1,1-diphenyl-2-picrylhydrazyl

A diphenyl picrate; the ability to decolorize this stable radical indicates reactivity of tested compounds (Banda, Anal Chem 46:1772-7 1974)

Also Known As:

1,1-DPPH; 1,1-diphenyl-2-picrylhydrazil; 2,2'-diphenyl-1-picrylhydrazyl; 2,2-diphenyl-1-picrylhydrazyl; DPPH cpd; DPPH-1,1; alpha,alpha-diphenyl-beta-picrylhydrazyl; diphenyl-p-picrylhydrazyl

Networked: 156 relevant articles (6 outcomes, 13 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Aromatic Hydrocarbons: 291
      - Benzene Derivatives: 17
        Phenols: 677
        Nitrophenols: 18
        Picrates
        1,1-diphenyl-2-picrylhydrazyl: 156
        Biphenyl Compounds: 7
        1,1-diphenyl-2-picrylhydrazyl: 156
- Nitro Compounds: 66
  - Nitrophenols: 18
    - Picrates
      - 1,1-diphenyl-2-picrylhydrazyl: 156

Experts

1.	Tokuda, Harukuni: 5 articles (12/2014 - 06/2002)
2.	Dos Santos, Edson Lucas: 4 articles (01/2018 - 01/2014)
3.	de Picoli Souza, Kely: 4 articles (01/2018 - 01/2014)
4.	Akihisa, Toshihiro: 4 articles (12/2014 - 03/2013)
5.	Ferreira, Isabel C F R: 3 articles (12/2019 - 02/2007)
6.	Fitsiou, Eleni: 3 articles (09/2019 - 01/2015)
7.	Pappa, Aglaia: 3 articles (09/2019 - 01/2015)
8.	Yasukawa, Ken: 3 articles (12/2014 - 08/2013)
9.	Shetty, Kalidas: 3 articles (02/2013 - 08/2009)
10.	Carvalho, Márcia: 3 articles (01/2010 - 04/2009)

