bixin

05/01/2017 - "Bixin ameliorates high fat diet-induced cardiac injury in mice through inflammation and oxidative stress suppression."
01/01/2021 - "Bixin acts as novel Nrf2 (NF-E2 p45-related factor 2) activator with the cytoprotection against oxidative stress and inflammation; this study mainly focused on the mechanism of Nrf2 activation by bixin and explored its potential feasibilities in long-term high-fat diet- (HFD-) caused hepatic steatosis and inflammatory response in vitro and in vivo. "
01/01/2023 - "Therapeutic potential of bixin on inflammation: a mini review."
01/01/2021 - "Bixin ameliorated CCl4-induced inflammation in kidneys by reducing the levels of TNF-α and IL-1β. "
01/01/2020 - "Furthermore, bixin inhibited inflammation and oxidative stress via activating nuclear factor erythroid 2-related factor 2 (NRF2), and its downstream genes in EAE mice, meanwhile, these effects were suppressed upon treatment with an NRF2 inhibitor, ML385. "

08/05/2020 - "Together, this study implies that bixin may protect against kidney interstitial fibrosis through stimulating Nrf2 activation in renal tubular cells."
08/05/2020 - "In vivo studies showed that administration of bixin induces Nrf2 signaling activation in tubular cells and markedly attenuates partial EMT of tubular cells and kidney interstitial fibrosis after subjecting to UUO. "
01/01/2020 - "The study demonstrated that bixin can be exploited therapeutically to alleviate renal interstitial fibrosis by targeting STAT6 signaling deactivation."
08/05/2020 - "The potential therapeutic strategy for bixin in alleviating kidney fibrosis remains largely unclear. "
01/01/2020 - "Corrigendum: Bixin Protects Against Kidney Interstitial Fibrosis Through Promoting STAT6 Degradation."

12/05/2012 - "These results indicate that bixin acts as a food-derived agonist of PPARα, and bixin treatment is useful for the management of obesity-induced metabolic dysfunctions in mice."
12/05/2012 - "Bixin activates PPARα and improves obesity-induced abnormalities of carbohydrate and lipid metabolism in mice."
12/05/2012 - "Moreover, bixin treatment also improved obesity-induced dysfunctions of carbohydrate metabolism, such as hyperglycemia, hyperinsulinemia, and hypoadiponectinemia. "

12/05/2012 - "Moreover, bixin treatment also improved obesity-induced dysfunctions of carbohydrate metabolism, such as hyperglycemia, hyperinsulinemia, and hypoadiponectinemia. "

12/05/2012 - "Moreover, bixin treatment also improved obesity-induced dysfunctions of carbohydrate metabolism, such as hyperglycemia, hyperinsulinemia, and hypoadiponectinemia. "