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IOB 82
RN given refers to parent cpd
Also Known As:
IOB 82, sodium salt; IOB-82; NSC-146171; 3-(bis(2-chloroethyl)amino)-4-methylbenzoic acid
Networked:
2
relevant articles (
0
outcomes,
1
trials/studies)
Bio-Agent Context: Research Results
Organic Chemicals: 133
Hydrocarbons: 1713
Halogenated Hydrocarbons: 42
Mustard Compounds: 3
Nitrogen Mustard Compounds: 2
IOB 82: 2
Related Diseases
1.
Lymphatic Metastasis
01/01/1970 - "
A study of chromosomal behaviour in primary tumour cells and lymphatic metastases under the action of the cytostatic IOB 82.
"
2.
Polyploidy
07/01/1978 - "
IOB-82 treatment produced changes in chromosome numbers and especially the disappearance of polyploid cells and cell populations with 85-86 chromosomes.
"
3.
Chromosome Aberrations (Chromosome Abnormalities)
07/01/1978 - "
Twenty-four h after IOB-82 treatment (with small or large doses), the chromatid and chromosome aberrations (gaps, breaks, deletions, fragments) were also observed.
"
4.
Ascites
07/01/1978 - "
Changes produced and their incidence appear to depend on the concentration of IOB-82 employed and the morphological type of ascites cells.
"
07/01/1978 - "
Morphological and cytogenetical changes in HR-18 rat ascites cells after in vitro 3-[bis(2-chloroethyl)amino]-4-methylbenzoic acid (NSC-146171; IOB-82) administration.
"
07/01/1978 - "
A bifunctional alkylating agent, 3-[Bis(2-chloroethyl) amino]-4-methylbenzoic acid (NSC-146171; IOB-82) was administered in HR-18 rat ascites cell cultures (which presented 2 morphologic cellular types: A and B type cells, genetically, 2 cellular populations having 41-45 and 85-86 chromosomes and cells with high ploidy), and the morphological and cytogenetical effects were related to the compound concentration.
"
Related Drugs and Biologics
1.
Cytostatic Agents
2.
Alkylating Agents
3.
Acids