daidzein

11/01/1996 - "Daidzein was less effective in reducing both tumor incidence and multiplicity. "
04/01/2016 - "This study was conducted to investigate the mechanism of action involved in the anti-cancer activity of daidzein and identification of cancer specific micro-environment as therapeutic target of this secondary metabolite derived from soy. "
09/01/2015 - "In the present study, the in vitro cytotoxicity of daidzein was evaluated in human BEL-7402, A549, HeLa, HepG-2 and MG-63 cancer cell lines. "
05/01/2009 - "In the present study hitherto unknown effects of one of the well known isoflavonoids, daidzein, has been evaluated on its chemo-preventive action against breast cancers in pre-pubertal rats. "
12/01/2021 - "Eight novel ERβ selective daidzein analogues (NCE1-8) were synthesized and their anti-cancer activity was evaluated by in vitro and in vivo methods. "

12/01/2022 - "Daidzein supplementation improved fecundity in sows via modulation of ovarian oxidative stress and inflammation."
01/01/2022 - "Via interaction with AT1R and MasRs, daidzein improved glomerulosclerosis, oxidative stress, and inflammation in UUO-OVX rats. "
10/15/2020 - "In conclusion, these data indicate that daidzein ameliorates LPS-induced hepatocyte injury by inhibiting inflammation and oxidative stress."
10/15/2020 - "Daidzein ameliorates LPS-induced hepatocyte injury by inhibiting inflammation and oxidative stress."
01/01/2023 - "E2 and Daidzein significantly inhibited inflammation infiltration and histopathological injury in thoracic aorta in the rat model with CLP. "

10/01/2009 - "A significant reduction in breast cancer risk in Japanese-American women was associated with the highest compared with the lowest quartile excretion of urinary daidzein (OR, 0.41; 95% CI, 0.19-0.89; P(trend), 0.005). "
03/15/2020 - "The aim of this study was to investigate the inhibition of daidzein or/and regular exercise on breast cancer and to reveal the potential biological mechanisms. "
02/01/2021 - "Human breast cancer cells MCF-7 were found to be sensitive to Daidzein treatment, with an IC50 value of 50µM. "
03/15/2020 - "These results suggested that regular exercise combined with daidzein may explore a candidate way to prevent and treat the breast cancer."
03/15/2020 - "BALB/c mice pretreated with regular exercise training for 20 days (15 m/min, 60 min/d) were orthotopically transplanted with mouse breast cancer cells (4T1), and then treated with daidzein (145 mg/kg) by gavage for another 22 days. "

08/28/2014 - "These studies provide support for exploring the therapeutic efficacy of daidzein derivatives for the treatment of osteoporosis. "
01/01/2023 - "This study demonstrated that daidzein alleviates OVX-induced osteoporosis by promoting H-type vessels formation in cancellous bone, which then promotes bone formation. "
01/01/2023 - "Micro-CT showed inhibiting caveolin-1with daidzein alleviated OVX-induced osteoporosis and osteogenesis suppression. "
01/01/2023 - "Daidzein alleviates osteoporosis by promoting osteogenesis and angiogenesis coupling."
09/01/2010 - "These findings indicate that daidzein treatment stimulates thyroid C cells, increase trabecular bone mass, and decrease bone turnover in Orx middle-aged rats, which is the model of male osteoporosis."

12/01/2021 - "Daidzein with methyl substitution at R or R1 position exhibited more ERβ selectivity and could be considered as lead molecules for anti-prostate cancer activity."
08/01/2017 - "Only daidzein concentrations were inversely associated with risk of prostate cancer. "
08/01/2002 - "Is daidzein non-metabolizer a high risk for prostate cancer? "
03/25/2009 - "With the MTT test, most treatments were effective in inhibiting prostate cancer cell growth at a low dose of 5 and 10 mug/mL. In cell cycle analysis, the fractions of aglycon, a mixture of acetylglucoside and aglycon, as well as genistein and a combination of genistein and daidzein standards exhibited a high G2/M ratio for LNCaP, as did the acetylglucoside, genistein and a combination of genistein and daidzein standards for PC-3. "
12/01/2021 - "Novel daidzein molecules exhibited anti-prostate cancer activity through nuclear receptor ERβ modulation, in vitro and in vivo studies."