ketodihydrosphingosine

RN given refers to cpd without isomeric designation

Also Known As:

(+-)-isomer of ketodihydrosphingosine; (S)-isomer of ketodihydrosphingosine; 1-hydroxy-2-amino-3-oxo-octadecane; 3-ketodihydrosphingosine; 3-ketosphinganine

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Amines: 4871
  - Amino Alcohols: 20
    - Sphingosine: 899
      - ketodihydrosphingosine: 2
- Alcohols: 595
  - Glycols: 38
    - Sphingosine: 899
      - ketodihydrosphingosine: 2
  - Amino Alcohols: 20
    - Sphingosine: 899
      - ketodihydrosphingosine: 2

Experts

1.	Adachi, Ryutaro: 1 article (01/2018)
2.	Aoyama, Kazunobu: 1 article (01/2018)
3.	Arai, Ryosuke: 1 article (01/2018)
4.	Asano, Yasutomi: 1 article (01/2018)
5.	Hirata, Yasuhiro: 1 article (01/2018)
6.	Hirayama, Megumi: 1 article (01/2018)
7.	Hiura, Yuto: 1 article (01/2018)
8.	Imamura, Shinichi: 1 article (01/2018)
9.	Iwamura, Naoki: 1 article (01/2018)
10.	Kiba, Atsushi: 1 article (01/2018)

Related Diseases

Neoplasms (Cancer)

04/01/2016 - "In this article we show that 3-ketosphinganine (KSa) and its dideuterated analog at C4 (d2KSa) are metabolized to produce high levels of dihydrosphingolipids in HGC27, T98G and U87MG cancer cells. "
04/01/2016 - "3-Ketosphinganine provokes the accumulation of dihydroshingolipids and induces autophagy in cancer cells."
01/01/2018 - "Reduction of 3-ketodihydrosphingosine, the direct downstream product of SPT, was confirmed under in vivo settings after oral administration of compounds 4 and 5. Their anti-tumor efficacy was observed in a PL-21 xenograft mouse model. "

Related Therapies and Procedures

1.	Oral Administration