tomatidine

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4 relevant articles (1 outcomes, 0 trials/studies) found for this Bio-Agent

Description: RN given refers to (3beta,5alpha,22beta,25S)-isomer; structure

Also Known As:

5 alpha,20 beta(F),22 alpha(F),25 beta(F),27- azaspirostan-3 beta-ol; tomatidine, (3beta,5alpha,22alpha,25R)-isomer; (3 beta,5 alpha,22 beta, 25S)-spirosolan-3-ol

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 23

Alkaloids: 633

Solanaceous Alkaloids: 3

Related Diseases

1.	Body Weight (Weight, Body) 01/01/2003 - "In non-pregnant mice, observed ratios of % liver weights to body weights (%LW/BWs) were significantly greater than those of the control values as follows (all values in % vs matched controls+/-S.D.): solanidine, 25.5+/-13.2; solasodine 16.8+/-12.0; and tomatidine, 6.0+/-7.1" 01/01/2003 - "For pregnant mice (a) body weight gains were less with the algycones than with controls: solanidine, -36.1+/-14.5; solasodine, -17.9+/-14.3; tomatidine, -11.9+/-18.1; (b) litter weights were less than controls: solanidine, -27.0+/-17.1; solasodine, -15.5+/-16.8; tomatidine, no difference; (c) the %LTW/BW ratio was less than that of the controls and was significant only for solasodine, -8.7+/-13.7; and (d) the average weight of the fetuses was less than the controls: solanidine, -11.2+/-15.2; solasodine, -11.4+/-9.4; tomatidine, no difference" Get all the results and reference details, order at left...
2.	Neoplasms (Cancer) 07/09/2008 - "Here, we demonstrate that tomatidine acts as an anti-inflammatory agent by blocking NF-kappaB and JNK signaling, and may possibly be developed as a useful agent for the chemoprevention of cancer or inflammatory diseases." 03/01/2001 - "Here we examined the ability of steroidal alkaloids of plant origin, namely the Veratrum sp. alkaloid cyclopamine and the Lycopersicon sp. alkaloid tomatidine, to act as potent and effective chemosensitizers in multidrug resistant tumor cells" Get all the results and reference details, order at left...
3.	Inflammation 07/09/2008 - "We use the LPS-stimulated macrophage as a model of inflammation to investigate the anti-inflammatory effects of tomatidine and solasodine, whose structures resemble glucocorticoids" Get all the results and reference details, order at left...
4.	Hepatomegaly 01/01/2003 - "The aglycone forms of three steroidal glycoalkaloids-solanidine (derived by hydrolytic removal of the carbohydrate side chain from the potato glycoalkaloids alpha-chaconine and alpha-solanine), solasodine (derived from solasonine in eggplants) and tomatidine (derived from alpha-tomatine in tomatoes)-were evaluated for their effects on liver weight increase (hepatomegaly) in non-pregnant and pregnant mice and on fecundity in pregnant mice fed for 14 days on a diet containing 2.4 mmol/kg of aglycone" Get all the results and reference details, order at left...
5.	Hemolysis 04/01/1992 - "Hemolytic activities of 3 steroid saponins reached plateaus within 5 min, whereas those of 4 triterpenoid saponins did not within 60 min. Erythrocytes pretreated with a low concentration of tigogenin were resistant to hemolysis of some of these saponins, but those pretreated with hecogenin or tomatidine were as sensitive as non-treated erythrocytes" Get all the results and reference details, order at left...
5 Diseases and 4 more articles analyzed in the Research Interface, order at left...

Related Drugs and Biologics

1.	solasodine
2.	solanidine
3.	NF-kappa B (NF-kB)
4.	Saponins
5.	Glucocorticoids
6.	Alkaloids
7.	alpha-solanine
8.	alpha-tomatine
9.	sarsasapogenin
10.	alpha-solamargine
13 Drugs and Important Bio-Agents and 4 more articles analyzed in the Research Interface, order at left...

Related Therapies and Procedures

1.	Chemoprevention
1 Therapies and Procedures and 1 more articles analyzed in the Research Interface, order at left...

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