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pyridoxal phosphate gamma-glutamyl hydrazone

Also Known As:

PLPGH

Networked: 3 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyridines: 88
    - Picolines: 14
      - Vitamin B 6: 1882
        Pyridoxal: 372
        Pyridoxal Phosphate: 308
        pyridoxal phosphate gamma-glutamyl hydrazone: 3
Enzymes and Coenzymes: 1
- Coenzymes: 558
  - Pyridoxal Phosphate: 308
    - pyridoxal phosphate gamma-glutamyl hydrazone: 3

Experts

1.	Salazar, Patricia: 1 article (10/2015)
2.	Tapia, Ricardo: 1 article (10/2015)

Related Diseases

1.	Tonic-Clonic Epilepsy (Epilepsy, Tonic Clonic) 02/01/1994 - "In the present study we report that, surprisingly, immature rats from 2 to 20 days of age treated with PLPGH (80 mg/kg) showed generalized tonic-clonic convulsions, whereas no convulsions at all were present in 30 days-old or older rats. "
2.	Seizures (Absence Seizure) 03/01/1975 - "It is concluded that the increase in the susceptibility to seizures induced by PLPGH during development is probably related to the increase observed in the sensitivity of glutamate decarboxylase in vivo to a decrease of pyridoxal 5'-phosphate levels. " 03/01/1975 - "Seizures were induced by pyridoxal phosphate-gamma-glutamyl hydrazone (PLPGH), a drug previously reported to reduce the levels of pyridoxal 5'-phosphate and as a consequence to inhibit the activity of glutamate decarboxylase in brain of adult mice. "
3.	Epilepsy (Aura) 10/01/2015 - "Thiosemicarbazide (TSC) and γ-glutamyl-hydrazone (PLPGH) inhibit the free PLP-dependent isoform (GAD65) activity after systemic administration, leading to epilepsy in mice and in young, but not in adult rats. "

Related Drugs and Biologics

1.	pyridoxal phosphate gamma-glutamyl hydrazone
2.	Protein Isoforms (Isoforms)
3.	Pyridoxal
4.	Hydrazones
5.	Glutamate Decarboxylase (Decarboxylase, Glutamate)
6.	trans-sodium crocetinate (crocetin)
7.	thiosemicarbazide