|1.||Yang, Jai-Sing: 6 articles (08/2012 - 11/2009)|
|2.||Chung, Jing-Gung: 6 articles (08/2012 - 11/2009)|
|3.||Lu, Hsu-Feng: 4 articles (05/2011 - 11/2009)|
|4.||Chiang, Jo-Hua: 4 articles (05/2011 - 03/2010)|
|5.||Lu, Chi-Cheng: 3 articles (05/2011 - 03/2010)|
|6.||Huang, Hui-Ying: 2 articles (08/2012 - 01/2011)|
|7.||Liu, Chi-Ming: 2 articles (05/2011 - 07/2010)|
|8.||Lai, Tung-Yuan: 2 articles (07/2010 - 03/2010)|
|9.||Wang, Hai-Lung: 2 articles (07/2010 - 03/2010)|
|10.||Tang, Yih-Jing: 2 articles (07/2010 - 03/2010)|
08/01/2012 - "Taken together, danthron was demonstrated to be effective in killing C6 rat glioma cells via the ROS-promoted and mitochondria-dependent apoptotic pathways."
08/01/2012 - "This research focused on the induction of cytotoxic effects by danthron, a natural anthraquinone derivative on C6 rat glioma cells through exploring the means of cell death and the effects on mitochondrial function. "
08/01/2012 - "Danthron triggers ROS and mitochondria-mediated apoptotic death in C6 rat glioma cells through caspase cascades, apoptosis-inducing factor and endonuclease G multiple signaling."
|2.||Glioblastoma (Glioblastoma Multiforme)
07/01/2010 - "In this study, we investigated to examine whether or not danthron induced DNA damage and inhibited DNA repair gene expression in human brain glioblastoma multiforms (GBM 8401) cells. "
03/01/2010 - "The aim of this study is to investigate the mechanisms by danthron for the induction of apoptotic potential on human brain glioblastoma multiforms GBM 8401 cell line. "
11/01/2009 - "In this study, we investigated the effect of danthron on the cell migration and invasion of human brain glioblastoma multiforme GBM 8401 cells in vitro. "
07/01/2010 - "Danthron induces DNA damage and inhibits DNA repair gene expressions in GBM 8401 human brain glioblastoma multiforms cells."
03/01/2010 - "Danthron induced apoptosis through mitochondria- and caspase-3-dependent pathways in human brain glioblastoma multiforms GBM 8401 cells."
10/15/1990 - "This conclusion is in accordance with the hypothesis that the in vivo carcinogenic activity of danthron may be associated with tumor promotion."
10/15/1990 - "Because danthron, though carcinogenic, does not seem to be genotoxic, it and 8 other hydroxyanthraquinones were comparatively investigated for activities associated with tumor promotion, such as stimulation of cell proliferation and enhancement of malignant transformation. "
04/01/1989 - "The association of danthron and a rare bowel cancer in one case cannot prove a causative link. "
12/01/1988 - "Altogether 9 tumors were observed among animals given DMA with or without danthron. "
11/01/2009 - "Thus, danthron may be considered a therapeutic agent that can inhibit primary tumor growth and prevent metastasis."
12/31/1967 - "[The combination danthrone-acetophenolisatine in the treatment of functional constipation]."
11/01/1957 - "Use of doxinate with danthron as withdrawal therapy in the treatment of chronic functional constipation."
11/01/1971 - "[An interesting drug for the treatment of constipation: the association of calcium pantothenate and danthron]."
01/01/1966 - "[Clinical trial of a combination: calcium pantothenate-danthron in 28 cases of constipation of various etiologies]."
10/01/1959 - "Treatment of chronic functional constipation with dioctyl sodium sulfosuccinate and danthron."
|5.||Stomach Neoplasms (Stomach Cancer)
01/14/2011 - "Danthron, an anthraquinone derivative, induces DNA damage and caspase cascades-mediated apoptosis in SNU-1 human gastric cancer cells through mitochondrial permeability transition pores and Bax-triggered pathways."
01/14/2011 - "This study investigated the roles of caspase cascades, ROS, DNA damage, mitochondrial disruption, and Bax and Bcl-2 proteins in danthron-induced apoptosis of SNU-1 human gastric cancer cells, a commonly used cell culture system for in vitro studies. "
01/14/2011 - "Anthraquinones have been shown to induce apoptosis in different types of tumor cells, but the mechanisms of danthron-induced cytotoxicity and apoptosis in human gastric cancer cells have not been adequately explored. "
01/14/2011 - "In summary, it is suggested that danthron-induced apoptotic cell death was involved in mitochondrial depolarization, which led to release of cytochrome c, apoptosis-inducing factor (AIF), and endonuclease G (Endo G) and caused the activation of caspase-9 and -3 in SNU-1 human gastric cancer cells."
|2.||thiosuccinic acid (sulfosuccinate)
|5.||Proteins (Proteins, Gene)
|6.||DNA (Deoxyribonucleic Acid)
|9.||Apoptosis Inducing Factor
|10.||Messenger RNA (mRNA)