|1.||Kondoh, Masuo: 6 articles (11/2005 - 10/2003)|
|2.||Fujii, Makiko: 6 articles (11/2005 - 10/2003)|
|3.||Watanabe, Yoshiteru: 6 articles (11/2005 - 10/2003)|
|4.||Asakawa, Yoshinori: 6 articles (11/2005 - 10/2003)|
|5.||Nagashima, Fumihiro: 6 articles (11/2005 - 10/2003)|
|6.||Suzuki, Ikue: 5 articles (11/2005 - 05/2004)|
|7.||Harada, Motoki: 4 articles (11/2005 - 08/2004)|
|8.||Sun, Han-Dong: 2 articles (11/2014 - 07/2010)|
|9.||Takeya, Koichi: 2 articles (09/2006 - 03/2004)|
|10.||Aoyagi, Yutaka: 2 articles (09/2006 - 03/2004)|
|1.||Hepatocellular Carcinoma (Hepatoma)
01/01/2013 - "Studies have shown that classes of kaurene diterpene have anti-tumor activity related to their ability to induce apoptosis. "
07/15/2010 - "Pharicin A, a novel natural ent-kaurene diterpenoid, induces mitotic arrest and mitotic catastrophe of cancer cells by interfering with BubR1 function."
07/15/2010 - "In this study, we report the functional characterization of a new ent-kaurene diterpenoid termed pharicin A, which was originally isolated from Isodon, a perennial shrub frequently used in Chinese folk medicine for tumor treatment. "
12/08/2006 - "Kaurene diterpenes from Laetia thamnia inhibit the growth of human cancer cells in vitro."
11/01/2005 - "Thus, some of these new ent-kaurene-type diterpenoids may be promising candidates for anti-tumor agents."
|3.||Dehydration (Water Stress)
11/01/2010 - "This recombinant AtKO (rAtKO) was used to carry out 18O2 labelling studies with ent-kaurene, and the intermediates ent-kaurenol and ent-kaurenal, to investigate the multifunctional reaction sequence; revealing catalysis of three hydroxylation reactions, which further requires dehydration at some stage. "
10/01/2004 - "We previously found that an Ent-kaurene diterpene, Ent-11alpha-hydroxy-16-kauren-15-one (KD), induced apoptosis in human promyelocytic leukemia HL-60 cells. "
10/01/2004 - "Kaurene diterpene induces apoptosis in human leukemia cells partly through a caspase-8-dependent pathway."
09/01/2006 - "The structure and cytotoxic activity relationships (SAR) of the natural parent ent-kaurene diterpenes and these semisynthetic analogues were studied by using P388 murine leukemia cells."
11/01/2005 - "Previously, we have focused our research on the apoptosis-inducing properties of diterpenoids and found that some ent-kaurene-type diterpenoids induced apoptosis in human leukemia HL-60 cells. "
03/01/2005 - "Indeed, we have found that an ent-kaurene diterpene, ent-11alpha-hydroxy-16-kauren-15-one (KD), induced apoptosis via caspase-8 activation in human promyelocytic leukemia HL-60 cells. "
|5.||Cysteine Proteases (Cysteine Protease)
|6.||Caspase 8 (Caspase-8)
|7.||Reactive Oxygen Species (Oxygen Radicals)
|8.||NF-kappa B (NF-kB)
|9.||Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
|1.||Traditional Medicine (Folk Remedies)