reticuline

opium alkaloid; dopamine receptor blocker; RN given refers to (S)-isomer; structure

Also Known As:

reticuline hydrochloride, (+,-)-isomer; reticuline perchlorate; reticuline, (+,-)-isomer; reticuline, (R)-isomer; reticuline, 14C-labeled, (+,-)-isomer

Networked: 15 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Alkaloids: 5398
  - Benzylisoquinolines: 151
    - reticuline: 15
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Isoquinolines: 34
      - Benzylisoquinolines: 151
        reticuline: 15

Experts

1.	Al-Amri, A M: 2 articles (05/2004 - 03/2004)
2.	El-Haj, B M: 2 articles (05/2004 - 03/2004)
3.	Juma'a, M H: 2 articles (05/2004 - 03/2004)
4.	Smith, R M: 2 articles (05/2004 - 03/2004)
5.	Bian, Bao-Lin: 1 article (12/2021)
6.	Cui, Meng-Yao: 1 article (12/2021)
7.	Gao, Wen-Ya: 1 article (12/2021)
8.	Ni, Li-Qi: 1 article (12/2021)
9.	Si, Nan: 1 article (12/2021)
10.	Wang, Hong-Jie: 1 article (12/2021)

Related Diseases

1.	Fibrosis (Cirrhosis) 01/01/1995 - "The following morphological peculiarities of bone marrow stromal tissue have been identified: abnormal localisation of immature hemopoietic cells, reticuline fibrosis, disorganized erythroid islands, and intranuclear virus-like pathologic inclusions in all stromal cells. " 01/01/1980 - "It was shown that diffuse reticuline fibrosis may develop in lymphosarcomas. " 01/01/1980 - "Examinations of stroma of lymph nodes (50 patients) in lympho- and reticulosarcomas revealed three types of alterations of the reticuline carcass: (1) diffuse destructive changes, (2) focal reticuline fibrosis against the background of destructive lesions, and (3) diffuse reticuline fibrosis. " 09/01/1994 - "The pathogenetic mechanism of the fibrosis of the bone marrow may be similar to sic sic of the MPD in which a stimulus to secrete reticuline or collagen derives from abnormal marrow megakaryocytes. "
2.	Neuroblastoma 06/25/2004 - "These three compounds were toxic to SH-SY5Y neuroblastoma cells and inhibited mitochondrial respiratory complex I. It is possible that uptake of the benzylisoquinoline derivatives reticuline and N-methylcoculaurine and their accumulation in the brain may be related to the pathogenesis of the local endemic disease." 09/28/2004 - "Feeding of [ring-(13)C(6)]-tyramine, [1-(13)C, N-(13)CH(3)]-(S)-reticuline and [N-CD(3)]-thebaine to the neuroblastoma cells led each to the position-specific labeling of morphine, as established by GC/MS/MS. Without doubt, human cells can produce the alkaloid morphine. " 09/28/2004 - "Benzylisoquinoline alkaloids present in human neuroblastoma cells (SH-SY5Y) and human pancreas carcinoma cells (DAN-G) were identified by GC/tandem MS (MS/MS) as norlaudanosoline (DAN-G), reticuline (DAN-G and SH-SY5Y), and morphine (10 nM, SH-SY5Y). "
3.	Opium Dependence 05/28/2004 - "The GC-MS detection and characterization of reticuline as a marker of opium use." 03/10/2004 - "The GC-MS detection and characterization of reticuline as a marker of opium use."
4.	Primary Myelofibrosis (Myelosclerosis) 01/01/1996 - "Reticuline myelofibrosis and reactive lymphoplasmacytosis were also present. "
5.	Ganglion Cysts (Ganglion) 05/01/2005 - "Ganglia incubated in vitro with reticuline or L-DOPA for 1 hour exhibited a concentration and time dependent statistically significant increase in their endogenous morphine levels (5.0 +/- 0.47, 3.6 +/- 0.45 ng/ganglion, respectively). "

Related Drugs and Biologics

1.	Benzylisoquinolines
2.	Morphine (MS Contin)
3.	Electron Transport Complex I (NADH-CoQ Reductase)
4.	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)
5.	Xylenes (Xylene)
6.	Tyramine
7.	Thebaine
8.	Tetrahydropapaveroline
9.	Levodopa (L Dopa)
10.	Hesperidin

Related Therapies and Procedures

1.	Injections