ethylene dimethanesulfonate

antispermatogenic agent; structure

Also Known As:

1,2-bis(mesyloxy)ethane; 1,2-bis(methanesulfonyloxy)ethane; 1,2-ethanediol, 1,2-dimethanesulfonate; 1,2-ethanediyl dimethanesulfonate; NSC-10716; ethane 1,2-dimethanesulfonate; ethane dimethane sulfonate; ethane dimethanesulfonate; ethane dimethanesulphonate; ethane dimethyl sulfonate; ethylene dimethane sulfonate; ethanediol 1,2-dimethanesulfonate

Networked: 20 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Acyclic Hydrocarbons
    - Alkanes: 241
      - Alkanesulfonic Acids
        Alkanesulfonates: 9
        Mesylates: 334
        ethylene dimethanesulfonate: 20
- Sulfur Compounds: 278
  - Sulfur Acids
    - Sulfonic Acids: 1605
      - Alkanesulfonic Acids
        Alkanesulfonates: 9
        Mesylates: 334
        ethylene dimethanesulfonate: 20

Experts

1.	Ge, Ren-Shan: 2 articles (12/2021 - 05/2019)
2.	Wang, Yiyan: 2 articles (12/2021 - 05/2019)
3.	Li, Xiaoheng: 1 article (12/2021)
4.	Li, Yang: 1 article (12/2021)
5.	Lin, Liben: 1 article (12/2021)
6.	Wen, Zina: 1 article (12/2021)
7.	Zhang, Song: 1 article (12/2021)
8.	Zou, Cheng: 1 article (12/2021)
9.	Chen, Xiuxiu: 1 article (05/2019)
10.	Fang, Yinghui: 1 article (05/2019)

Related Diseases

1.	Body Weight (Weight, Body) 12/15/2021 - "Fifty-four adult Sprague-Dawley male rats were daily gavaged with PFTeDA (0, 10, or 20 mg/kg body weight) for 10 days, and then were injected intraperitoneally with ethylene dimethane sulfonate (EDS, 75 mg/kg body weight/once) to ablate Leydig cells to induce their regeneration. " 09/01/2004 - "injection of ethane dimethanesulphonate (EDS) in a dose of 75 mg/kg body weight. " 01/01/1997 - "To further localize the cellular sites of the gene expression, the animal model was treated with a single injection of ethylene dimethane sulfonate (EDS) (i.p., 80 mg/kg body weight), a compound known as to specifically eliminate testicular Leydig cells. " 11/01/1989 - "Adult male rats were injected with ethane dimethanesulfonate (EDS; 75 mg/kg body weight) or vehicle. " 07/01/2007 - "To study the androgen-regulated expression of 80-kDa, adult male rats were treated with 75 mg/kg body weight of ethylene dimethane sulfonate (EDS), which selectively destroys Leydig cells and thus induces complete androgen withdrawal. "
2.	Oligospermia (Oligozoospermia) 02/01/2012 - "In this study, we analyzed NDRG2 expression profiles in the testes of normal spermatogenesis patients, hypospermatogenesis patients, and SCO patients, as well as in vivo and in vitro models, which were Sprague-Dawley rats and the Leydig cell line TM3 treated with the Leydig cell-specific toxicant ethane-dimethanesulfonate (EDS). "
3.	Cryptorchidism (Undescended Testes) 12/01/2013 - "Three experiments were performed to examine the regulation of rat Tmsb4x in the epididymis: after elimination of Leydig cells using ethylene dimethane sulfonate (EDS); after destruction of the testis by cryptorchidism; and after castration. " 11/01/1988 - "Immunoreactive inhibin was measured in testicular interstitial fluid (IF) from rats during sexual maturation or after impairment of spermatogenesis induced by ethane dimethanesulphonate (EDS), unilateral cryptorchidism or local heating (43 degrees C, 30 min) of the testes, to ascertain its usefulness as a marker of changing Sertoli cell function. " 05/01/1986 - "To assess the potential physiologic significance of this factor, its effective levels in rat interstitial fluid have been investigated in response to treatments that either markedly reduce interstitial fluid testosterone concentrations (anti-LH treatment; transient or chronic experimental cryptorchidism; destruction of Leydig cells with ethane dimethanesulphonate) or that significantly elevate testosterone levels in interstitial fluid by injection of hCG. " 04/01/1999 - "Experimental cryptorchidism induces a change in the pattern of expression of LH receptor mRNA in rat testis after selective Leydig cell destruction by ethylene dimethane sulfonate."
4.	Congenital Microtia 08/01/2003 - "Effects of gestational exposure to ethane dimethanesulfonate in CD-1 mice: microtia and preliminary hearing tests." 08/01/2003 - "We report microtia in CD-1 mice after gestational exposure to ethane dimethanesulfonate (EDS), an alkylating agent and adult rat Leydig cell toxicant. "
5.	Vitamin A Deficiency 02/01/1993 - "The results show that: (1) the CL at wavelengths of 320 nm (CL320) and 450 nm (CL450) is derived from cholesterol esters and a mixture of lipids including vitamin A esters, respectively; (2) CL320 in the LDs of Leydig cells sharply decreases on postnatal day 21, while CL320 and CL450 in the LDs of Sertoli cells begin to be detectable; (3) the CL450-emitting LDs in seminiferous tubules, whose distributional patterns display cyclic changes during the spermatogenic cycle, are involved in spermatogenesis; and (4) the intensity of CL as well as the distributional patterns of CL-emitting LDs in testicular cells change after hypophysectomy, vitamin-A deficiency, and treatment with ethylene dimethane sulfonate and testosterone propionate. "

Related Drugs and Biologics

1.	Androgens
2.	Testosterone (Sustanon)
3.	Testosterone Propionate
4.	Vitamin A (Retinol)
5.	Messenger RNA (mRNA)
6.	LH Receptors (LH Receptor)
7.	Metals
8.	Lipids
9.	Inhibins (Inhibin)
10.	Esters

Related Therapies and Procedures

1.	Intraperitoneal Injections
2.	Hypophysectomy
3.	Castration