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stercuronium

analog of conessine; RN given refers to iodide

Also Known As:

N-ethyl-N-(cona-4,6-diene-3 beta-yl)dimethylammonium iodide; stercuronium bromide

Networked: 2 relevant articles (1 outcomes, 0 trials/studies)

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Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Alkaloids: 5398
  - stercuronium: 2

Related Diseases

1.	Bradycardia 10/01/1980 - "1 The antimuscarinic activity of stercuronium, a competitive neuromuscular blocking drug, has been compared in the anaesthetized guinea-pig, guinea-pig atria, bladder and ileum, rabbit atria and the sympathetically innervated rabbit ear artery preparation using carbachol (CCh) as agonist.2 In the anaesthetized guinea-pig, stercuronium (0.2 and 2.0 mumol/kg) produced significantly greater inhibition (P < 0.05) of the bradycardia than of the vasodepressor response produced by CCh, the difference being 2 fold at the low dose and 5.8 fold at the higher dose.3 In guinea-pig atria the negative chronotropic response to CCh was inhibited to a similar degree to the negative inotropic response by stercuronium, whereas in bladder and ileum stercuronium was 17 fold less active as an antimuscarinic drug.4 The affinity of stercuronium for the prejunctional muscarinic receptor on sympathetic nerve endings in the rabbit ear artery was similar to that for the muscarinic receptor mediating negative inotropic responses to CCh in the rabbit left atrium, and 2.3 fold less than the affinity for the muscarinic receptors in guinea-pig atria.5 A similar trend was observed with gallamine, another neuromuscular blocking drug, when results obtained in the rabbit ear artery preparation were compared to previously reported data. "
2.	Ganglion Cysts (Ganglion) 01/01/1980 - "pA2 values estimated from Schild plots indicated significantly higher affinities of stercuronium (x100) and pirenzepine (x23) and a significantly lower affinity of 4-diphenylacetoxy-N-methylpiperidine methiodide (x0.39) for the ganglion than for the ileum. "

Related Drugs and Biologics

1.	Muscarinic Antagonists
2.	Muscarinic Receptors (Muscarinic Acetylcholine Receptor)
3.	Gallamine Triethiodide (Gallamine)
4.	Carbachol (Carbastat)
5.	Pirenzepine
6.	4- diphenylacetoxy- 1,1- dimethylpiperidinium