trimethylcolchicinic acid methyl ether

RN given refers to (S)-isomer; synonyms NSC-36354 & TMCA refers to tartrate [1:1]

Also Known As:

N-deacetylcolchiceine; NSC-36354; deacetylcolchicine; desacetylcolchicine; trimethylcolchicinic acid methyl ether tartrate (1:1), ((S)-(R-(R*,R*)))-isomer; trimethylcolchicinic acid methyl ether tartrate (2:1), ((S)-(R-(R*,R*)))-isomer; trimethylcolchicinic acid methyl ether tartrate, ((S)-(R-(R*,R*)))-isomer; (S)-7-amino-6,7-dihydro-1,2,3,10-tetramethoxybenzo(a)heptalen-9(5H)-one

Networked: 11 relevant articles (0 outcomes, 3 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Alkaloids: 5398
  - Colchicine: 5157
    - trimethylcolchicinic acid methyl ether: 11

Experts

1.	Erfani, Mostafa: 1 article (01/2017)
2.	Shafiei, Mohammad: 1 article (01/2017)
3.	Shirmardi, Seyed Pezhman: 1 article (01/2017)
4.	Jana, Sonali: 1 article (04/2011)
5.	Shekhawat, G S: 1 article (04/2011)
6.	Joshi, C S: 1 article (02/2010)
7.	Mathela, C S: 1 article (02/2010)
8.	Priya, E Sanmuga: 1 article (02/2010)

Related Diseases

1.	Neoplasms (Cancer) 02/23/1990 - "The method is linear over a concentration range of 1.0-200 ng/ml. The method has been shown to be a rapid, reliable method to monitor N-desacetylcolchicine levels in clinical trials in cancer patients." 02/01/1967 - "Clinical trial of trimethylcolchicinic acid methyl ether d-tartrate (TMCA; NSC-36354) in advanced cancer." 03/01/1963 - "Preliminary clinical experience with trimethylcolchicinic acid methyl ether d-tartrate (TMCA) in various malignancies." 01/01/2017 - "In this work, deacetylcolchicine a colchicine analogue was labeled with 99mTc via tricine as a coligand and characterized for its tumor targeting properties. "
2.	Melanoma (Melanoma, Malignant) 04/01/1972 - "Further study of trimethylcolchicinic acid, methyl ether, d-tartrate (TMCA; NSC-36354) in patients with malignant melanoma."
3.	Body Weight (Weight, Body) 02/01/2010 - "The results clearly indicated that the colchicine is more effective as an anti-inflammatory agent compared with phenylbutazone, the standard drug used in the study, whereas the oral administration of 6 mg/kg body weight of 2- demethylcolchicine, 3-demethylcolchicine and N-formyl-N-deacetylcolchicine showed very poor activity (41.6, 40.4, and 41.1% activity respectively)."
4.	BCR-ABL Positive Chronic Myelogenous Leukemia (Chronic Myelogenous Leukemia) 01/01/1980 - "9 patients with chronic granulocytic leukemia were treated sequentially with busulfan, 6-mercaptopurine, and trimethylcolchicinic acid methyl ether d-tartrate (TMCA; NSC-36354). "
5.	Ulcer 04/01/2011 - "The plant is used to cure arthritis, gout, rheumatism, inflammation, ulcers, bleeding piles, skin diseases, leprosy, impotency, snakebites, etc. Various compounds have been isolated from the plant parts mainly tubers and seeds, viz colchicine, colchicoside (its semi-synthetic derivative - thiocolchicoside), superbine, gloriosine, lumicolchicine, 3-demethyl-N-deformyl-N-deacetylcolchicine, 3-demethylcolchicine, N-formyl deacetylcolchicine. "

Related Drugs and Biologics

1.	tartaric acid (tartrate)
2.	Colchicine
3.	Phenylbutazone (Butazolidin)
4.	Anti-Inflammatory Agents (Anti-Inflammatories)
5.	Mercaptopurine (6 Mercaptopurine)
6.	Hydrocortisone (Cortisol)
7.	Glutathione (Reduced Glutathione)
8.	Busulfan (Busulfex)
9.	Adrenocorticotropic Hormone (ACTH)
10.	tricine

Related Therapies and Procedures

1.	Oral Administration