carboxyatractyloside

RN given refers to parent cpd; structure

Also Known As:

carboxyatractylate; dipotassium carboxyatractyloside; gummiferin; kaur-16-ene-18,19-dioic acid, 15-hydroxy-2-((2-o-(3-methyl-1-oxobutyl)-3,4-di-o-sulfo-beta-D-glucopyranosyl)oxy)-, dipotassium salt, (2beta,15alpha)-; potassium carboxyatractyloside

Networked: 14 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	De Grassi, Anna: 2 articles (12/2020 - 01/2016)
2.	Pierri, Ciro Leonardo: 2 articles (12/2020 - 01/2016)
3.	Castegna, Alessandra: 1 article (12/2020)
4.	Favia, Maria: 1 article (12/2020)
5.	Guerra, Lorenzo: 1 article (12/2020)
6.	Laera, Luna: 1 article (12/2020)
7.	Muscella, Antonella: 1 article (12/2020)
8.	Pesce, Vito: 1 article (12/2020)
9.	Trisolini, Lucia: 1 article (12/2020)
10.	Volpicella, Mariateresa: 1 article (12/2020)

Related Diseases

1.	Fatty Liver 01/01/2017 - "Protection against fatty liver is partially recapitulated by the systemic administration of low-dose carboxyatractyloside, a specific inhibitor of ANT. "
2.	Poisoning 06/01/2005 - "Carboxyatractyloside poisoning causes multiple organ dysfunction and can be fatal. " 06/01/2005 - "We describe nine cases of carboxyatractyloside poisoning in humans which, to our knowledge, has not previously been reported. " 06/01/2005 - "Carboxyatractyloside poisoning in humans." 01/15/2016 - "Albeit carboxyatractyloside (CATR) and bongkrekic acid (BKA) are known to be powerful and highly selective AAC inhibitors, able to induce mitochondrial dysfunction at molecular level and poisoning at physiological level, we estimated here for the first time their affinity for the human recombinant AAC2 by in vitro transport assays. "
3.	Necrosis 04/01/1998 - "Consumption of the plants containing Atr or carboxyatractyloside (carboxyAtr) has caused fatal renal proximal tubule necrosis and/or centrilobular hepatic necrosis in man and farm animals. " 05/01/1981 - "Marked hypoglycemia and elevated serum glutamic oxaloacetic transaminase and serum isocitric dehydrogenase concentrations occurred in pigs with acute hepatic necrosis that had received either cocklebur seedlings, ground bur or carboxyatractyloside."
4.	Hyperthyroidism 10/13/1997 - "'Hyperthyroidism' also resulted in doubling of the carboxyatractyloside-sensitive portion of the myristate-stimulated respiration. " 10/13/1997 - "The uncoupling effect of phytanic acid was less sensitive to carboxyatractyloside and was increased in the hyperthyroid state to a smaller extent than in the case of myristate. " 12/03/1991 - "The concentration of carboxyatractyloside necessary for maximal inhibition of respiration was 100 microM in hepatocytes from hypothyroid rats, but 200 microM and 300 microM in hepatocytes from euthyroid and hyperthyroid rats, respectively, indicating a possible correlation between levels of thyroid hormone and the amount or activity of adenine nucleotide translocase. "
5.	Hepatocellular Carcinoma (Hepatoma) 05/01/1991 - "In de-energized mitochondria from hepatoma (but not from mice liver), the concentration of adenine nucleotides in the matrix equilibrates with the medium concentration via a carboxyatractyloside (CATR)-insensitive transport system. " 06/25/1985 - "Moreover, in the fast-growing hepatoma 7777 the sensitivity of the adenine nucleotide translocase to inhibition by carboxyatractylate and bongkrekic acid was considerably decreased. "

Related Drugs and Biologics

1.	Bongkrekic Acid
2.	ATP Translocases Mitochondrial ADP
3.	Myristic Acid (Tetradecanoic Acid)
4.	Staurosporine
5.	Thyroid Hormones
6.	Phytanic Acid
7.	Pentobarbital (Nembutal)
8.	Oxidoreductases (Dehydrogenase)
9.	Digitonin
10.	Aspartate Aminotransferases (Aspartate Transaminase)