|1.||Wang, Yi-Mei: 4 articles (12/2011 - 09/2007)|
|2.||Peng, Shuang-Qing: 4 articles (12/2011 - 09/2007)|
|3.||Yan, Chang-Hui: 2 articles (12/2011 - 09/2007)|
|4.||Wang, Hui-Jiao: 2 articles (10/2009 - 12/2008)|
|5.||Paixão, Natasha: 1 article (08/2015)|
|6.||Villar, José A F P: 1 article (08/2015)|
|7.||Wang, Tao: 1 article (08/2015)|
|8.||Comar, Moacyr: 1 article (08/2015)|
|9.||Silva, Luciana M: 1 article (08/2015)|
|10.||Neves, Luiza D R: 1 article (08/2015)|
|1.||Body Weight (Weight, Body)
09/01/2010 - "Within 30min of micro-infusion, 2-B4O initiated a significant reduction of body weight that lasted up to 24h following treatment. "
09/01/2010 - "2-B4O (50, 75mg/kg, ip) was injected in rat pups on post-natal days (0-2, 4-6 and 12-14) and the mean difference in body weight at 0.5, 1.2 and 24h following treatment was recorded. "
|2.||Wounds and Injuries (Trauma)
12/01/2008 - "In conclusion, the present study clearly indicated that butenolide could induce significant myocardial oxidative injuries. "
09/01/2007 - "Consistent with the in vitro findings, distinct myocardial toxicity in vivo was observed after administration of rats by gavage with butenolide (10 and 20 mg/kg/day) for 2 months, and the myocardial injuries were characterized by focal necrosis of myocardium and fragmentation of myofiber. "
10/01/2009 - "A single in ovo injection of butenolide resulted in significant oxidative injuries in embryonic livers and kidneys, as manifested by a dose-dependent depletion of sulfhydryl groups, reduction of glutathione peroxidase activity, and increase of thiobarbituric acid reactive substances production, an indicator of lipid peroxidation. "
12/01/2008 - "A single in ovo injection of butenolide to chick embryos, an excellent in vitro toxicology model resulted in significant oxidative injuries to the myocardium, manifested by a dose-dependent depletion of sulfhydryl groups, reduction of glutathione peroxidase (GPx) activity, and increase of thiobarbituric acid reactive substances production, a hallmark of lipid peroxidation. "
12/01/2008 - "In contrast, co-injections of butenolide to chick embryos with sodium selenite or vitamin C, two potent antioxidants, markedly abated these oxidative injuries. "
05/15/2011 - "Structure-activity relationship analysis showed that the introduction of dithiocarbamate side chains on the C-3 position of butenolide was crucial for anti-tumor activity."
10/25/2001 - "In addition, butenolide 28 efficiently decreased tumor formation induced by Moloney murine sarcoma virus (MSV) in NMRI mice while significantly increasing the survival time of MSV-infected mice."
04/01/1992 - "A butenolide compound (1E,3E,5E,7E)-5-hydroxy-4-(8-phenyl-1,3,5,7- octatetraenyl)-2(5H)-furanone (KNK-41), was shown to have strong anti-tumor activity. "
01/01/1997 - "A novel synthesized retinoidal butenolide, KYN-54, which suppresses large bowel as well as tongue carcinogenesis could be a useful agent for prevention of digestive organ cancers. "
08/01/2015 - "This paper describes the synthesis of 6 new digoxin derivatives substituted (on the C17-butenolide) with γ-benzylidene group and their cytotoxic effect on human fibroblast (WI-26 VA4) and cancer (HeLa and RKO) cell lines as well as their effect on Na,K-ATPase activity and expression. "
12/01/2011 - "Butenolide, a mycotoxin elaborated by several toxigenic Fusarium species, has been implicated as an etiological factor of Kashin-Beck disease and it is always detected in food from endemic Kashin-Beck disease areas. "
02/01/2009 - "Butenolide (BUT), a mycotoxin produced by Fusarium species, was detected often in corns or grains from endemic Kashin-Beck disease (KBD) areas in China. "
10/01/1995 - "Moreover, the concentration of 2-B4O, an endogenous sugar acid, is elevated in the circulation during starvation. "
11/01/1990 - "These findings suggest that 2-buten-4-olide is involved in the regulation of pituitary gonadotropin secretion directly by suppressing the pituitary responsiveness to GnRH, and that 2-buten-4-olide may play an important role in starvation-induced anestrus."
|1.||Thiobarbituric Acid Reactive Substances
|3.||Caspase 3 (Caspase-3)
|4.||Collagen Type II (Type II Collagen)
|5.||Sodium Selenite (Selenite)
|6.||Gonadotropin-Releasing Hormone (GnRH)