chloropyramine

01/01/2018 - "In this study, molecular modelling guided structural modifications have been introduced to the chloropyramine C4 scaffold to improve its activity in breast cancer cell lines. "
01/01/2018 - "The discovery of new and more potent chloropyramine (C4) analogues for the potential treatment of invasive breast cancer."
11/08/2016 - "Pharmacologic induction of SASH1 by chloropyramine treatment of breast cancer warrants further preclinical and clinical investigation."
11/08/2016 - "Chloropyramine has previously been shown to have anti-tumour activity in breast cancer in part through modulation of FAK signalling, a pathway also regulated by SASH1. "
11/08/2016 - "SASH1 mediates sensitivity of breast cancer cells to chloropyramine and is associated with prognosis in breast cancer."

06/10/2014 - "Previously, we reported that small molecule chlorpyramine hydrochloride (C4) specifically targets the interaction between FAK and VEGFR3 and exhibits anti-tumor efficacy. "
09/01/1963 - "[ON THE EFFECT OF SUPRASTIN ON TUMORS IN MICE]."
09/01/1963 - "[THE EFFECT OF SUBCUTANEOUSLY ADMINISTERED SUPRASTIN ON ASCITES TUMOR STRAINS IN MICE]."
08/13/2009 - "Chloropyramine hydrochloride reduced tumor growth as a single agent, while concomitant administration with doxorubicin had a pronounced synergistic effect. "
08/15/1963 - "[THE EFFECT OF PERITUMORALLY ADMINISTERED ISOTONIC SUPRASTIN SOLUTION ON MOUSE TUMORS]."

01/01/2015 - "In the current study, we examined the effects of a small molecule, chloropyramine hydrochloride (C4), designed to disrupt the FAK-VEGFR-3 interaction, upon cellular attachment, migration, and survival in two human neuroblastoma cell lines. "
01/01/2015 - "In addition, treatment of murine xenografts with chloropyramine hydrochloride decreased neuroblastoma xenograft growth. "

08/01/1994 - "The oedema disk technique was used to study the effects of orally administered H1-receptor antagonists (cetirizine, chloropyramine, clemastine, cyproheptadine, dimethindene, loratadine, mequitazine and terfenadine) on the inflammation induced with capsaicin or croton oil in the mouse ear, and the effect of topically applied dimethindene maleate gel on the inflammation induced with croton oil in the mouse ear. "

01/01/1964 - "[SUPRASTIN IN ANAPHYLACTIC SHOCK]."
05/01/1989 - "During anaphylactic shock absorption of pipolphen and to a lesser degree of suprastin tends to increase. "
03/01/1988 - "[Characteristics of dimedrol, pipolfen and suprastin absorption from the small intestine of rats in systemic anaphylactic shock]."
05/01/1994 - "Experience showed that multicomponent premedication including a complex of antihistaminic agents (diphenylhydramine hydrochloride++pipolphen+suprastin) and corticosteroids is a measure of reliable prevention of anaphylactic reactions both in primary and repeated xenosplenoperfusions. "