oxantel

oxyphenyl analog of pyrantel; RN given refers to (E)-isomer; synonym CP-14,445-16 refers to oxantel pamoate

Also Known As:

1,4,5,6-tetrahydro-2-(3-hydroxy styryl)-1-methylpyrimidine; CP 14,445; CP-14,445; oxantel monohydrochloride, (E)-isomer; oxantel tartrate; oxantel tartrate (1:1), (R-(R*,R*))-isomer

Networked: 24 relevant articles (11 outcomes, 6 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Charvet, Claude L: 1 article (07/2021)
2.	Grencis, Richard K: 1 article (07/2021)
3.	Hansen, Tina V A: 1 article (07/2021)
4.	Issouf, Mohamed: 1 article (07/2021)
5.	Neveu, Cédric: 1 article (07/2021)
6.	Catmull, Deanne: 1 article (01/2014)
7.	D'Cruze, Tanya: 1 article (01/2014)
8.	Dashper, Stuart: 1 article (01/2014)
9.	Hoffmann, Brigitte: 1 article (01/2014)
10.	Liu, Sze Wei: 1 article (01/2014)

Related Diseases

1.	Trichuriasis 01/01/1978 - "For trichuriasis, oxantel-pyrantel given twice, 12 hours apart, appears to be the best treatment schedule and further clinical trials using this regimen are suggested." 07/20/2021 - "Control of human trichuriasis is a particular challenge, as most anthelmintics have a limited single-dose efficacy, with the striking exception of the narrow-spectrum anthelmintic, oxantel. " 11/01/2002 - "Both drugs had a moderate efficacy against Trichuris trichiura infection, but pyrantel-oxantel had a higher cure rate (31.5% vs. 23.3%, P < 0.01), though the reductions in egg counts did not differ significantly and were more than 80%. " 07/01/1976 - "It is concluded that oxantel is a safe and effective anthelmintic for severe clinical trichuriasis." 04/01/1982 - "[Massive trichocephaliasis and other helminthiasis in children and its treatment with pyrantel pamoate/oxantel]."
2.	Infections 06/01/1976 - "Clinical Trial Of Oxantel Pamoate(Cp-14, 445) On Trichocephalus Trichiurus Infection." 01/01/1978 - "Oxantel, the most recent drug shown to be effective against Trichuris is discussed, as is oxantel-pyrantel which promises to be effective against mixed helminthic infections." 12/01/1979 - "[Treatment of mixed helminthic infection with oxantel-pyrantel pamoate (author's transl)]." 06/01/1979 - "A clinical trial of oxantel and pyrantel against intestinal nematodes infections." 12/01/1975 - "These findings show a single dose of oxantel and pyrantel pamoate mixture to be a highly effective and acceptable treatment for multiple infections with these nematodes."
3.	Nematode Infections 01/01/1978 - "The combination, oxantel-pyrantel is a safe and effective treatment for multiple intestinal nematode infection." 11/01/2002 - "Evaluation of the efficacy of pyrantel-oxantel for the treatment of soil-transmitted nematode infections." 09/01/1980 - "Intestinal nematode infections and efficacy study of oxantel-pyrantel pamoate among plantation workers." 01/01/1978 - "Anthelminthic effect of oxantel and oxantel-pyrantel in intestinal nematode infections." 11/01/2002 - "A randomized controlled trial comparing the efficacy of pyrantel-oxantel (10 mg/kg) with mebendazole (500 mg) was performed on 1329 schoolchildren aged 6-9 years on Pemba Island in September-October 2000 to evaluate alternative single-dose drugs for regular treatment of intestinal nematode infections. "
4.	Ascariasis 01/01/1978 - "The best results were obtained using oxantel, either alone or in combination with pyrantel, at 15 to 20mg/kg. Only 2 of 152 patients with ascariasis were not cured after a single dose of pyrantel (given as oxantel-pyrantel) of 10, 15 or 20mg/kg, and both these patients were from the group given the lowest dose. " 01/01/1978 - "In a pilot study in 17 children, oxantel-pyrantel as one single dose of 10 to 20mg/kg of each, gave good results in ascariasis but poor cure rates in both trichuriasis and necatoriasis. " 01/01/1978 - "204 individuals from a rural community were given a single dose of oxantel-pyrantel at 15mg/kg bodyweight and if still infected, 20mg/kg bodyweight, with cure rates of 100%, 53% and 71% for ascariasis, trichuriasis and hookworm infection, respectively. " 12/01/1977 - "The results of the trial were summarized as follows: 1. The cure rates (egg negative conversion rates) and egg reduction rates for oxantel/pyrantel tablets were 85.3% and 97% in trichuriasis, 100% each in ascariasis and ancylostomiasis. " 01/01/1978 - "32 elementary school children were treated for multiple intestinal helminthiasis (ascariasis, trichuriasis and hookworm infections) with a combination of the pamoate salts of oxantel and pyrantel in a dose of 15 to 20mg/kg body weight of each in 1 daily dose for 3 consecutive days. "
5.	Coinfection 01/01/1978 - "The results of the present study suggest that oxantel-pyrantel is more effective in the treatment of mixed infections of Ascaris and Trichuris, and was more acceptable to the patients, than mebendazole." 01/01/1978 - "A comparative study of the effect of oxantel-pyrantel suspension and mebendazole in mixed infections with Ascaris and Trichuris." 12/01/1977 - "A total of 34 subjects with the mixed infections were treated with oxantel/pyrantel tablets (100 mg/tablet each) in a single dose of 15 mg/kg body weight, and another group of 22 Trichuris infected cases received oxantel pamoate tablets (125 mg/tablet) in a single dose of 15 mg/kg. All stool examinations were done before the treatment and 3 weeks after the treatment. " 01/01/1978 - "A comparative trial was carried out in 4 orphanges in Seoul, to compare the anthelminthic efficacy of oxantel-pyrantel suspension and mebendazole tablets against mixed infections of Ascaris lumbricoides and Trichuris trichiura. "

Related Drugs and Biologics

1.	Pyrantel
2.	Anthelmintics
3.	Tablets
4.	Mebendazole (Anti-Worm)
5.	quantrel
6.	Immunoglobulin E (IgE)
7.	Suspensions
8.	Pyrantel Pamoate (Pyrantel Embonate)
9.	Drinking Water
10.	Clavulanic Acid (Potassium Clavulanate)