|1.||Ni, Yicheng: 28 articles (06/2015 - 09/2003)|
|2.||Olivo, Malini: 24 articles (09/2012 - 05/2002)|
|3.||de Witte, Peter A M: 20 articles (07/2012 - 01/2002)|
|4.||Verbruggen, Alfons: 16 articles (05/2015 - 12/2003)|
|5.||Roskams, Tania: 15 articles (07/2012 - 01/2002)|
|6.||Agostinis, Patrizia: 13 articles (09/2015 - 03/2002)|
|7.||de Witte, Peter: 13 articles (09/2015 - 12/2003)|
|8.||Zhang, Jian: 13 articles (06/2015 - 09/2011)|
|9.||Fedorocko, Peter: 13 articles (01/2010 - 07/2002)|
|10.||Chen, Feng: 12 articles (06/2015 - 05/2006)|
03/01/2006 - "In contrast, delivery of hypericin as a solution resulted in dramatically improved tumor to normal tissue ratios and a relatively fast elimination from the body. "
04/01/2011 - "Our final objective will be to evaluate the potential of hypericin fluorescence imaging to improve the efficacy of cervical cancer diagnosis performed on fixed cell smears obtained from liquid-based cytology. "
11/01/2004 - "Hypericin shows promise in cancer and human immunodeficiency virus therapy but may harm individuals taking St. John's Wort extracts (for mild to moderate depression). "
09/28/2012 - "The exact cellular target for the potent anti-cancer agent hypericin has not yet been determined; this thus encourages the application of computational chemistry tools to be employed in order to provide insights that can be employed in further drug development studies. "
04/01/2011 - "Diagnosis of cancer based on hypericin fluorescence imaging has been successfully assessed in several clinical trials. "
02/01/2014 - "Radioiodinated hypericin: its biodistribution, necrosis avidity and therapeutic efficacy are influenced by formulation."
02/01/2015 - "Hypericin (HYP) has been found avid to necrosis in small animal studies. "
02/01/2015 - "Radiopharmaceutical study on Iodine-131-labelled hypericin in a canine model of hepatic RFA-induced coagulative necrosis."
07/01/2013 - "The purpose of this study was to investigate the biodistribution and pharmacokinetics of radioiodinated hypericin (Hyp), a naturally occurring compound, after intravenous (i.v.) injection in a rat model of liver and muscle necrosis (n = 42), and evaluate its necrosis affinity. "
06/01/2015 - "These results suggest that (131)I-protohypericin is a promising necrosis avid compound with a weaker aggregation tendency compared with hypericin and it may have a broad application in imaging and oncotherapy. "
|3.||Phototoxic Dermatitis (Phototoxicity)
09/01/1997 - "Furthermore, phototoxicity may be different after application of pure hypericin, since some constituents in the plant extract may exhibit protective effects."
11/01/2006 - "This study was conducted to determine whether the phototoxicity of hypericin in HaCaT keratinocytes could be attenuated by H. "
03/01/2005 - "In this study, we have synthesized several new methyl helianthrone derivatives and compared their phototoxicity with that of hypericin. "
08/05/2013 - "Hypericin encapsulated in solid lipid nanoparticles: phototoxicity and photodynamic efficiency."
03/01/2012 - "Evaluation of hypericin-loaded solid lipid nanoparticles: physicochemical properties, photostability and phototoxicity."
|4.||Melanoma (Melanoma, Malignant)
06/01/2012 - "Depigmentation in melanomas increases the efficacy of hypericin-mediated photodynamic-induced cell death."
05/29/2008 - "This in vitro study analyses the phototoxic effect of UVA (400-315 nm) - activated hypericin in human pigmented and unpigmented melanomas and immortalised keratinocytes and melanocytes. "
10/01/2009 - "Melanomas display increased cytoprotection to hypericin-mediated cytotoxicity through the induction of autophagy."
05/29/2008 - "We show that an exposure to 1 microM UVA-activated hypericin does not bring about cell death, while 3 microM activated hypericin induces a necrotic mode of cell death in pigmented melanoma cells and melanocytes and an apoptotic mode of cell death in non-pigmented melanoma cells and keratinocytes. "
08/01/1996 - "Photodynamic-induced cytotoxicity by hypericin (HYP) was studied on three human melanoma cell lines: one pigmented cell line (G361) and two amelanotic cell lines (M18 and M6). "
|5.||Urinary Bladder Neoplasms (Bladder Cancer)
02/01/2015 - "A phase IIA dose-finding study of PVP-hypericin fluorescence cystoscopy for detection of nonmuscle-invasive bladder cancer."
09/01/2012 - "Our study has unraveled one of the many factors contributing to the selective uptake of hypericin in bladder cancer. "
11/01/2008 - "The goal of the present clinical study is to investigate whether using new water soluble hypericin (PVP-hypericin) as a fluorescent dye improves bladder cancer detection and diagnosis. "
09/01/2007 - "This study suggests that the fluorescence intensity profiles of hypericin in bladder cells can potentially provide an automated quantitative means of early bladder cancer diagnosis."
12/01/2003 - "In this study we have evaluated the use of hypericin ex vivo urine fluorescence cytology as a non-invasive method for detecting early bladder cancers. "
|2.||Photosensitizing Agents (Photosensitizers)
|5.||Transferrin (beta 2 Transferrin)
|8.||Blood Proteins (Serum Proteins)
|1.||Photochemotherapy (Photodynamic Therapy)
|5.||Heterologous Transplantation (Xenotransplantation)