pamoic acid

RN given refers to parent cpd; structure

Also Known As:

4,4'-methylenebis(3-hydroxy)-2-naphthoic acid naphthalenecarboxylic acid; embonic acid; pamoic acid, dicesium salt; pamoic acid, dilithium salt; pamoic acid, dipotassium salt; pamoic acid, dirubidium salt; pamoic acid, disodium salt; sodium pamoate

Networked: 11 relevant articles (2 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Ni, Yicheng: 4 articles (08/2013 - 03/2007)
2.	Prinsen, Kristof: 4 articles (08/2013 - 11/2007)
3.	Mortelmans, Luc: 3 articles (07/2010 - 11/2007)
4.	Verbruggen, Alfons: 3 articles (07/2010 - 11/2007)
5.	Li, Junjie: 2 articles (08/2013 - 07/2010)
6.	Vanbilloen, Hubert: 2 articles (08/2013 - 07/2010)
7.	Bormans, Guy: 2 articles (07/2010 - 11/2007)
8.	Abir, Ariful Haque: 1 article (10/2020)
9.	Alam, Mahabub: 1 article (10/2020)
10.	Banik, Jewel: 1 article (10/2020)

Related Diseases

1.	Necrosis 08/01/2013 - "Pamoic acid derivatives have previously been reported to show a selective uptake in tissue undergoing cellular death via necrosis. " 07/15/2010 - "Development and evaluation of a 68Ga labeled pamoic acid derivative for in vivo visualization of necrosis using positron emission tomography." 11/01/2007 - "Necrosis avidity of (99m)Tc(CO)3-labeled pamoic acid derivatives: synthesis and preliminary biological evaluation in animal models of necrosis." 06/01/2009 - "Other necrosis avid probes like (123)I labeled hypericin and its monocarboxylic acid derivative and (99m)Tc(CO)(3)-bis-hydrazide-bis-DTPA pamoic acid need further evaluation but show already promising results for imaging of necrosis. " 03/01/2007 - "To compare a necrosis-avid contrast agent (NACA) bis-Gd-DTPA-pamoic acid derivative (ECIII-60) after intracoronary delivery with an extracellular agent Gd-DTPA after intravenous injection on magnetic resonance imaging (MRI) in a swine model of acute reperfused myocardial infarction (MI). "
2.	Infarction (Infarctions) 10/01/2020 - "Pharmacological inhibition of GPR35 reveals that pamoic acid reduces infarcts size in a GPR35 dependent manner. " 11/01/2007 - "In a search for an infarct avid tracer agent with improved properties, we have observed that bis-DTPA derivatives of pamoic acid have a high avidity for necrotic tissue. "
3.	Wounds and Injuries (Trauma) 01/01/2015 - "Stimulation of GPR35, with either the human-selective agonist pamoic acid or the reference agonist zaprinast, promoted VSMC migration in the scratch-wound assay. " 09/01/2017 - "GPR35 agonists (YE120, zaprinast, and pamoic acid) promoted wound repair in a concentration-dependent manner independently of cell proliferation, whereas a specific GPR35 antagonist CID2745687, forskolin, and pertussis toxin reversed the YE120-induced effect. "
4.	Stroke (Strokes) 10/01/2020 - "Here we show in a mouse model of stroke that GPR35 activation by pamoic acid is neuroprotective. "
5.	Pruritus (Itching) 12/01/2023 - "Our findings suggest that pamoic acid activation of peripheral GPR35 can contribute to the improvement of pruritus and its associated diseases." 12/01/2023 - "Pamoic acid-induced peripheral GPR35 activation improves pruritus and dermatitis."

Related Drugs and Biologics

1.	Pentetic Acid (DTPA)
2.	Acids
3.	hypericin
4.	Radioisotopes (Radionuclides)
5.	Hydrazines
6.	Gallium-68
7.	zaprinast
8.	Pertussis Toxin
9.	Gadolinium DTPA (Magnevist)
10.	Integrins

Related Therapies and Procedures

1.	Intravenous Injections
2.	Injections