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ethyldiphacil
Russian drug; RN given refers to parent cpd
Also Known As:
IEM-506; eterofen; ethyldiphacil monohydrochloride; ethyldiphenacetate; 1-ethyl-2-(diethylamino)ethyl diphenylacetate
Networked:
3
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Organic Chemicals: 133
Carboxylic Acids: 973
Carbocyclic Acids
Phenylacetates: 3
Diphenylacetic Acids
ethyldiphacil: 3
Related Diseases
1.
Parkinsonian Disorders (Parkinsonism)
01/01/1985 - "
Using experimental models of parkinsonism, imitating the hypertonus of the parasympathetic system (hypokinesia, rigidity and tremor) following the intraperitoneal injection of the acetylcholinesterase inhibitor galanthamin (15 mg/kg) to mice, the authors showed that the m-cholinoblocker metamisyl (2 mg/kg) blocks all manifestations of the CNS parasympathetic hypertonus whereas the n-cholinoblocker eterofen (30 mg/kg) increases them.
"
2.
Hypokinesia (Bradykinesia)
01/01/1985 - "
Using experimental models of parkinsonism, imitating the hypertonus of the parasympathetic system (hypokinesia, rigidity and tremor) following the intraperitoneal injection of the acetylcholinesterase inhibitor galanthamin (15 mg/kg) to mice, the authors showed that the m-cholinoblocker metamisyl (2 mg/kg) blocks all manifestations of the CNS parasympathetic hypertonus whereas the n-cholinoblocker eterofen (30 mg/kg) increases them.
"
3.
Tremor (Tremors)
01/01/1985 - "
Using experimental models of parkinsonism, imitating the hypertonus of the parasympathetic system (hypokinesia, rigidity and tremor) following the intraperitoneal injection of the acetylcholinesterase inhibitor galanthamin (15 mg/kg) to mice, the authors showed that the m-cholinoblocker metamisyl (2 mg/kg) blocks all manifestations of the CNS parasympathetic hypertonus whereas the n-cholinoblocker eterofen (30 mg/kg) increases them.
"
4.
Hypertrophy
04/01/1978 - "
Treatment of hemicastrated adult female rats with nicotine increased the compensatory ovarian hypertrophy (COH) while central n-cholinolytic IEM-506 decreased COH and prevented the estrogen-induced suppression of COH.
"
5.
Epilepsy (Aura)
04/01/1986 - "
Chronic experiments on rabbits with penicillin epilepsy have shown that intravenous injections of the ACHE inhibitor galanthamine (1 mg/kg), and N-cholinergic-blockers, ganglerone (3 mg/kg) and eterofen (8 mg/kg), decreased or suppressed completely epileptogenesis manifestations.
"
Related Drugs and Biologics
1.
Cholinergic Antagonists (Anticholinergics)
2.
Cholinergic Agents (Cholinergics)
3.
Penicillins (Penicillin)
4.
Nicotine
5.
Galantamine (Galanthamine)
6.
Estrogens (Estrogen)
7.
Cholinesterase Inhibitors (Anticholinesterases)
8.
ganglerone
Related Therapies and Procedures
1.
Intravenous Injections
2.
Intraperitoneal Injections