ferulic acid (sodium ferulate)

widely distributed in small amounts in plants

Also Known As:

sodium ferulate; 3-(4-hydroxy-3-methoxyphenyl)-2-propenoic acid; 4-hydroxy-3-methoxycinnamic acid; 8,8'-diferulic acid; cis-ferulic acid; ferulic acid, (E)-isomer; ferulic acid, (Z)-isomer; ferulic acid, monosodium salt; trans-ferulic acid

Networked: 738 relevant articles (84 outcomes, 171 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Carboxylic Acids: 973
  - Carbocyclic Acids
    - Cinnamates: 48
      - Coumaric Acids: 128
        ferulic acid: 738

Experts

1.	Koh, Phil-Ok: 11 articles (02/2015 - 01/2012)
2.	Huang, Xi: 7 articles (01/2022 - 05/2006)
3.	Wang, Hui: 7 articles (12/2021 - 09/2009)
4.	Ren, Ping: 6 articles (01/2022 - 05/2006)
5.	Chen, Li: 5 articles (01/2022 - 02/2015)
6.	Li, Li: 5 articles (01/2022 - 12/2009)
7.	Mancuso, Cesare: 5 articles (01/2021 - 09/2006)
8.	Zhang, Jing: 5 articles (01/2021 - 02/2012)
9.	Cheng, Chin-Yi: 5 articles (01/2019 - 01/2008)
10.	Liu, Zhifeng: 5 articles (08/2017 - 10/2011)

Related Diseases

1.	Inflammation (Inflammations) 01/01/2021 - "Ferulic Acid Ameliorates Hepatic Inflammation and Fibrotic Liver Injury by Inhibiting PTP1B Activity and Subsequent Promoting AMPK Phosphorylation." 01/01/2017 - "Corrigendum to "Ferulic Acid Induces Th1 Responses by Modulating the Function of Dendritic Cells and Ameliorates Th2-Mediated Allergic Airway Inflammation in Mice"." 01/01/2015 - "Ferulic Acid Induces Th1 Responses by Modulating the Function of Dendritic Cells and Ameliorates Th2-Mediated Allergic Airway Inflammation in Mice." 10/01/2018 - "Corrigendum to "An in vitro inflammation model to study the Nrf2 and NF-κB crosstalk in presence of ferulic acid as modulator" doi: 10.1016/j.imbio.2017.10.046 [Immunobiology (2018) Vol 223; 349-355]." 04/01/2018 - "An in vitro inflammation model to study the Nrf2 and NF-κB crosstalk in presence of ferulic acid as modulator."
2.	Brain Ischemia (Cerebral Ischemia) 03/01/2015 - "Ferulic acid ameliorates nerve injury induced by cerebral ischemia in rats." 03/01/2015 - "This study was designed to investigate the protective effect of ferulic acid (FA) on nerve injury induced by cerebral ischemia. " 06/01/2013 - "This study investigated whether ferulic acid modulates the expression of CRMP-2 and its upstream targets, Akt and GSK-3β, in focal cerebral ischemia. " 01/01/2019 - "Ferulic Acid Exerts Anti-apoptotic Effects against Ischemic Injury by Activating HSP70/Bcl-2- and HSP70/Autophagy-Mediated Signaling after Permanent Focal Cerebral Ischemia in Rats." 11/01/2012 - "Ferulic acid plays a neuroprotective role in cerebral ischemia. "
3.	Body Weight (Weight, Body) 09/26/2017 - "In the present study, hypertrophic growth of fast skeletal myofibers was observed in adult zebrafish after ferulic acid administration for 30 days, being reflected in increased body weight, body mass index (BMI), and muscle mass, along with an enlarged cross-sectional area of myofibers. " 09/15/2012 - "To study the radiation protection, mice were administered with ferulic acid intraperitoneally (i.p) (50 mg/kg body weight.), once daily for five consecutive days. " 09/01/2004 - "Two different doses of ferulic acid, 20 mg/kg body weight and 40 mg /kg body weight were used for the study. " 04/20/2020 - "In addition, ferulic acid group rats received ferulic acid at a dose of 20 mg/kg body weight (bwt) intragastrically daily for 12 weeks. " 12/01/2019 - "Furthermore, treatment with 20 or 30 mg/kg body weight ferulic acid significantly reduced the pixel intensity and significantly increased the peak load and ultimate stiffness. "
4.	Carcinogenesis 08/01/2015 - "Thus, the results of the present study indicate ferulic acid has potential against UVB-induced carcinogenesis in the Swiss albino mice. " 01/01/2003 - "In this study, we investigated the modifying effects of a novel geranylated derivative, ethyl 3-(4'-geranyloxy-3'-methoxyphenyl)-2-propenoate (EGMP), synthesized from ferulic acid on tongue carcinogenesis initiated with 4-nitroquinoline 1-oxide (4-NQO). " 05/01/2009 - "Our results thus demonstrate that orally administered ferulic acid has potent suppressing effect on cell proliferation during DMBA-induced skin carcinogenesis. " 01/01/2003 - "We have previously observed the inhibitory effect of ferulic acid on rat tongue carcinogenesis. " 04/01/2001 - "A ferulic acid derivative, ethyl 3-(4'-geranyloxy-3-methoxyphenyl)-2-propenoate, as a new candidate chemopreventive agent for colon carcinogenesis in the rat."
5.	Alzheimer Disease (Alzheimer's Disease) 07/05/2016 - "We previously reported the protective effects of ferulic acid administration against two animal models of Alzheimer's disease (AD): intracerebroventricular (i.c.v.) injection of Aß1-42 in mice and APP/PS1 mutant transgenic mice. " 07/05/2016 - "Protective effects of a dimeric derivative of ferulic acid in animal models of Alzheimer's disease." 10/05/2021 - "Ferulic Acid in Animal Models of Alzheimer's Disease: A Systematic Review of Preclinical Studies." 01/01/2023 - "Neuroprotective Properties of Ferulic Acid in Preclinical Models of Alzheimer's Disease: A Systematic Literature Review." 09/08/2022 - "Recent Advances in the Neuroprotective Properties of Ferulic Acid in Alzheimer's Disease: A Narrative Review."

Related Drugs and Biologics

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2.	Antioxidants
3.	Proteins (Proteins, Gene)
4.	gamma-oryzanol
5.	Ascorbic Acid (Vitamin C)
6.	Lipids
7.	Acids
8.	Resveratrol
9.	Gallic Acid
10.	Vitamin E

Related Therapies and Procedures

1.	Therapeutics
2.	Oral Administration
3.	Punctures
4.	Ligation
5.	Lasers (Laser)