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tomatidine

RN given refers to (3beta,5alpha,22beta,25S)-isomer; structure
Also Known As:
5 alpha,20 beta(F),22 alpha(F),25 beta(F),27- azaspirostan-3 beta-ol; tomatidine, (3beta,5alpha,22alpha,25R)-isomer; (3 beta,5 alpha,22 beta, 25S)-spirosolan-3-ol
Networked: 44 relevant articles (8 outcomes, 11 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Yu, Tao: 3 articles (01/2022 - 01/2020)
2. Smit, Jolanda M: 3 articles (11/2021 - 01/2019)
3. van de Pol, Denise: 3 articles (11/2021 - 01/2019)
4. Huang, Wen-Chung: 3 articles (01/2021 - 01/2017)
5. Liou, Chian-Jiun: 3 articles (01/2021 - 01/2017)
6. Adams, Christopher M: 3 articles (10/2015 - 05/2014)
7. Dyle, Michael C: 3 articles (10/2015 - 05/2014)
8. Ebert, Scott M: 3 articles (10/2015 - 05/2014)
9. Friedman, Mendel: 3 articles (04/2015 - 01/2003)
10. Chu, Xiangyu: 2 articles (01/2022 - 01/2020)

Related Diseases

1. Obesity
2. Neoplasms (Cancer)
3. Infections
4. Stomach Neoplasms (Stomach Cancer)
02/28/2022 - "We investigated the efficacy of tomatidine using human gastric cancer-derived 85As2 cells and its tumor-bearing mouse model and evaluated the effect of tomatidine-rich tomato leaf extract (TRTLE) obtained from tomato leaves. "
02/28/2022 - "This study demonstrates that tomatidine and TRTLE inhibit the tumor growth in vivo and the proliferation of human gastric cancer-derived 85As2 cells in vitro, which could be due to the downregulation of ISG expression."
02/28/2022 - "Tomatidine has been reported to inhibit the growth of cultured cancer cells in vitro, but its anti-cancer activity in vivo and inhibitory effect against gastric cancer cells remain unknown. "
02/28/2022 - "The Steroidal Alkaloid Tomatidine and Tomatidine-Rich Tomato Leaf Extract Suppress the Human Gastric Cancer-Derived 85As2 Cells In Vitro and In Vivo via Modulation of Interferon-Stimulated Genes."
04/18/2012 - "The inhibitory activities in terms of IC(50) values (concentration that inhibits 50% of the cells under the test conditions) of the parent compound and the hydrolysates, isolated by preparative HPLC, against normal human liver and lung cells and human breast, gastric, and prostate cancer cells indicate that (a) the removal of sugars significantly reduced the concentration-dependent cell-inhibiting effects of the test compounds, (b) PC3 prostate cancer cells were about 10 times more susceptible to inhibition by α-tomatine than the breast and gastric cancer cells or the normal cells, (c) the activity of α-tomatine against the prostate cancer cells was 200 times greater than that of the aglycone tomatidine, and (d) the activity increased as the number of sugars on the aglycone increased, but this was only statistically significant at p < 0.05 for the normal lung Hel299 cell line. "
5. Fatty Liver

Related Drugs and Biologics

1. solanidine
2. Apolipoproteins E (ApoE)
3. solasodine
4. Sirtuin 1
5. Collagen Type II (Type II Collagen)
6. Transferases
7. Cholesterol
8. Acyl Coenzyme A (Acyl CoA)
9. Tomatine
10. Alkaloids

Related Therapies and Procedures

1. Intraperitoneal Injections
2. Chemoprevention
3. Aftercare (After-Treatment)