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8-hydroxyadenine

xanthine oxidase reacted adenine metabolite in epidermis of hairless mice; structure

Also Known As:

7,8-DHOA; 7,8-dihydro-8-oxoadenine; 8-oxoadenine

Networked: 10 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Purines: 651
      - Adenine: 2120
        8-hydroxyadenine: 10

Experts

1.	Dizdaroglu, Miral: 3 articles (08/2004 - 08/2002)
2.	Jaruga, Pawel: 3 articles (08/2004 - 08/2002)
3.	Bohr, Vilhelm A: 2 articles (04/2003 - 08/2002)
4.	Rodriguez, Henry: 2 articles (04/2003 - 08/2002)
5.	Tuo, Jingsheng: 2 articles (04/2003 - 08/2002)
6.	Gómez, Francisca: 1 article (11/2021)
7.	Losada Méndez, Jorge: 1 article (11/2021)
8.	Mayorga, Cristobalina: 1 article (11/2021)
9.	Palomares, Francisca: 1 article (11/2021)
10.	Ramos-Soriano, Javier: 1 article (11/2021)

Related Diseases

1.	Neoplasms (Cancer) 12/15/1996 - "We studied six hepatic lesions in immature, neoplasm-free English sole exposed to an urban and reference environment and established correlations between the lesion incidence and concentrations of the mutagenic base modifications 8-hydroxyguanine and 8-hydroxyadenine. " 03/01/2003 - "A weak, but distinct effect of tumor grading and metastatic status was observed in both kinds of tissue in the case of 5-hydroxyuracil, 5-hydroxycytosine, 7,8-dihydro-8-oxoguanine, 7,8-dihydro-8-oxoadenine. "
2.	Cockayne Syndrome (Syndrome, Cockayne) 04/01/2003 - "Primary fibroblasts of Cockayne syndrome patients are defective in cellular repair of 8-hydroxyguanine and 8-hydroxyadenine resulting from oxidative stress." 08/23/2002 - "The cockayne syndrome group B gene product is involved in cellular repair of 8-hydroxyadenine in DNA."
3.	Vaccinia 10/24/2003 - "Site-specific DNA transesterification by vaccinia topoisomerase: effects of benzo[alpha]pyrene-dA, 8-oxoguanine, 8-oxoadenine and 2-aminopurine modifications."
4.	Rupture 01/01/1989 - "Mean radiosensitivity coefficients for the four natural nucleotides and the relative radiation sensitivity of 7,8-dihydro-8-oxoadenine leading to chain rupture in alkaline medium, could be obtained from the band intensities by computer calculation. "
5.	Prostatic Neoplasms (Prostate Cancer) 08/01/2004 - "Using liquid chromatography/mass spectrometry and gas chromatography/mass spectrometry, we show increased levels of oxidative DNA base lesions, 8-hydroxyguanine (8-oxoG), 8-hydroxyadenine (8-oxoA) and 5-hydroxycytosine (5OHC) over the baseline in PC-3 and DU-145 prostate cancer cells following exposure to ionizing radiation and a repair period. "

Related Drugs and Biologics

1.	DNA (Deoxyribonucleic Acid)
2.	8-hydroxyguanine
3.	5-hydroxycytosine
4.	Glucuronides
5.	2-Aminopurine (2 Aminopurine)
6.	Putrescine
7.	Peptides (Polypeptides)
8.	Nucleotides
9.	Ligands
10.	Carnitine (L-Carnitine)