validamycins

RN given refers to cpd with unknown MF; structure given in Merck Index, 9th ed, #9570 has been revised in fifth source; structure in fifth source; see also record for validamycin A

Also Known As:

Networked: 4 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Chen, Moutong: 1 article (01/2022)
2.	Ding, Yu: 1 article (01/2022)
3.	Guo, JinYu: 1 article (01/2022)
4.	Li, Ying: 1 article (01/2022)
5.	Liang, TingTing: 1 article (01/2022)
6.	Liu, FangJie: 1 article (01/2022)
7.	Liu, Hui: 1 article (01/2022)
8.	Qiu, Bo: 1 article (01/2022)
9.	Wang, DaQuan: 1 article (01/2022)
10.	Wang, Juan: 1 article (01/2022)

Related Diseases

1.	Infections 10/22/2021 - "Infection studies with maize revealed that 1 and 2 exhibit more potent fungicidal activity than validamycin. "
2.	Carcinogenesis 01/01/2022 - "The KEGG pathways overrepresented in short-PFS group included fructose and mannose metabolism (p=0.028), streptomycin biosynthesis (p=0.028), acarbose and validamycin biosynthesis (p=0.013), ribosome biogenesis in eukaryotes (p=0.035), biosynthesis of vancomycin group antibiotics (p=0.004), apoptosis-fly (p=0.044), and tetracycline biosynthesis (p=0.044), while those overrepresented in long-PFS group included fatty acid biosynthesis (p=0.035), fatty acid metabolism (p=0.008), vancomycin resistance (p=0.008), longevity regulating pathway-worm (p=0.028), type II diabetes mellitus (p=0.004), and viral carcinogenesis (p=0.003). "
3.	Neuroblastoma 11/01/2015 - "The effects of validamycin pesticide ingredients on cell viability and of NP40 on the mRNA expression of 80 genes involved in nine key cellular pathways were examined in the human neuroblastoma SK-N-SH cell line. "
4.	Diabetes Mellitus 01/01/2022 - "The KEGG pathways overrepresented in short-PFS group included fructose and mannose metabolism (p=0.028), streptomycin biosynthesis (p=0.028), acarbose and validamycin biosynthesis (p=0.013), ribosome biogenesis in eukaryotes (p=0.035), biosynthesis of vancomycin group antibiotics (p=0.004), apoptosis-fly (p=0.044), and tetracycline biosynthesis (p=0.044), while those overrepresented in long-PFS group included fatty acid biosynthesis (p=0.035), fatty acid metabolism (p=0.008), vancomycin resistance (p=0.008), longevity regulating pathway-worm (p=0.028), type II diabetes mellitus (p=0.004), and viral carcinogenesis (p=0.003). "
5.	Congenital Abnormalities (Deformity) 01/01/2017 - "These results demonstrate that silencing of TRE gene expression can lead to wing deformities due to the down-regulation of the AP and TSH genes involved in wing development and that the TRE inhibitor validamycin can co-regulate chitin metabolism and the expression of wing development-related genes in wing bud tissue. "

Related Drugs and Biologics

1.	Acarbose
2.	Vancomycin
3.	Tetracycline (Achromycin)
4.	Streptomycin (Streptomycin Sulfate)
5.	Messenger RNA (mRNA)
6.	Pesticides
7.	Mannose (D-Mannose)
8.	Fructose
9.	Fatty Acids (Saturated Fatty Acids)
10.	Chitin