norpropoxyphene

08/01/1984 - "Detection, identification and measurement of dextropropoxyphene and its principal plasma metabolite, nordextropropoxyphene, can be important in the diagnosis of acute poisoning. "
02/01/1977 - "Post-mortem concentrations of dextropropoxyphene (DP) and its major metabolite norpropoxyphene (NP) were determined by combined gas-liquid chromatography and thin-layer chromatography in autopsy material from 53 cases of fatal DP poisoning collected over a 1-year period. "
02/01/1977 - "Dextropropoxyphene and norpropoxyphene in blood, muscle, liver and urine in fatal poisoning."
01/01/1976 - "Out of 14 cases of poisoning assumed to be due to dextropropoxyphene-containing drugs, propoxyphene and its main metabolite norpropoxyphene could be demonstrated in 11. "
01/01/1978 - "In an attempt to relate the clinical events to the plasma concentrations of DP and the major metabolite norpropoxyphene (NP) we studied patients with acute poisoning treated either for 48 h with induced hypocapnia by hyperventilation or under a conservative regime. "

05/01/1980 - "These differences, which appear to result from decreased presystemic biotransformation of propoxyphene and decreased elimintation of norpropoxyphene, indicate that propoxyphene should be used cautiously and at reduced doses in patients with renal failure."
09/01/1980 - "A woman with portacaval shunt and essentially complete renal failure was also studied; she exhibited the highest propoxyphene peak concentration in this investigation and had no detectable norpropoxyphene in plasma. "
02/01/1978 - "Renal failure and relatively high concentrations of d-norpropoxyphene, the major metabolite of d-propoxyphene, have no significant effect on the plasma protein binding of d-propoxyphene."

12/01/1999 - "Norpropoxyphene-induced cardiotoxicity is associated with changes in ion-selectivity and gating of HERG currents."
10/01/1987 - "Furthermore, convulsions have been associated with normeperidine and cardiac toxicities with norpropoxyphene. "

11/01/2008 - "Dextropropoxyphene (DP) and norpropoxyphene (NP) are commonly used in the treatment of postpartum pain. "
05/01/2010 - "Urine samples from 4,200 pain patients were tested by immunoassay and LC-MS/MS for the following drugs and metabolites: Amphetamine, Methamphetamine, Alpha-hydroxyalprazolam, Lorazepam, Nordiazepam, Oxazepam, Temazepam, Cannabinoids, Cocaine, Methadone, Methadone Metabolite, Codeine, Hydrocodone, Hydromorphone, Morphine, Propoxyphene, and Norpropoxyphene. "

11/01/2008 - "Retrospective diagnosis of an adverse drug reaction in a breastfed neonate: liquid chromatography-tandem mass spectrometry quantification of dextropropoxyphene and norpropoxyphene in newborn and maternal hair."