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perlapine
structure; RN given refers to parent cpd
Also Known As:
6-(4-methyl-1-piperazinyl)morphanthridine; 6-(4-methylpiperazin-1-yl)-11H-dibenzazepine; HUF-2333; PLP 100-127; perlapine monohydrochloride
Networked:
4
relevant articles (
1
outcomes,
1
trials/studies)
Relationship Network
Bio-Agent Context: Research Results
Heterocyclic Compounds: 198
Fused-Ring Heterocyclic Compounds
3-Ring Heterocyclic Compounds
Dibenzazepines: 4
perlapine: 4
Related Diseases
1.
Sleep Initiation and Maintenance Disorders (Insomnia)
04/01/1975 - "
The objectives of the study have been to evaluate the therapeutic efficacy of PLP 100-127 (6-(4-methyl-l-piperazinyl) morphanthridin) on patients with moderate to severe insomnia, to evaluate safety and tolerance of the drug and to investigate whether or not the drug may have dependence producing properties through the possible development of mental and/or physical dependence.
"
04/01/1975 - "
PLP 100-127 seems to have a favorable effect on moderate and severe insomnia in patients suffering from severe mental diseases.
"
2.
Parkinsonian Disorders (Parkinsonism)
03/01/1998 - "
As determined by the new dissociation constants, antipsychotic drugs which elicit Parkinsonism (trifluperazine, chlorpromazine, raclopride, haloperidol, fluphenazine, risperidone) bind more tightly than dopamine to D2, while those antipsychotic drugs which elicit little or no Parkinsonism (melperone, seroquel, perlapine, clozapine, remoxipride, molindone, sulpiride, olanzapine, sertindole) bind more loosely than dopamine to D2 receptors.
"
3.
Shock
01/01/1985 - "
Intermediate doses (0.3-1.0 mg/kg IM) of selected unsubstituted and 8-chlorine-substituted dibenzo-azepines (perlapine, 106-094, and clozapine) increased responding that was suppressed by electric shock, whereas selected 2-chlorine-substituted dibenzo-azepines (loxapine, clothiapine, and 105-056) did not consistently increase suppressed responding at any dose (0.001-0.1 mg/kg IM).
"
4.
Catalepsy
01/01/1975 - "
Haloperidol, perlapine and thioridazine induce catalepsy and enhance the turnover of DA in the striatum as indicated by the dose-dependent increase in the DA-metabolites, HVA and DOPAC.
"
Related Drugs and Biologics
1.
Haloperidol (Haldol)
2.
Clozapine (Clozaril)
3.
Raclopride
4.
Risperidone (Risperdal Consta)
5.
Remoxipride
6.
3,4-Dihydroxyphenylacetic Acid
7.
Trifluoperazine (Stelazine)
8.
Antipsychotic Agents (Antipsychotics)
9.
Thioridazine (Mellaril)
10.
Sulpiride (neogama)