HOME PRODUCTS COMPANY CONTACT FAQ

Research Dictionary Pharma

Sign Up FREE or Login

gitoxin

an isomer of digoxin; the OH group which is in the C16 position while it is in the C12 position for Digoxin

Also Known As:

16alpha-gitoxin

Networked: 6 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Polycyclic Compounds: 6
- Fused-Ring Compounds
  - Steroids: 70059
    - Cardanolides
      - Cardiac Glycosides: 1002
        Cardenolides: 137
        Digoxin: 4157
        gitoxin: 6
        Digitalis Glycosides: 147
        Digoxin: 4157
        gitoxin: 6
Carbohydrates: 22023
- Glycosides: 2119
  - Cardiac Glycosides: 1002
    - Digitalis Glycosides: 147
      - Digoxin: 4157
        gitoxin: 6

Experts

1.	Ayuso, María Jesús: 1 article (08/2003)
2.	Cortés, Felipe: 1 article (08/2003)
3.	López-Lázaro, Miguel: 1 article (08/2003)
4.	Martín-Cordero, Carmen: 1 article (08/2003)
5.	Navarro, Eduardo: 1 article (08/2003)
6.	Palma De La Peña, Nieves: 1 article (08/2003)
7.	Pastor, Nuria: 1 article (08/2003)
8.	Toro, María Victoria: 1 article (08/2003)

Related Diseases

1.	Low Cardiac Output 07/01/1981 - "After intravenous administration of 1 mg digoxin or gitoxin, only gitoxin was observed to have an inotropic effect leading to significant improvement of the low cardiac output in these patients."
2.	Heart Failure 07/01/1981 - "The present paper deals with the comparative hemodynamic effect of digoxin and gitoxin on nine patients suffering from heart failure. " 07/01/1981 - "Contrasting effect on cardiac output of digoxin and gitoxin in humans during congestive heart failure." 01/01/1988 - "In a therapeutic study, 120 inpatients suffering from congestive heart failure were treated with a daily maintenance dose of 0.3 mg pengitoxin (penta-acetyl-gitoxin) over several weeks or months. "
3.	Cardiotoxicity 02/01/1977 - "Cardiotonic effects and cardiotoxicities of three furanosteroidal glycosides were compared with those of standard cardiac glycosides (digitoxin, gitoxin, etc.). "
4.	Sexually Transmitted Diseases (Sexually Transmitted Disease) 06/01/1994 - "Doses of 16 alpha-gitoxin which induce a maximum abbreviation of STI or QT did neither provoke a distinct decrease in heart rate nor cardiac disturbances. " 06/01/1994 - "The glycoside plasma level was measured simultaneously to the pharmacodynamic parameters by a radioimmunoassay, 16 alpha-gitoxin abbreviated dose-dependently the STI (LVET and QS2) for 30 (i.v.) or 15 ms (per os) and the QT interval for 35 ms. A mean plasma concentration of 401 ng/ml was measured 15 minutes after the i.v. injection of 5 mg and a mean plasma level of 402 ng/ml was measured 1 hour after the oral intake of 10 mg 16 alpha-gitoxin as an aqueous-ethanolic solution. "
5.	Neoplasms (Cancer) 08/01/2003 - "Gitoxigenin and gitoxin were evaluated in the SRB assay using the three human cancer cell lines, showing IC50 values in the 0.13 - 2.8 microM range, with the renal adenocarcinoma cancer cell line (TK-10) being the most sensitive one. "

Related Drugs and Biologics

1.	Digoxin (Digitek)
2.	PENTA
3.	pentaacetylgitoxin
4.	Glycosides
5.	Solutions
6.	Proscillaridin
7.	Digitoxin
8.	Cardiotonic Agents (Cardiac Stimulants)
9.	Cardiac Glycosides
10.	gitoxigenin

Related Therapies and Procedures

1.	Intravenous Administration
2.	Oral Administration