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tiglylglycine

RN is from 9th CI

Networked: 13 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Amino Acids: 30675
  - Glycine: 5151
    - tiglylglycine: 13

Experts

1.	Kestenbaum, Bryan: 3 articles (01/2022 - 01/2020)
2.	Zelnick, Leila R: 3 articles (01/2022 - 01/2020)
3.	Hoofnagle, Andrew N: 3 articles (01/2021 - 01/2020)
4.	Seliger, Stephen: 2 articles (01/2022 - 01/2020)
5.	Himmelfarb, Jonathan: 2 articles (01/2021 - 11/2020)
6.	Chen, Yan: 2 articles (11/2020 - 01/2020)
7.	Wang, Ke: 2 articles (11/2020 - 01/2020)
8.	Bansal, Nisha: 1 article (01/2022)
9.	CRIC Study Investigators: 1 article (01/2022)
10.	Chen, Jing: 1 article (01/2022)

Related Diseases

1.	Ketosis 01/01/2018 - "The second patient presented at 6 months of age with ketoacidosis, and was found to have elevations of urinary 2-methyl-3-hydroxybutyric acid, 2-methylacetoacetic acid, and tiglylglycine. " 12/01/2008 - "Organic aciduria typical of this rare inborn error metabolism was found when the elder sibling presented with an episode of severe ketoacidosis at 20 months of age, which consisted of excessive excretion of ketones, tiglylglycine, 2-methyl-3-hydroxybutyrate, and 2-methylacetoacetate. " 01/01/2005 - "Biochemically, beta-ketothiolase deficiency is characterized by intermittent ketoacidosis and urinary excretion of 2-methyl-acetoacetate (MAA), 2-methyl-3-hydroxybutyrate (MHB) and tiglylglycine (TG), whereas in MHBD deficiency only MHB and tiglylglycine accumulate. " 01/01/2018 - "Bio chemical tests that suggested diagnose of beta ketothiolase deficiency were attacks of ketoacidosis with urinary exertion of 2-methyl-3-hydroxybutyric acid 2-methyl aceto acetic acid tiglylglycine. "
2.	Propionic Acidemia 11/01/1972 - "Excretion of tiglylglycine in propionic acidemia." 04/01/1991 - "1H-NMR spectra of urine from a patient with propionic acidemia show peaks of 3-hydroxy-n-valerate, methylcitrate, propionyl glycine, 3-hydroxy-n-butyrate, lactate, 3-hydroxypropionate, tiglylglycine and hippurate. "
3.	Cognitive Dysfunction 01/01/2022 - "Lower kidney clearances of five of the eight secretory solutes (cinnamoylglycine, isovalerylglycine, kynurenic acid, pyridoxic acid, and tiglylglycine) were associated with cognitive decline after adjustment for baseline eGFR, proteinuria, and other confounding variables. "
4.	Mitochondrial Diseases (Mitochondrial Disease) 02/01/2017 - "The female, who was suspected of having a seizure disorder but not autism, did not have elevated phenolic compounds but did have a significantly elevated value of the metabolite tiglylglycine, a marker for mitochondrial dysfunction and/or mutations. " 02/01/2017 - "All 3 had elevated urinary glyphosate, and all of the triplets and their mother had elevated values of succinic acid or tiglylglycine, which are indicators of mitochondrial dysfunction. "
5.	Autosomal Dominant Polycystic Kidney (ADPKD) 01/01/2020 - "After adjusting for demographics, clinical characteristics, and kidney function measures, the fractional excretions of three secretory solutes were lower in patients with ADPKD and preserved GFR compared with healthy individuals: 52% lower cinnamoylglycine excretion (95% confidence interval, 24% to 70%), 53% lower tiglylglycine excretion (95% confidence interval, 23% to 71%), and 91% lower xanthosine excretion (95% confidence interval, 83% to 95%). " 01/01/2020 - "In addition to lower excretions of tiglylglycine and xanthosine, patients with ADPKD and reduced GFR also demonstrated 37% lower dimethyluric acid excretion (95% confidence interval, 21% to 50%), 58% lower hippurate excretion (95% confidence interval, 48% to 66%), 48% lower isovalerylglycine excretion (95% confidence interval, 37% to 56%), and 31% lower pyridoxic acid excretion (95% confidence interval, 16% to 42%) compared with patients with non-ADPKD CKD and comparable eGFR. "

Related Drugs and Biologics

1.	2-methyl-3-hydroxybutyric acid
2.	Acids
3.	Pyridoxic Acid
4.	Kynurenic Acid (Kynurenate)
5.	Beta ketothiolase deficiency
6.	cinnamoylglycine
7.	hippuric acid
8.	Succinic Acid (Succinate)
9.	Lactic Acid (Lactate)
10.	Acetic Acid (Vinegar)