chloroprocaine (Nesacaine)

10/01/2020 - "Patients randomized to chloroprocaine versus saline reported significantly improved median pain scores 30 min after the femoral block (2.0 vs. 5.5, P = 0.0001). "
01/01/2018 - "Among the 32 patients who received chloroprocaine, 17 had improved pain scores documented after instillation. "
01/01/2018 - "Intraperitoneal chloroprocaine may be useful as part of a multimodal approach to managing intraoperative pain during cesarean delivery."
06/01/2017 - "After an initial bolus, a continuous infusion of 1.5% of 2-chloroprocaine was initiated to achieve satisfactory pain relief throughout an uneventful vaginal delivery."
01/01/2016 - "We retrospectively reviewed our experience over 4 years with continuous chloroprocaine epidural infusions in neonates, infants, and children with a focus on the postoperative management of pain. "

01/01/2004 - "Spinal chloroprocaine provides adequate potency with reliable regression, seemingly without concerns of transient neurologic symptoms, and hence an appealing profile for outpatient surgery. "
06/01/1980 - "Persistent neurologic deficit and adhesive arachnoiditis following intrathecal 2-chloroprocaine injection."
10/01/2014 - "Chloroprocaine has been demonstrated to be associated with a lower risk of transient neurologic symptoms compared with lidocaine. "
06/01/2014 - "The short-acting local anesthetic 2-chloroprocaine has an appropriate length of action for short outpatient procedures with a very low risk of transient neurologic symptoms. "
01/01/2004 - "Hyperbaric spinal 2-chloroprocaine is effective and has an anesthetic profile appropriate for use in the surgical outpatient over the dose range of 30-60 mg without signs of transient neurologic symptoms. "

12/01/2020 - "Recent studies have investigated the safety and efficacy of preservative-free chloroprocaine for use in spinal anesthesia, but few provide the incidence of adverse events such as urinary retention and transient neurologic symptoms. "
12/01/2020 - "In 6 months of use at our institution, chloroprocaine provided safe and effective spinal anesthesia for short orthopedic procedures, with no incidence of transient neurologic symptoms, neuropraxia, or urinary retention."
12/01/2016 - "However, as chloroprocaine has a shorter duration and a lower risk of TNS and urinary retention, the indications for prilocaine remain to be defined."
06/01/2013 - "Moreover, the preservative free 2-chloroprocaine solution showed a very low risk of urinary retention and transient neurological symptoms when compared with bupivacaine and lidocaine. "

01/01/2017 - "Continuous wound infusion with chloroprocaine in a pig model of surgical lesion: drug absorption and effects on inflammatory response."
07/01/2004 - "After obtaining written informed consent, 52 patients (aged 18-65 yr, American Society of Anesthesiologists physical status I-III) were randomly assigned to receive either an INB or GA under standardized protocols (INB = 3% 2-chloroprocaine + HCO3 + epinephrine 1:300000, followed by propofol sedation; GA = 12.5 mg dolasetron, propofol induction, followed by laryngeal mask airway insertion and desflurane for maintenance; 0.25% bupivacaine for wound infiltration). "
12/01/2008 - "Studies published during the past 12 months have provided results for several 'take home messages', which include use of perioperative celecoxib improves short-term and long-term postoperative outcome; perineural catheter analgesia is feasible and safe at home; small incision cholecystectomy is quicker to perform and has no disadvantages when compared with laparoscopic technique; 2-chloroprocaine appears to be the drug of choice for spinal anesthesia; simple regional anesthesia techniques such as wound infiltration and intraarticular local anesthetics are safe and effective; Society of Ambulatory Anesthesia guidelines for managing postoperative nausea and vomiting recommend use of regional anesthesia techniques and use of certain drugs (and avoidance of others) if general anesthesia is chosen. "

12/01/2008 - "Studies published during the past 12 months have provided results for several 'take home messages', which include use of perioperative celecoxib improves short-term and long-term postoperative outcome; perineural catheter analgesia is feasible and safe at home; small incision cholecystectomy is quicker to perform and has no disadvantages when compared with laparoscopic technique; 2-chloroprocaine appears to be the drug of choice for spinal anesthesia; simple regional anesthesia techniques such as wound infiltration and intraarticular local anesthetics are safe and effective; Society of Ambulatory Anesthesia guidelines for managing postoperative nausea and vomiting recommend use of regional anesthesia techniques and use of certain drugs (and avoidance of others) if general anesthesia is chosen. "