bufotalin

01/01/2023 - "Bufotalin ameliorated allergic rhinitis symptoms in AR mice by restoring Tregs in lymph node."
01/01/2023 - "Bufotalin ameliorates ovalbumin-induced allergic rhinitis by restoring the Tregs."

02/01/2018 - "Furthermore, bufotalin demonstrated in vivo anticancer efficacy in a tumor-bearing nude mice model, where bufotalin effectively inhibited Eca-109 xenograft tumor growth in a time- and dose-dependent manner, through activation of the p53 signaling pathway. "
10/05/2012 - "These results indicate that bufotalin has a promising potential to become a novel anti-cancer agent for the treatment of liver cancer with multidrug resistance."
04/01/2019 - "Bufotalin, as an active component of Venenum bufonis, has been proven to exhibit antitumor effects in cancer types. "
02/01/2018 - "In addition, treatment of ESCC cells with bufotalin markedly activated tumor protein p53 (p53) phosphorylation. "
02/01/2018 - "However, bufotalin and bufalin exhibited lower toxicity towards Het-1A human esophageal squamous cells, indicating their high selectivity towards cancer cells. "

01/14/2009 - "In this study, bufotalin-induced apoptosis in human hepatocellular carcinoma Hep 3B cells was investigated. "
10/05/2012 - "In our search for anti-hepatoma constituents in Venenum Bufonis, bufotalin, bufalin, telocinobufagin and cinobufagin were obtained. "
01/01/2022 - "Meanwhile, the ChanSu active components (e.g., telocinobufagin, bufotalin, bufalin, cinobufotalin, and cinobufagin) exert great antitumor activity in many cancers, such as breast cancer, colorectal cancer, hepatocellular carcinoma and esophageal squamous cell carcinoma. "

01/01/2012 - "Bufalin, bufotalin and gamabufotalin, key bufadienolides, significantly sensitize human breast cancer cells with differing ER-alpha status to apoptosis induction by the TNF-related apoptosis-inducing ligand (TRAIL). "
01/01/2022 - "Meanwhile, the ChanSu active components (e.g., telocinobufagin, bufotalin, bufalin, cinobufotalin, and cinobufagin) exert great antitumor activity in many cancers, such as breast cancer, colorectal cancer, hepatocellular carcinoma and esophageal squamous cell carcinoma. "
04/01/2011 - "In the current study, we found that bufalin, bufotalin and gamabufotalin, key members of bufadienolides isolated from a traditional Chinese medicine ChanSu, significantly potentiated human breast cancer cells with different status of ER-alpha to apoptosis induction of TRAIL, as evidenced by enhanced Annexin V/FITC positive cells (apoptotic cells), cytoplasmic histone-associated-DNA-fragments, membrane permeability transition (MPT), caspases activation and PARP cleavage. "

08/15/2014 - "In this study, we examined the potential anti-osteoblastoma function of bufotalin, and studied the underlying mechanisms. "
08/15/2014 - "Bufotalin might be investigated as a novel anti-osteoblastoma agent. "
08/15/2014 - "In summary, our results suggest that ER stress contributes to bufotalin-induced apoptosis in osteoblastoma cells. "
08/15/2014 - "Finally, by using a mice xenograft model, we demonstrated that bufotalin inhibited U2OS osteoblastoma cell growth in vivo. "
08/15/2014 - "Our results showed that bufotalin induced osteoblastoma cell death and apoptosis in dose- and time-dependent manners. "