2-amino-3-chlorobutyric acid

RN given refers to cpd without isomeric designation; structure

Also Known As:

TACB; alpha-amino-beta-chlorobutyrate; alpha-amino-beta-chlorobutyrate, (R*,R*)-(+-)-isomer; alpha-amino-beta-chlorobutyrate, threo(R-(R*,R*))-isomer; butanoic acid, 2-amino-3-chloro-

Networked: 14 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Carboxylic Acids: 973
  - Acyclic Acids
    - Butyrates: 2613
      - Aminobutyrates: 1253
        2-amino-3-chlorobutyric acid: 14
Amino Acids, Peptides, and Proteins: 1
- Amino Acids: 30675
  - Aminobutyrates: 1253
    - 2-amino-3-chlorobutyric acid: 14

Experts

1.	Rozados, V R: 5 articles (01/2012 - 05/2000)
2.	Matar, P: 4 articles (01/2012 - 05/2000)
3.	Scharovsky, O G: 4 articles (01/2012 - 05/2000)
4.	Matar, Pablo: 3 articles (08/2012 - 01/2002)
5.	Scharovsky, O Graciela: 3 articles (08/2012 - 02/2007)
6.	Rico, María J: 2 articles (01/2010 - 02/2007)
7.	Zacarías Fluck, Mariano F: 2 articles (01/2010 - 02/2007)
8.	Rabinovich, Gabriel A: 2 articles (02/2007 - 01/2002)
9.	Gervasoni, S I: 2 articles (10/2004 - 02/2001)
10.	Rico, Maria J: 1 article (08/2012)

Related Diseases

1.	Lymphoma (Lymphomas) 01/01/2012 - "with L-TACB lymphoma and on day 14 animals were distributed in two groups. " 01/01/2010 - "Here, we examined whether the immune response is responsible for the antitumor effect of MCT with Cy on L-TACB lymphoma. " 01/01/1990 - "L-TACB is a spontaneous poorly differentiated lymphoma that appeared in the peritoneal cavity of a rat of the inbred line e; since 1969 it has been maintained by subcutaneous grafting in e rats. " 01/01/1989 - "The subcutaneous challenge of eR and eS rats with Lymphoma TACB (L-TACB) showed a different behavior. " 10/01/2004 - "Adult inbred rats were challenged with lymphoma TACB and sarcoma E100 s.c. "
2.	Neoplasms (Cancer) 01/01/1998 - "The adoptive transfer of splenocytes from Cy-treated tumor-bearing rats, together with L-TACB cells inhibited their metastatic growth. " 01/01/1989 - "It was observed, using animals of different genotypes, that susceptibility to L-TACB metastases and to local tumor growth, would be conditioned by different genes. " 01/01/1989 - "A tumor-host interaction was found, revealing that genotypes resistant to S-E 100 were susceptible to L-TACB; in addition, susceptible animals (eR) developed lymph node metastases. " 02/01/1999 - "Considering the scarcity of therapeutic resources against metastasis, our objective was to study LOV as an antimetastatic agent on L-TACB rat lymphoma, which as a syngeneic tumor model resembles more closely the situation in human cancer. " 09/01/1997 - "The influence of the tumor-host interaction on the induction of angiogenesis was studied in a tumor model-system composed by two lines of rats selected for resistance or susceptibility to a sarcoma (S-E100) and two transplantable tumors: Sarcoma E 100 and Lymphoma TACB. "
3.	Neoplasm Metastasis (Metastasis) 02/01/1999 - "These effects could explain, at least in part, the inhibitory action of LOV on L-TACB rat lymphoma metastases." 01/01/1989 - "It was observed, using animals of different genotypes, that susceptibility to L-TACB metastases and to local tumor growth, would be conditioned by different genes. " 02/01/1999 - "Considering the scarcity of therapeutic resources against metastasis, our objective was to study LOV as an antimetastatic agent on L-TACB rat lymphoma, which as a syngeneic tumor model resembles more closely the situation in human cancer. " 01/01/1990 - "For the purpose of investigating the influence of the host genotype in the metastatic process, the frequency of lymph nodes metastases of a transplantable rat lymphoma (L-TACB) in relation to tumor growth and to capacity of rejection was studied in the inbred lines m, eR and eS and in the F1 hybrids m x eR, m x eS and eR x eS. " 02/01/2001 - "In previous reports, we demonstrated an inhibitory effect of a single low-dose of cyclophosphamide (Cy) on spontaneous and experimental metastasis of a rat lymphoma (L-TACB). "
4.	Sarcoma (Soft Tissue Sarcoma) 10/01/2004 - "Adult inbred rats were challenged with lymphoma TACB and sarcoma E100 s.c. " 09/01/1997 - "The influence of the tumor-host interaction on the induction of angiogenesis was studied in a tumor model-system composed by two lines of rats selected for resistance or susceptibility to a sarcoma (S-E100) and two transplantable tumors: Sarcoma E 100 and Lymphoma TACB. "
5.	B-Cell Lymphoma (Lymphoma, B Cell) 08/01/2012 - "We have already shown that IL-10 plays an important role in immunosuppression and metastatic dissemination in the rat B-cell lymphoma L-TACB model. "

Related Drugs and Biologics

1.	Cyclophosphamide (Cytoxan)
2.	Interleukin-10 Receptors
3.	Intercellular Signaling Peptides and Proteins (Growth Factors)
4.	Interleukin-10 (Interleukin 10)
5.	Proteins (Proteins, Gene)
6.	Lovastatin (Mevacor)
7.	Neoplasm Antigens (Tumor Antigens)
8.	1-nitrohydroxyphenyl-N-benzoylalanine (GAL 1)