bietaserpine

08/01/1982 - "Significant reduction in surviving fraction was seen for doses of DL-152 as low as 5 mg/kg. Using KHT tumors growing as lung nodules, it was shown that toxicity of DL-152 was not apparent until 11 to 14 days after initiation of the tumor and that subsequent sensitivity of cells to DL-152 increased with increasing age of the lung tumor. "
08/01/1982 - "Hypoxic cells were detectable in 10-day-old lung tumors, a time at which the tumors were still resistant to the toxic effects of DL-152. "
08/01/1982 - "injection of diethylaminoreserpine (DL-152) to the tumor-bearing mouse. "
08/01/1982 - "Toxicity of diethylaminoreserpine to a transplantable tumor: the significance of the presence of hypoxic cells."
03/01/1982 - "Toxicity of diethylaminoreserpine to tumor cells: effects of drug alone and in combination with radiation."

04/01/1980 - "Diethylaminoreserpine (DL-152), an inhibitor of cyclic AMP phosphodiesterase, has been shown to kill clonogenic cells of the KHT fibrosarcoma when the drug is given intraperitoneally to the tumour-bearing mouse. "
01/01/1987 - "DL-152 was found to be toxic to cells of all the tumor models tested (KHT fibrosarcoma, RIF-1 fibrosarcoma, EMT-6 adenocarcinoma and Lewis lung carcinoma) when the drug was given by intraperitoneal injection to the tumor-bearing mouse and cell survival was measured by excision assay. "

01/01/1987 - "DL-152 was found to be toxic to cells of all the tumor models tested (KHT fibrosarcoma, RIF-1 fibrosarcoma, EMT-6 adenocarcinoma and Lewis lung carcinoma) when the drug was given by intraperitoneal injection to the tumor-bearing mouse and cell survival was measured by excision assay. "

05/20/1967 - "[Treatment of arterial hypertension with a new reserpine derivative: bietaserpine]."

01/01/1987 - "DL-152 was found to be toxic to cells of all the tumor models tested (KHT fibrosarcoma, RIF-1 fibrosarcoma, EMT-6 adenocarcinoma and Lewis lung carcinoma) when the drug was given by intraperitoneal injection to the tumor-bearing mouse and cell survival was measured by excision assay. "