|1.||Marcuzzi, Annalisa: 3 articles (07/2011 - 06/2010)|
|2.||Pontillo, Alessandra: 3 articles (07/2011 - 06/2010)|
|3.||Crovella, Sergio: 3 articles (07/2011 - 06/2010)|
|4.||Satou, Takao: 2 articles (01/2013 - 01/2011)|
|5.||Tsubaki, Masanobu: 2 articles (01/2013 - 01/2011)|
|6.||Imano, Motohiro: 2 articles (01/2013 - 01/2011)|
|7.||Itoh, Tatsuki: 2 articles (01/2013 - 01/2011)|
|8.||Nishida, Shozo: 2 articles (01/2013 - 01/2011)|
|9.||Tommasini, Alberto: 2 articles (07/2011 - 06/2010)|
|10.||Eckert, Gunter P: 1 article (04/2015)|
|1.||Colonic Neoplasms (Colon Cancer)
03/28/2014 - "Interestingly, co-incubation with geranylgeranyl pyrophosphate (GGPP) antagonized the inhibitory impact of simvastatin on colon cancer cell migration triggered by CCL17. "
02/15/2010 - "Mevalonate and geranylgeranyl pyrophosphate eliminated most of the growth inhibitory effect of ATST, but only marginally decreased that of gamma-TT; whereas farnesyl pyrophosphate and squalene exhibited little effect on the inhibitory action of ATST and gamma-TT, indicating protein geranylgeranylation, but not farnesylation are involved in the inhibition of colon cancer cell growth. "
11/01/2010 - "Atorvastatin rapidly induces apoptosis in the HCT116 colon cancer cell line in vitro, and this effect is reversible with mevalonate and geranylgeranyl pyrophosphate, but less so by farnesyl pyrophosphate. "
01/15/2013 - "The present study showed that the induction of apoptosis by N-BPs in hematopoietic tumor cells is mediated by mitochondrial apoptotic signaling pathways, which are activated by the suppression of geranylgeranyl pyrophosphate (GGPP) biosynthesis. "
04/01/2005 - "The effect of GGA on cancer cells was partially prevented by the addition of geranylgeraniol, which is an intermediate of geranylgeranyl pyrophosphate and compensates geranylgeranylation of Rho. "
07/01/2000 - "The diterpene cyclase taxadiene synthase from yew (Taxus) species transforms geranylgeranyl diphosphate to taxa-4(5),11(12)-diene as the first committed step in the biosynthesis of the anti-cancer drug Taxol. "
06/01/1995 - "As a consequence, the isoprenoid-mediated suppression of mevalonate synthesis depletes tumor tissues of two intermediate products, farnesyl pyrophosphate and geranylgeranyl pyrophosphate, which are incorporated posttranslationally into growth control-associated proteins. "
02/01/1995 - "As a consequence, the isoprenoid-mediated suppression of mevalonate synthesis depletes tumor tissues of two intermediate products, farnesyl pyrophosphate and geranylgeranyl pyrophosphate, which are incorporated post-translationally into growth control-associated proteins."
05/01/1999 - "These studies demonstrate that protein geranylgeranylation but not farnesylation is important for osteoclast-mediated bone resorption and that nitrogen-containing bisphosphonates exert their antiresorptive action probably by affecting enzymes of the mevalonate pathway involved in the generation of geranylgeranyl pyrophosphate."
04/01/1998 - "Furthermore, alendronate-induced apoptosis, like mevastatin-induced apoptosis, could be suppressed in J774 cells by the addition of farnesyl pyrophosphate or geranylgeranyl pyrophosphate, while the effect of alendronate on osteoclast number and bone resorption in murine calvariae in vitro could be overcome by the addition of mevalonic acid. "
|4.||Experimental Autoimmune Encephalomyelitis (Encephalomyelitis, Autoimmune Experimental)
|5.||Breast Neoplasms (Breast Cancer)
10/01/2011 - "Geranylgeranyl diphosphate depletion inhibits breast cancer cell migration."
10/01/2011 - "The objective of this study was to determine whether geranylgeranyl diphosphate synthase inhibition, and therefore geranylgeranyl diphosphate depletion, interferes with breast cancer cell migration. "
|1.||Mevalonic Acid (Mevalonate)
|2.||farnesyl pyrophosphate (farnesyl diphosphate)
|10.||Proteins (Proteins, Gene)