costunolide

01/01/2017 - "Moreover, isocostunolide damaged GSCs colony formation capacity significantly and exhibited the anti-cancer efficacy against GSCs in vitro."
02/08/2007 - "In this study, we found isocostunolide could effectively induce cytotoxicity in three cancer cell lines (A2058, HT-29, and HepG2), with an IC(50) of 3.2, 5.0, and 2.0 micro g/mL, respectively. "
07/13/2021 - "Costunolide (CTD) possesses potential anticancer and bioactive abilities that have been confirmed in several types of cancers. "
02/19/2021 - "Taken together, our data clearly indicated that costunolide exerts anti-cancer activity in A431 cells by suppressing cell growth via inhibition of proliferation and promotion of apoptosis. "
01/01/2017 - "In this investigation, the anti-tumor activity of isocostunolide against GSCs was investigated and the result demonstrated that it inhibited the growth of GSCs (GSC-3#, GSC-12#, GSC-18#) significantly with an IC50 value of 2.80μg/ml, 2.61μg/ml, 1.07μg/ml, respectively. "

01/01/2023 - "Numerous studies indicate that costunolide (Cos) can reduce inflammation. "
09/09/2023 - "Taken together, these results demonstrated that costunolide could attenuate gram-negative bacterial induced inflammation and diseases and might be a potential candidate for the treatment of inflammatory diseases."
09/09/2023 - "Costunolide has been reported to possess excellent anti-inflammatory activity; however, whether it can affect inflammation induced by gram-negative bacterial is still unclear. "
03/01/2022 - "Costunolide protects against alcohol-induced liver injury by regulating gut microbiota, oxidative stress and attenuating inflammation in vivo and in vitro."
09/09/2023 - "Costunolide attenuates LPS-induced inflammation and lung injury through inhibiting IKK/NF-κB signaling."

12/01/2021 - "It is worth mentioning that costunolide and dehydrocostus lactone, which were the common representative compounds of "Muxiang" species, showed antiinflammatory, anticancer, anti-gastric ulcers, and liver protective effects. "
11/01/2018 - "Pharmacokinetics of costunolide and dehydrocostuslactone after oral administration of Radix aucklandiae extract in normal and gastric ulcer rats."
04/25/2016 - "Evaluation of protective effects of costunolide and dehydrocostuslactone on ethanol-induced gastric ulcer in mice based on multi-pathway regulation."
04/25/2016 - "The aim of the present study was to evaluate the anti-ulcerogenic activity of costunolide (Co) and dehydrocostuslactone (De) on ethanol-induced gastric ulcer in mice and to elucidate the potential mechanisms of the action involved. "

10/01/2015 - "The present study aims to evaluate the anticancer property of costunolide isolated from Costus speciosus against breast cancer cell lines (MCF-7 and MDA-MB-231). "
04/01/2012 - "Through this study we confirm that costunolide induces G2/M cell cycle arrest and apoptotic cell death via extrinsic pathway in MDA-MB-231 cells suggesting that it could be a promising anticancer drug especially for ER-negative breast cancer."
01/15/2004 - "In this study we showed that costunolide exerts a dose-dependent antiproliferative activity in the human breast cancer MCF-7 cells. "
10/01/2015 - "Thus costunolide effectively induced breast cancer cell apoptosis targeting cell cycle regulation, and the compound can be used as an effective herbal therapeutic molecule to treat breast cancer with further explorations."
10/01/2015 - "Cytotoxic Impact of Costunolide Isolated from Costus speciosus on Breast Cancer via Differential Regulation of Cell Cycle-An In-vitro and In-silico Approach."

09/01/2018 - "Together, these results demonstrate that costunolide may be a potent therapeutic agent against chronic myeloid leukemia."
02/01/2021 - "To explore the effects of costunolide on the proliferation and apoptosis of human chronic myeloid leukemia drug resisitant cell line K562/ADR and its mechanism. "
04/01/2020 - "To investigate the inhibitory effect of costunolide on the proliferation of human chronic myeloid leukemia cell line K562 cells and the underlying mechanisms. "
06/01/2019 - "The current study was designed to evaluate the effect of costunolide on sensitivity of K562/ADR chronic myeloid leukemia cells to doxorubicin. "
09/01/2018 - "In the present study, we assessed the antileukemia effects of costunolide on the human chronic myeloid leukemia cell line K562 and its combined activity with imatinib. "