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ovalicin

sesquiterpene isolated from culture filtrate of fungus Pseudorotium ovalis; shows antitumor activity; structure

Networked: 7 relevant articles (2 outcomes, 1 trials/studies)

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Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Terpenes: 1461
    - Sesquiterpenes: 1370
      - ovalicin: 7

Experts

1.	Hwang, Sung-Hyun: 1 article (06/2021)
2.	Jeong, Yeji: 1 article (06/2021)
3.	Kim, Yongbaek: 1 article (06/2021)
4.	Yang, Yeseul: 1 article (06/2021)
5.	Jeon, Ji-Young: 1 article (01/2011)
6.	Lee, Hei-Sam: 1 article (01/2011)
7.	Lee, Myeong-Lyeol: 1 article (01/2011)
8.	Lee, Sang-Han: 1 article (01/2011)
9.	Nam, Sung-Hee: 1 article (01/2011)
10.	Son, Hyeong-U: 1 article (01/2011)

Related Diseases

1.	Infections 06/01/2006 - "The purpose of this study was to apply an in vitro drug screening assay for Encephalitozoon intestinalis and Vittaforma corneae and an in vivo athymic mouse model of V. corneae infection to assess the efficacy of TNP-470 (a semisynthetic analogue of fumagillin), ovalicin, and eight ovalicin derivatives. " 06/01/2006 - "None of the treated athymic mice survived the V. corneae infection, but they did survive statistically significantly longer than the untreated controls after daily treatment with fumagillin administered at 5, 10, and 20 mg/kg of body weight subcutaneously (s.c.), TNP-470 administered at 20 mg/kg intraperitoneally (i.p.), or ovalicin administered at 5 mg/kg s.c. "
2.	Atopic Dermatitis (Atopic Eczema) 01/01/2011 - "Ovalicin ameliorates compound 48/80-induced atopic dermatitis-related symptoms." 06/16/2021 - "Ovalicin attenuates atopic dermatitis symptoms by inhibiting IL-31 signaling and intracellular calcium influx." 01/01/2011 - "To assess whether ovalicin has potential in ameliorating atopic dermatitis-related symptoms in mice, we first sensitized skin in the dorsal neck of Balb/c mice using compound 48/80, and scrutinized whether the compound affected the atopic dermatitis-related symptoms. "
3.	Microsporidiosis 05/01/2005 - "Fumagillin, ovalicin and their analogues have been demonstrated to have antimicrosporidial activity in vitro and in animal models of microsporidiosis. "
4.	Neoplasms (Cancer) 10/13/1998 - "It previously has been shown that the type II enzyme is the molecular target of fumagillin and ovalicin, two epoxide-containing natural products that inhibit angiogenesis and suppress tumor growth. "
5.	Experimental Melanoma 07/01/1996 - "Chlovalicin, a ovalicin derivative with a chlorinated methylene moiety at the C-1 position of the cyclohexane ring, dose-dependently inhibited the growth of IL-6 dependent MH60 cells (IC50, 7.5 microM) in the presence of 0.2 U/ml IL-6 and, to a lesser extent, the growth of B16 melanoma cells (IC50, 38 microM). "

Related Drugs and Biologics

1.	fumagillin
2.	O-(Chloroacetylcarbamoyl)fumagillol (TNP 470)
3.	p-Methoxy-N-methylphenethylamine
4.	Interleukin-6 (Interleukin 6)
5.	Thymidine
6.	Lipopolysaccharides
7.	Epoxy Compounds (Epoxides)
8.	Enzymes
9.	DNA (Deoxyribonucleic Acid)
10.	Dexamethasone (Maxidex)