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glycylsarcosine

Also Known As:

Gly-Sar

Networked: 19 relevant articles (1 outcomes, 2 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Peptides: 82426
  - Oligopeptides: 519
    - Dipeptides: 945
      - glycylsarcosine: 19

Experts

1.	Smith, David E: 3 articles (04/2006 - 07/2004)
2.	Hu, Yongjun: 2 articles (04/2006 - 10/2005)
3.	Keep, Richard F: 2 articles (04/2006 - 10/2005)
4.	Inui, K: 2 articles (03/2000 - 01/2000)
5.	Saito, H: 2 articles (03/2000 - 01/2000)
6.	Terada, T: 2 articles (03/2000 - 01/2000)
7.	Akazawa, Takanori: 1 article (11/2018)
8.	Kanazu, Takushi: 1 article (11/2018)
9.	Kawai, Makoto: 1 article (11/2018)
10.	Ohnishi, Shuichi: 1 article (11/2018)

Related Diseases

1.	Starvation 07/01/1992 - "The results obtained from isolated kidney perfusion studies are summarized as follows: 1) clearance was fastest for Gly-Gly-Sar and slowest for Gly-Sar-Sar, 2) urinary excretion of Gly-Sar-Sar exceeded that of Gly-Gly-Sar or Gly-Sar, 3) there was accumulation of products of hydrolysis of Gly-Gly-Sar in the perfusate but not of Gly-Sar or Gly-Sar-Sar, 4) isolated brush-border and basolateral membranes of renal tubular cells lacked hydrolytic activity against Gly-Sar and Gly-Sar-Sar but possessed hydrolytic activity against Gly-Gly-Sar, 5) an excess amount of Gly-Sar-Sar reduced the rate of clearance of Gly-Gly-Sar by approximately 40% and significantly increased urinary excretion of this peptide, 6) the nonfiltering kidney cleared Gly-Gly-Sar at a rate which was 50% of that of the filtering kidney but did not clear Gly-Sar, and 7) starvation for 96 h was without a significant effect on the renal clearance of either Gly-Sar or Gly-Sar-Sar but significantly reduced the renal clearance of Gly-Gly-Sar and the brush-border membrane hydrolase activity against this peptide. "
2.	Glioma (Gliomas) 04/03/2006 - "The aims of the current study were (1) to quantify the role of PEPT2 in the uptake of glycylsarcosine (GlySar) in cultured neonatal astrocytes and (2) to examine GlySar transport and PEPT2 expression in two glioma cell lines. " 04/03/2006 - "Role of PEPT2 in glycylsarcosine transport in astrocyte and glioma cultures."
3.	Carcinoma (Carcinomatosis) 08/01/2009 - "Uptake by Caco-2 cells (human carcinoma cell line) and HeLa cells transfected with peptide transporter 1 (HeLa/PEPT1) was time- and temperature-dependent and was inhibited by typical PEPT1 inhibitors such as glycyl-sarcosine (Gly-Sar). " 04/01/1994 - "The characteristics of the transport of the dipeptide glycylsarcosine were studied in the human colon carcinoma cell line Caco-2 grown as a monolayer on impermeable plastic support. " 04/01/2006 - "Uptake of the PepT1 substrate glycylsarcosine [(3)H]-Gly-Sar was studied in vitro in the human colon carcinoma cell line Caco2/bbe monolayers as well as in vivo in mice injected with cytokines. "
4.	Neoplasms (Cancer) 09/15/1997 - "To explore the feasibility of targeting human tumor cells via their transport systems, dipeptide uptake was studied in the human fibrosarcoma cell line HT1080 and the human fibroblast cell line IMR-90 by the use of hydrolysis-resistant glycylsarcosine (Gly-Sar). " 11/01/1999 - "These are as follows: (1) oral delivery via H(+)/oligopeptide transporter, rat or human Pept1, in the intestine for beta-lactam antibiotics and a newly synthesized dipeptide, L-dopa-L-phenylalanine; (2) tumor cell specific delivery via the newly discovered H(+)/oligopeptide transporter(s) expressed in human fibrosarcoma cell line HT-1080 for model oligopeptides, glycylsarcosine and carnosine; (3) oral and hepatic delivery via an H(+)/monocarboxylate transporter in the intestine and an organic anion transporter in the liver for HMG-CoA reductase inhibitor, pravastatin; and (4) lung selective delivery via some type of transporter and avoidance of transfer into the brain via P-glycoprotein at the blood-brain barrier for a new quinolone antibacterial, HSR-903."
5.	Infections 01/01/1999 - "In addition, the basolateral-to-apical Gly-Sar transport was dependent on temperature, multiplicity of infection (MOI), and Gly-Sar concentration. " 09/01/1986 - "We measured the response of jejunal sodium (Na) absorption to neutral amino acid (L-alanine) and to dipeptides (L-alanyl-L-alanine, glycylsarcosine) in normal piglets and in piglets with acute viral diarrhea after experimental infection with transmissible gastroenteritis (TGE) virus. "

Related Drugs and Biologics

1.	Peptides (Polypeptides)
2.	Hydrolases
3.	glycyl-glycyl-sarcosine
4.	glycyl-sarcosyl-sarcosine
5.	glycylsarcosine
6.	Dipeptides
7.	Member 1 Subfamily B ATP Binding Cassette Transporter
8.	Peptide Transporter 1
9.	Cytochrome P-450 CYP3A
10.	Organic Anion Transporters