	Jacolot, P: 1 article (03/2018)

Related Diseases

1.	Atherosclerosis 10/07/2014 - "Exposure to gas-phase isocyanic acid (HNCO) has been previously shown to be associated with the development of atherosclerosis, cataracts and rheumatoid arthritis. " 05/31/2011 - "Further, our measurements of aqueous solubility show that HNCO is highly soluble, as it dissociates at physiological pH. Exposure levels > 1 ppbv provide a direct source of isocyanic acid and cyanate ion (NCO(-)) to humans at levels that have recognized health effects: atherosclerosis, cataracts, and rheumatoid arthritis, through the mechanism of protein carbamylation. " 01/01/2014 - "Carbamylation is due to the binding of isocyanic acid on the α-NH2 extremity of proteins or amino acids, or on ε-NH2 lysine groups, generating homocitrulline, a potential biomarker in atherosclerosis. "
2.	Cataract (Cataracts) 03/01/2016 - "Annual exposure to isocyanic acid was close to 1ppb, the concentration considered to be sufficient to enhance risks for cardiovascular diseases and cataracts. " 10/07/2014 - "Exposure to gas-phase isocyanic acid (HNCO) has been previously shown to be associated with the development of atherosclerosis, cataracts and rheumatoid arthritis. " 05/31/2011 - "Further, our measurements of aqueous solubility show that HNCO is highly soluble, as it dissociates at physiological pH. Exposure levels > 1 ppbv provide a direct source of isocyanic acid and cyanate ion (NCO(-)) to humans at levels that have recognized health effects: atherosclerosis, cataracts, and rheumatoid arthritis, through the mechanism of protein carbamylation. "
3.	Chronic Renal Insufficiency 12/01/2020 - "The results indicate that in chronic kidney disease patients, elevated levels of isocyanic acid (formed from urea) may modify the albumin structure and lead to its conversion into amyloidogenic aggregates, thus accelerating kidney damage." 03/01/2018 - "Chronic kidney disease (CKD) and diabetes mellitus are two diseases that accelerate protein molecular ageing through carbamylation and glycation reactions, characterized by the binding of urea-derived isocyanic acid and of sugars on proteins, respectively. "
4.	Rheumatoid Arthritis 10/07/2014 - "Exposure to gas-phase isocyanic acid (HNCO) has been previously shown to be associated with the development of atherosclerosis, cataracts and rheumatoid arthritis. " 05/31/2011 - "Further, our measurements of aqueous solubility show that HNCO is highly soluble, as it dissociates at physiological pH. Exposure levels > 1 ppbv provide a direct source of isocyanic acid and cyanate ion (NCO(-)) to humans at levels that have recognized health effects: atherosclerosis, cataracts, and rheumatoid arthritis, through the mechanism of protein carbamylation. "
5.	Renal Insufficiency (Renal Failure) 01/01/2016 - "As isocyanic acid mainly originates from the spontaneous dissociation of urea, carbamylation rate is increased during renal failure. "

Related Drugs and Biologics

1.	Urea (Carbamide)
2.	Proteins (Proteins, Gene)
3.	Biomarkers (Surrogate Marker)
4.	Lysine (L-Lysine)
5.	Indicators and Reagents (Reagents)
6.	Hemoglobins (Hemoglobin)
7.	DNA (Deoxyribonucleic Acid)
8.	Cyanates
9.	Amino Acids
10.	Albumins