propylene dichloride

01/01/2016 - "This study aimed to evaluate the relationship between cumulative exposure to 1,2-dichloropropane (1,2-DCP) and incidence risk of cholangiocarcinoma among workers in the offset proof-printing section of a small printing company in Osaka, Japan. "
01/01/2023 - "1,2-Dichloropropane (1,2-DCP) is recognized as the causative chemical of occupational cholangiocarcinoma in printing workers in Japan. "
10/01/2021 - "Recent epidemiological studies reported cases of cholangiocarcinoma in workers exposed to 1,2-dichloropropane (1,2-DCP) in an offset proof printing factory in Japan. "
01/01/2020 - "1,2-Dichloropropane (1,2-DCP) is recognized as the causative agent for cholangiocarcinoma among offset color proof-printing workers in Japan. "
01/01/2016 - "Relationship between cumulative exposure to 1,2-dichloropropane and incidence risk of cholangiocarcinoma among offset printing workers."

09/01/2023 - "As part of a systematic review of the non-cancer and cancer hazards of propylene dichloride (PDC), with a focus on potential carcinogenicity in workers following inhalation exposures, we determined that a mode of action (MOA)-centric framing of cancer effects was warranted. "
05/01/2015 - "1,2-Dichloropropane (1,2-DCP) has recently been reclassified from not classifiable as to its carcinogenicity to humans (Group 3) to carcinogenic to humans (Group 1) by the International Agency for Research on Cancer. "
08/01/1986 - "There was some evidence of carcinogenicity for male and female B6C3F1 mice exposed to 1,2-dichloropropane, as indicated by increased incidences of hepatocellular neoplasms, primarily adenomas. "
01/15/2021 - "The results show that the container coating had highest cancer risk (2.29 × 10-6-5.53 × 10-6) exceeding the safe limit of 1.0 × 10-6, while non-cancer risk of all workshops was lower than acceptable level of 1. Ethylbenzene and 1,2-dichloropropane should be targeted for priority removal during the container coating process in attempt to reduce adverse health effect on the occupational painters. "
01/01/2020 - "The International Agency for Research on Cancer classified 1,2-dichloropropane (1,2-DCP) as a human carcinogen in 2016. "

07/01/1991 - "1. Biochemical changes in male, Wistar rats, treated with different doses of 1,2-dichloropropane (50-500 mg kg-1 body weight), were investigated at the end of a 4-week treatment and after a 4-week recovery period. "
08/01/1986 - "Under the conditions of these 2-year gavage studies, there was no evidence of carcinogenicity for male F344/N rats receiving 62 or 125 mg/kg. For female rats there was equivocal evidence of carcinogenicity in that 250 mg/kg 1,2-dichloropropane caused a marginally increased incidence of adenocarcinomas in the mammary gland; these borderline malignant lesions occurred concurrent with decreased survival and reduced body weight gain. "
08/01/1986 - "The current 8-hour time-weighted-average concentration to which workers may be exposed to is 75 ppm. Carcinogenesis studies of 1,2-dichloropropane (<99% pure) were conducted by administering the chemical in corn oil by gavage to groups of 50 female F344/N rats and 50 male and 50 female B6C3F1 mice at doses of 125 or 250 mg/kg body weight and to groups of 50 male F344/N rats at doses of 62 or 125 mg/kg body weight. "

08/01/1986 - "The current 8-hour time-weighted-average concentration to which workers may be exposed to is 75 ppm. Carcinogenesis studies of 1,2-dichloropropane (<99% pure) were conducted by administering the chemical in corn oil by gavage to groups of 50 female F344/N rats and 50 male and 50 female B6C3F1 mice at doses of 125 or 250 mg/kg body weight and to groups of 50 male F344/N rats at doses of 62 or 125 mg/kg body weight. "
08/01/1986 - "NTP Toxicology and Carcinogenesis Studies of 1,2-Dichloropropane (Propylene Dichloride) (CAS No. 78-87-5) in F344/N Rats and B6C3F1 Mice (Gavage Studies)."

10/01/2020 - "A confirmatory study of printers enhanced suspicion of 1,2-dichloropropane as a risk for biliary tract cancer. "