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acetylstrophanthidin
structure
Also Known As:
acetylstrophantindin; 3 beta,5,14,19-tetrahydroxy-5 beta-card-20(22)- enolide 19-acetate
Networked:
31
relevant articles (
1
outcomes,
3
trials/studies)
Relationship Network
Bio-Agent Context: Research Results
Polycyclic Compounds: 6
Fused-Ring Compounds
Steroids: 70059
Cardanolides
Cardiac Glycosides: 1002
Cardenolides: 137
Strophanthins: 181
Strophanthidin: 78
acetylstrophanthidin: 31
Related Diseases
1.
Myocardial Infarction
02/01/1970 - "
1 wk later in the healing phase of myocardial infarction, tolerance to acetylstrophanthidin returned to normal and left ventricular performance was improved by this drug.
"
08/01/1993 - "
The reflex chronotropic response to arterial baroreceptor stimulation was assessed in 29 patients with uncomplicated acute myocardial infarction in control conditions (72-96 h after symptom onset) and 30 min after acetylstrophanthidin administration.
"
08/01/1993 - "
We evaluated the effects of acetylstrophanthidin on baroreflex sensitivity in patients soon after an acute myocardial infarction.
"
08/01/1993 - "
Effects of acetylstrophanthidin on baroreflex sensitivity in patients with acute myocardial infarction.
"
12/01/1982 - "
Peripheral arterial and venous responses to acetylstrophanthidin in patients with acute myocardial infarction.
"
2.
Ischemia
07/01/1988 - "
Exposure to acetylstrophanthidin (4-5 x 10(-7) M) during the final 10 min of ischemia increased alpha iNa to 19.9 +/- 3.8 mM (n = 5), which was unchanged at 5 min of reperfusion.
"
11/01/1986 - "
Interaction of ischemia and reperfusion with subtoxic concentrations of acetylstrophanthidin in isolated cardiac ventricular tissues: effects on mechanisms of arrhythmia.
"
04/01/1975 - "
As a prelude to a study of severe ischemic heart failure, the therapeutic response of the ischemic ventricle to epinephrine and acetylstrophanthidin in nontoxic doses was determined in 24 intact anesthetized dogs undergoing a first episode of acute regional ischemia.
"
12/01/1977 - "
In five dogs, prior alpha adrenergic receptor blockade with phenoxybenzamine prevented the rise in coronary vascular resistance with acetylstrophanthidin during ischemia.
"
12/01/1977 - "
The present study evaluates the effects of i.v. acetylstrophanthidin and digoxin on coronary vascular resistance during acute global ischemia in 29 dogs anesthetized with chloralose and urethane.
"
3.
Heart Failure
12/01/1982 - "
The peripheral arterial and venous responses to rapidly active acetylstrophanthidin (rather than the much slower digitalis) were studied in patients with acute myocardial infarction without congestive heart failure.
"
04/01/1975 - "
As a prelude to a study of severe ischemic heart failure, the therapeutic response of the ischemic ventricle to epinephrine and acetylstrophanthidin in nontoxic doses was determined in 24 intact anesthetized dogs undergoing a first episode of acute regional ischemia.
"
12/01/1993 - "
To study the changes in myocardial digitalis binding sites in heart failure, we measured myocardial ouabain binding sites, Na-K-adenosinetriphosphatase (ATPase) activity, and ventricular muscle mechanical responses to acetylstrophanthidin in dogs with right-heart failure (RHF) produced by tricuspid avulsion and pulmonary artery constriction.
"
11/01/1975 - "
Atrial muscles were maintained at 36-37 degrees C with warmed Tyrode's solution and were stimulated at frequencies of 30 or 60/min. Depolarization to resting potentials of approximately -50 mv was noted (1) after excessive stretch was applied, (2) in muscles obtained from cats in overt right heart failure, and (3) during exposure of the muscles to excessive concentrations of acetylstrophanthidin or lidocaine.
"
4.
Cardiac Arrhythmias (Arrythmia)
11/01/1986 - "
Interaction of ischemia and reperfusion with subtoxic concentrations of acetylstrophanthidin in isolated cardiac ventricular tissues: effects on mechanisms of arrhythmia.
"
01/01/1988 - "
We conclude that an intracoronary bolus of low-dose lidocaine can suppress acetylstrophanthidin-induced ventricular arrhythmia.
"
01/01/1988 - "
We investigated whether intracoronary lidocaine can suppress ventricular arrhythmia induced by acetylstrophanthidin, a rapidly acting digitalislike agent.
"
01/01/1988 - "
The effect of intracoronary lidocaine infusion on acetylstrophanthidin-induced ventricular arrhythmia in dogs.
"
05/01/1976 - "
1 The tendency of a given oral dose of digoxin to induce cardiac dysrhythmia was determined indirectly at various times after its administration to eight conscious dogs by measurement of the intravenous dose of acetylstrophanthidin necessary to induce toxic changes in the ECG.
"
5.
Cardiotoxicity
11/01/1977 - "
3. Digoxin reduced the amount of acetylstrophanthidin required to produce electrocardiographic evidence of cardiotoxicity.
"
05/01/1973 - "
Cardiac toxicity of ouabain and acetylstrophanthidin: influence of afferent denervation.
"
03/01/1964 - "
EFFECT OF QUINIDINE AND PROCAINE AMIDE UPON ACETYLSTROPHANTHIDIN CARDIOTOXICITY.
"
Related Drugs and Biologics
1.
Ouabain (G Strophanthin)
2.
Digoxin (Digitek)
3.
Chloralose
4.
Urethane (Ethyl Carbamate)
5.
Epinephrine (Adrenaline)
6.
Adenosine Triphosphatases (ATPase)
7.
Lidocaine (Xylocaine)
8.
Adrenergic Agents (Adrenergic Drugs)
9.
Quinidine (Chinidin)
10.
Procainamide (Procan)
Related Therapies and Procedures
1.
Intravenous Infusions
2.
Denervation