desthiobiotin (dethiobiotin)

RN given refers to cpd without isomeric designation; structure

Also Known As:

dethiobiotin; desthiobiotin, (4R-cis)-isomer; desthiobiotin, (cis)-(+-)-isomer; 5-methyl-2-oxo-4-imidazolidinehexanoic acid

Networked: 6 relevant articles (0 outcomes, 0 trials/studies)

1.	Fang, Bin: 2 articles (06/2016 - 02/2016)
2.	Haura, Eric B: 2 articles (06/2016 - 02/2016)
3.	Kim, Jae-Young: 2 articles (06/2016 - 02/2016)
4.	Koomen, John M: 2 articles (06/2016 - 02/2016)
5.	Abell, Andrew D: 1 article (11/2021)
6.	Avery, Thomas: 1 article (11/2021)
7.	Booker, Grant W: 1 article (11/2021)
8.	Bruning, John B: 1 article (11/2021)
9.	Gaiser, Birgit I: 1 article (11/2021)
10.	Hodgkinson-Bean, James: 1 article (11/2021)

1.	Small Cell Lung Carcinoma (Small Cell Lung Cancer) 02/01/2016 - "To overcome hurdles in identifying key kinases in small cell lung cancer (SCLC), we integrated a target-agnostic phenotypic screen of kinase inhibitors with target identification using activity-based protein profiling (ABPP) in which a desthiobiotin-ATP probe was used. "
2.	Tuberculosis (Tuberculoses) 11/19/2021 - "Mycobacterium tuberculosis dethiobiotin synthase (MtDTBS) is a crucial enzyme involved in the biosynthesis of biotin in the causative agent of tuberculosis, M. "
3.	Neoplasms (Cancer) 12/15/2016 - "Following engraftment of desthiobiotin onto the surface of MSN, a streptavidin complex was generated, which was functionalized with biotin-modified hyaluronic acid (HA) to enable controlled drug release at cancer cells expressing HAase. "
4.	Neoplasm Metastasis (Metastasis) 11/05/2021 - "To assess systematically the regulatory roles of these proteins in melanoma metastasis, we employed a targeted chemoproteomic method, which relies on the application of stable isotope-labeled desthiobiotin-GTP acyl phosphate probes in conjunction with scheduled multiple-reaction monitoring (MRM), for profiling quantitatively the GTP-binding proteins. "
5.	Mesothelioma 01/01/2018 - "Desthiobiotin-Streptavidin-Affinity Mediated Purification of RNA-Interacting Proteins in Mesothelioma Cells."

1.	Proteins (Proteins, Gene)
2.	Streptavidin
3.	Biotin (Vitamin H)
4.	Adenosine Triphosphate (ATP)
5.	Mitogen-Activated Protein Kinase Kinases (MEKs)
6.	Proteome
7.	GTP-Binding Proteins (G-Protein)
8.	RNA (Ribonucleic Acid)
9.	Phosphotransferases (Kinase)
10.	Phosphates (Orthophosphate)