|1.||Quintel, Michael: 4 articles (06/2010 - 08/2003)|
|2.||Woods, C M: 4 articles (11/2001 - 05/2000)|
|3.||Lanza, Gregory M: 3 articles (08/2015 - 06/2006)|
|4.||Wickline, Samuel A: 3 articles (08/2015 - 06/2006)|
|5.||Valette, Julien: 3 articles (05/2014 - 08/2012)|
|6.||Arnold, John H: 3 articles (08/2010 - 09/2003)|
|7.||Hirschl, Ronald B: 3 articles (09/2005 - 03/2002)|
|8.||Flemmer, Andreas W: 2 articles (11/2014 - 01/2005)|
|9.||Fattal, Elias: 2 articles (05/2014 - 08/2012)|
|10.||Tsapis, Nicolas: 2 articles (05/2014 - 08/2012)|
01/01/1994 - "We have shown using a Vx2 rabbit model that 3 and 5ml/kg of perflubron emulsion were highly effective in imaging liver tumors. "
01/01/2014 - "Owing to the encapsulated liquid PFOB and strong near-infrared (NIR) absorption of PPy shell, the resulted PPy capsules showed great promise in ultrasound imaging guided photothermal ablation of tumor cells without inducing any significant side effect. "
01/01/1992 - "HBO alone produced only a small improvement in the radiation response of BA1112 tumors in WAG/rij rats, while regimens combining HBO with Oxygent produced much greater radiation sensitization. "
01/01/1994 - "Efficacy of Imagent BP at 1.5ml/kg in a rabbit liver tumor model."
08/01/2015 - "In vivo imaging of angiogenesis-targeted PFOB nanoparticles was demonstrated in a rabbit model of cancer on a clinical 3 Tesla scanner. "
|2.||Respiratory Insufficiency (Respiratory Failure)
02/07/1996 - "Perflubron may be safely administered into the lungs of patients with severe respiratory failure receiving extracorporeal life support and may be associated with improvement in gas exchange and pulmonary compliance."
09/01/1998 - "In animal models of several types of hypoxic respiratory failure, perflubron's efficacy in improving gas exchange and compliance has been demonstrated. "
07/01/1996 - "Partial liquid ventilation with perflubron provides effective improvement in gas exchange in an adult animal model of respiratory failure."
07/01/1999 - "Partial Liquid Ventilation (PLV), a treatment for acute respiratory failure in which the lungs are filled, either partially or to functional residual capacity (FRC), with perfluorochemical (PFC) liquid while the patient is on mechanical gas ventilation, has progressed to clinical trials using the PFC perflubron (PFB). "
02/01/2001 - "Eighteen adult patients (mean +/- SEM age, 37.9 +/- 3.4 years) with severe respiratory failure, some of whom required extracorporeal life support (72%), and who were managed with partial liquid ventilation with perflubron. "
|3.||Acute Lung Injury
02/01/1997 - "The combination of low-dose perflubron with high-frequency oscillatory ventilation leads to more rapid improvement in arterial oxygenation than high-frequency oscillatory ventilation alone, in a piglet model of acute lung injury. "
01/01/1994 - "Effect of continuous rotation on the efficacy of partial liquid (perflubron) breathing in canine acute lung injury."
11/01/2005 - "LBFO-PLV is a viable mode of ventilation in a model of acute lung injury and is associated with significant preservation of perflubron in comparison with high-frequency oscillatory ventilation-PLV. "
04/01/2001 - "Our data suggest that the optimal dose of perflubron to achieve the lowest oxygenation index during HFO-PLV is between 5 and 15 mL/kg. The combination of HFOV and perflubron administration is a novel strategy in the treatment of acute lung injury that shows some promise and merits additional investigation. "
03/01/2001 - "Partial liquid ventilation with the perfluorochemical, perflubron, has been shown to improve lung mechanics and enhance gas exchange in the treatment of severe acute lung injury. "
02/01/1995 - "The continued improvement in the BAEP in the Oxygent-treated group compared with the control groups suggests that Oxygent may be of some value as a protective agent to the brain stem during ischemia. "
01/01/1995 - "Following 30 minutes of ischemia and 30 minutes of reperfusion with KH solution, hearts subjected to the 100% PFOB emulsion showed improved recovery of left ventricular function. "
04/01/2002 - "This study suggests that the administration of perflubron emulsion prevents gastrointestinal tract ischemia in cardiac surgical patients and may preserve postoperative gastrointestinal tract function."
07/01/1999 - "Perflubron emulsion improves tolerance to low-flow ischemia in isolated rabbit hearts."
01/01/1998 - "Treatment with PFOB and/or Vit.E was performed after 60 min of ischemia with 60 min of reperfusion. "
07/01/1998 - "We conclude that during PLV in this lung injury model, (1) gas exchange is improved when compared with gas ventilation, (2) perflubron is distributed predominantly to the dependent regions of the lung, and (3) although gas is distributed throughout the lung with each inspiration, more gas than perflubron goes to the nondependent lung regions."
08/01/2010 - "We conclude that treatment with PFOB-Hi during HFOV compared to a control group in an animal model of lung injury led to regional overdistension of dependent lung areas, as evidenced by increased alveolar overdistension on lung histopathology, decreased mean lung impedance and decreased HFOV-induced regional lung volume changes as measured by EIT."
02/01/2007 - "Near functional residual capacity but not low perflubron dose worsens ventilation-induced lung injury of preinjured lungs. "
11/01/2005 - "Lung injury was induced by repeated saline lavage, after which perflubron was instilled through a side port of the endotracheal tube. "
08/01/2004 - "After induction of lung injury by saline lavage, 25 newborn piglets were randomly assigned to receive 0, 1.25, 2.5, 5.0, or 7.5 mL/kg aerosolized PFOB per hour. "
|1.||perflubron (L 1913)
|5.||tirapazamine (SR 4233)
|7.||salicylhydroxamic acid (SHAM)
|3.||Cardiopulmonary Bypass (Heart-Lung Bypass)
|4.||Positive-Pressure Respiration (PEEP)