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isopentenyl pyrophosphate (isopentenyl diphosphate)

substrate for isopentenyl pyrophosphate isomerase; RN given refers to unlabeled cpd; a nonpeptide mycobacterial antigen that stimulates gamma delta T cells
Also Known As:
isopentenyl diphosphate; isopentenyl pyrophosphate, 4-(14)C-labeled; diphosphoric acid mono(3-methyl-3-butenyl) ester
Networked: 32 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Experts

1. Mönkkönen, Jukka: 3 articles (03/2010 - 12/2009)
2. Morita, Craig T: 2 articles (11/2015 - 05/2007)
3. Wang, Hong: 2 articles (11/2015 - 05/2007)
4. Herrmann, Thomas: 2 articles (01/2014 - 06/2009)
5. Unge, Torsten: 2 articles (02/2012 - 05/2011)
6. Björkelid, Christofer: 2 articles (02/2012 - 05/2011)
7. Jones, T Alwyn: 2 articles (02/2012 - 05/2011)
8. Bergfors, Terese: 2 articles (02/2012 - 05/2011)
9. Mowbray, Sherry L: 2 articles (02/2012 - 05/2011)
10. Pelkonen, Jukka: 2 articles (01/2010 - 12/2009)

Related Diseases

1. Lymphoma (Lymphomas)
2. Necrosis
3. Neoplasms (Cancer)
4. Malaria
01/01/2014 - "The apicoplast is considered to be a promising source of malaria-specific targets, and its main function during intraerythrocytic stages is to provide the isoprenoid precursor isopentenyl diphosphate, which can be used for phenotype-based screens to identify compounds targeting this organelle. "
08/01/2009 - "The 2C-methylerythritol 4-phosphate (MEP) pathway for the biosynthesis of isopentenyl pyrophosphate and its isomer dimethylallyl pyrophosphate, which are the precursors of isoprenoids, is present in plants, in the malaria parasite Plasmodium falciparum and in most eubacteria, including pathogenic agents. "
02/01/2012 - "A number of pathogens, including the causative agents of tuberculosis and malaria, synthesize the essential isoprenoid precursor isopentenyl diphosphate via the 2-C-methyl-D-erythritol 4-phosphate (MEP) pathway rather than the classical mevalonate pathway that is found in humans. "
05/01/2011 - "A number of pathogens, including the causative agents of tuberculosis and malaria, synthesize isopentenyl diphosphate via the 2-C-methyl-D-erythritol 4-phosphate (MEP) pathway rather than the classical mevalonate pathway found in humans. "
12/11/2014 - "Important pathogens such as Mycobacterium tuberculosis and Plasmodium falciparum, the causative agents of tuberculosis and malaria, respectively, and plants, utilize the 2C-methyl-D-erythritol 4-phosphate (MEP, 5) pathway for the biosynthesis of isopentenyl diphosphate (1) and dimethylallyl diphosphate (2), the universal precursors of isoprenoids, while humans exclusively utilize the alternative mevalonate pathway for the synthesis of 1 and 2. This distinct distribution, together with the fact that the MEP pathway is essential in numerous organisms, makes the enzymes of the MEP pathway attractive drug targets for the development of anti-infective agents and herbicides. "
5. Tuberculosis (Tuberculoses)

Related Drugs and Biologics

1. indolepropanol phosphate (IPP)
2. T-Cell Antigen Receptors (T-Cell Receptor)
3. Interleukin-12 (IL 12)
4. Cytokines
5. Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
6. Interleukin-2 (IL2)
7. Mevalonic Acid (Mevalonate)
8. zoledronic acid (zoledronate)
9. farnesyl pyrophosphate (farnesyl diphosphate)
10. Terpenes (Terpenoids)

Related Therapies and Procedures

1. Immunotherapy