4-chloroaniline

01/01/2015 - "P-chloroaniline (PCA) was one of the first substances described in the context of acquired methemoglobinemia. "
02/01/2009 - "The seemingly innocuous dermal and inhalation exposure to p-chloroaniline dust can lead to life-threatening methemoglobinemia. "
01/01/2015 - "P-chloroaniline poisoning causing methemoglobinemia: a case report and review of the literature."
03/01/1991 - "p-Chloroaniline, capable of being formed by hydrolysis of this diarylsulfonylurea, is known to induce methemoglobinemia and/or hemolytic anemia. "
09/01/1992 - "Metabolic formation of p-chloroaniline thus appears to be a plausible explanation for the methemoglobinemia and anemia found to be dose-limiting toxicities of sulofenur in Phase I trials."

03/01/1992 - "The aim of this study was to elucidate the time courses of amounts of urinary p-chloroaniline (p-CA) metabolites during acute poisoning and to establish a suitable method for biological monitoring of exposure to p-CA. Urinary p-CA metabolites which were previously identified in a patient with acute p-CA poisoning were determined quantitatively over time during admission of a patient by high-performance liquid chromatography (HPLC) and by the colorimetric method of diazo-positive metabolites (DPM). "
03/01/1992 - "[Amounts of urinary metabolites of p-chloroaniline and their half lives in a patient with acute poisoning]."
01/01/1992 - "Previously, we identified by gas chromatography/mass spectrometry (GC/MS) urinary metabolites of p-chloroaniline (p-CA) in a patient with acute p-CA poisoning. "
11/01/1991 - "[Identification of urinary metabolites in a patient of acute poisoning by p-chloroaniline]."
01/01/2015 - "P-chloroaniline poisoning causing methemoglobinemia: a case report and review of the literature."

01/01/1979 - "Although splenic lesions were observed in male rats, no mean body weight depression relative to controls was associated with administration of p-chloroaniline to these animals. "
01/01/1979 - "Mean body weight depression, in relation to controls, was observed in high dose female rats and dosed mice of both sexes, indicating that the concentration of p-chloroaniline administered to these animals may have approximated the maximum tolerated concentrations. "
10/01/1990 - "p-Chloroaniline (PCA) was administered as PCA hydrochloride in water by gavage to groups of ten Fischer 344 rats and ten B6C3F1 mice of each sex for 13 wk. The doses, calculated as PCA rather than the hydrochloride salt, were 0, 5, 10, 20, 40 or 80 mg PCA/kg body weight/day for rats and 0, 7.5, 15, 30, 60 or 120 mg/kg body weight/day for mice. "
03/01/1998 - "In comparative 13-week studies conducted to determine the structure-toxicity relationships of o-, m-, and p-chloroaniline, groups of 10 male and 10 female F344/N rats and B6C3F1 mice were administered 0, 10, 20, 40, 80, or 160 mg o- or m-chloroaniline per kilogram body weight in dilute hydrochloric acid by gavage. "

07/01/1989 - "Conclusions: Under the conditions of these 2-year water gavage studies, there was clear evidence of carcinogenic activity of p-chloroaniline hydrochloride for male F344/N rats, as indicated by increased incidences of uncommon sarcomas of the spleen. "
07/01/1989 - "There was equivocal evidence of carcinogenic activity of p-chloroaniline hydrochloride for female F344/N rats, as indicated by the presence of uncommon sarcomas of the spleen in one mid and one high dose animal and the increased incidence of pheochromocytomas of the adrenal gland. "
07/01/1984 - "Splenic fibrosis and sarcomas in F344 rats fed diets containing aniline hydrochloride, p-chloroaniline, azobenzene, o-toluidine hydrochloride, 4,4'-sulfonyldianiline, or D & C red No. 9."

07/01/1989 - "Toxicology and carcinogenesis studies of p-chloroaniline (greater than 99% pure) were conducted by administering p-chloroaniline hydrochloride in water by gavage to groups of F344/N rats and B6C3F1 mice of each sex for 16 days, 13 weeks, or 2 years. "
07/01/1989 - "NTP Toxicology and Carcinogenesis Studies of para-Chloroaniline Hydrochloride (CAS No. 20265-96-7) in F344/N Rats and B6C3F1 Mice (Gavage Studies)."