Related Diseases

1.	Neoplasms (Cancer) 12/01/2022 - "The in vitro cancer preventive action was evaluated by doing the 2,2-diphenyl-1-picrylhydrazyl test. " 07/26/2021 - "Compounds 9 and 10 showed moderate cytotoxic activity against a panel of cancer cell lines (PC-3, HCT-15, MDA-MB-231, ACHN, NCI-H23, NUGC-3), with the GI50 values ranging from 1.1 µM to 3.6 µM, whereas 1 displayed a weak 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity without cytotoxicity against all tested cell lines." 06/01/2021 - "All the isolated compounds (1-8) were evaluated for their 2,2-diphenyl-1-picrylhydrazyl (DPPH) scavenging capacity and cytotoxicity in vitro against three human cancer cell lines including SK-LU-1, MCF7, and HT-29 cell lines. " 08/01/2013 - "Their 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical-scavenging activities and cytotoxic activities against four human cancer cell lines were also evaluated. " 11/01/2011 - "Additionally, 2,2-diphenyl-1-picrylhydrazyl (DPPH) and SO radical scavenging and cytotoxic activities against three cancer and a noncancerous cell lines of both extract were also tested using the MTT method. "
2.	Hemolysis 10/21/2020 - "Also, CsADMND was observed to possess a good ROS scavenging property, hemocompatibility and pro-angiogenic potential as demonstrated by 2,2-diphenyl-1-picrylhydrazyl (DPPH), haemolysis and chick chorioallantoic membrane (CAM) assay, respectively. " 11/06/2002 - "The reducing powers, the 2,2-diphenyl-1-picrylhydrazyl (DPPH) scavenging activities, the amount of total phenolic compounds, the inhibitory effect on FeCl(2)/H(2)O(2) (Fenton reaction system)-induced DNA damage, and the inhibitory effect on erythrocyte hemolysis of an oolong tea water extract (OTE) were evaluated in the present study. " 05/24/2023 - "The antioxidant activity was assessed by the ability to scavenge 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical and to inhibit H2O2-induced oxidative hemolysis of human erythrocytes. " 11/15/2017 - "The antioxidant capacity of STP II-1 was analyzed by monitoring both the scavenging rate of the 2,2-diphenyl-1-picrylhydrazyl free radical and inhibition rate of H2O2-induced erythrocyte hemolysis." 04/01/2016 - "The total content of flavonoid compounds in mulberry fruit was 187.23 mg/g dried materialFEM showed a strong antioxidant effect, especially in 2,2-diphenyl-1-picrylhydrazyl scavenging activity and reducing powerMouse red blood cell hemolysis induced by H2O2 was significantly inhibited by FEM in a dose- and time-dependent mannerThe inhibition percentage at high concentration of FEM was 45.51%, 39.36%, and 42.78% for mouse's liver, mitochondrial, and microsomes, respectively. "
3.	Colonic Neoplasms (Colon Cancer) 04/01/2013 - "Compared to xanthohumol (1), metabolite 2 is a better 2,2'-diphenyl-1-picrylhydrazyl (DPPH) radical scavenger, while 2 and 3 have stronger antiproliferative activity against the human HT-29 colon cancer cell line." 06/01/2009 - "The results showed that the grape extract presents a strong antiradical activity in the in vitro 2,2-diphenyl-1-picrylhydrazyl radical assay and protects against reactive oxygen species production in human colon adenocarcinoma cells (Caco-2). " 03/01/2005 - "Both 1 and 2 induced apoptosis in SW-480 colon cancer cells and displayed antioxidant activity in the 1,1-diphenyl-2-picrylhydrazyl (DPPH) assay (IC(50) = 64 and 38.7 microM, respectively). " 05/10/2020 - "The size of Cur/ALG-GANPs ranged between 10 ± 0.3 nm and 190 ± 0.1 nm and the zeta potential was -15 ± 0.2 mV. The antioxidant study of Cur/ALG-GANPs exhibited effective radical scavenging capacity for 1,1-diphenyl-2-picrylhydrazyl (DPPH) at concentrations that ranged between 30 and 500µg/mL. Cytotoxicity was performed using MTT assay to measure their potential in inhibiting the cell growth and the result demonstrated a significant anticancer activity of Cur/ALG-GANPs against human liver cancer cells (HepG2) than in colon cancer (HT29), lung cancer (A549) and breast cancer (MCF7) cells. " 11/01/2003 - "Theograndin II (2) displayed antioxidant activity (IC(50) = 120.2 microM) in the 1,1-diphenyl-2-picrylhydrazyl (DPPH) free-radical assay, as well as weak cytotoxicity in the HCT-116 and SW-480 human colon cancer cell lines with IC(50) values of 143 and 125 microM, respectively. "
4.	Hepatocellular Carcinoma (Hepatoma) 08/01/2012 - "The aqueous and butanolic extracts exhibited better 2,2-diphenyl-1-picrylhydrazyl scavenging and cytotoxic activities in hepatoma cells than in immortalized hepatocytes. " 01/01/2016 - "The study also established an optimal formulation method based on screening the synthesized flavonosomes with respect to their size, charge, polydispersity index, morphology, drug-carrier interaction, antioxidant potential through in vitro 1,1-diphenyl-2-picrylhydrazyl kinetics, and cytotoxicity evaluation against human hepatoma cell line (HepaRG). " 01/01/2015 - "The antioxidant activity and cytotoxic action against the hepatoma adenocarcinoma cell line HepG2 of the essential oil and its main components were further evaluated by the 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay and by the sulforhodamine B (SRB) assay, respectively. " 09/05/2019 - "The juice demonstrated significant antioxidant activity against the free radical 2,2-diphenyl-1-picrylhydrazyl (DPPH) and modest antiproliferative potential against four human cancer cells lines and one murine: mammary adenocarcinoma MCF-7, hepatocellular carcinoma HepG2 and colon adenocarcinomas Caco2, HT-29, as well as murine colon carcinoma CT26. " 03/01/2023 - "These six isolates were evaluated for their cytotoxic activities against human leukemia HL-60, human lung adenocarcinoma A549, human hepatoma SMMC-7721, human breast cancer MCF-7, human colon cancer SW480, and paclitaxel-resistant A549 (A549/Taxol) cell lines, for their antioxidant properties using the 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging assay, and for their differentiation effects on nerve growth factor (NGF)-mediated neurite outgrowth in rat pheochromocytoma PC12 cells. "
5.	Edema (Dropsy) 12/09/2021 - "The total phenolic content in the extract was 106.31 mg GAE/g and free radical scavenging activity against 2,2-diphenyl-1-picrylhydrazyl evaluated as IC50 was 0.298 mg/mL. The tested extract dose-dependently decreased the paw edema in rats, suggesting its potent anti-inflammatory property. " 11/09/2023 - "Radical scavenging activity was assessed by 2,2-diphenyl-1-picrylhydrazyl (DPPH) and hydrogen peroxide (H2O2) assays, while anti-inflammatory potential was evaluated via xylene-induced ear edema and carrageenan-induced paw edema models. " 05/01/2013 - "Preliminary screening of the compounds involved scavenging hydroxyl radicals and 2,2-diphenyl-1-picrylhydrazyl (DPPH(⋅)), croton oil-induced ear edema in mice, and analysis of the mRNA expression of adhesion molecules in ECs. " 01/01/2016 - "Ethnolic extracts of fruiting body and mycelia showed 88%, 85%, 71%, and 85%, 65%, 70% 2,2-diphenyl-1-picrylhydrazyl, hydroxyl (DPPH) and 2,2'-azinobis (3-ethyl benzothiazolin-6-sulfonic acid) (ABTS) radical-scavenging activities, respectively, at a concentration of 1000 µg/mL. The anti-inflammatory activity was determined using carrageenan- and formalin- induced paw edema models. " 11/01/2017 - "It was then evaluated for its in-vitro antioxidant activity against 1,1-diphenyl-2-picrylhydrazyl (DPPH), hydrogen peroxide (H2O2) and hydroxyl (OH) radical assays as well as in-vivo anti-inflammatory potential against carrageenan-induced paw edema model in rats. "

Related Drugs and Biologics

1.	Antioxidants
2.	Free Radicals
3.	2,2'-azobis(2-amidinopropane) (ABAP)
4.	Malondialdehyde (Propanedial)
5.	2,2'- azino- di- (3- ethylbenzothiazoline)- 6- sulfonic acid (ABTS)
6.	Hydroxyl Radical
7.	Enzymes
8.	Hydrogen Peroxide (Hydroperoxide)
9.	hydroxide ion
10.	Carrageenan

Related Therapies and Procedures

1.	Therapeutics