|1.||Choi, Jung-Hye: 5 articles (12/2011 - 08/2002)|
|2.||Lee, Kyung-Tae: 5 articles (12/2011 - 08/2002)|
|3.||Park, Hee-Juhn: 4 articles (01/2011 - 08/2002)|
|4.||Roy, Anita: 2 articles (10/2015 - 10/2014)|
|5.||Pitchai, Daisy: 2 articles (10/2014 - 01/2011)|
|6.||Shin, Yong Cheol: 2 articles (01/2013 - 04/2012)|
|7.||Choi, Youn Kyung: 2 articles (01/2013 - 04/2012)|
|8.||Ko, Seong-Gyu: 2 articles (01/2013 - 04/2012)|
|9.||Lee, Sung-Jin: 2 articles (01/2012 - 09/2011)|
|10.||Mar, Woongchon: 2 articles (01/2012 - 09/2011)|
04/01/2015 - "These results suggest that dehydrocostus lactone and costunolide are promising candidates for being developed into novel anticancer drugs effective against neuroblastoma. "
04/01/2015 - "To clarify the anticancer effects of the sesquiterpene lactones dehydrocostus lactone and costunolide, derived from Saussurea lappa, we examined the cytotoxic and migration/invasion-inhibitory effects of these compounds against neuroblastoma cell lines. "
07/30/2009 - "The oral administration of EEMO, DCM and costunolide inhibited carrageenan (Cg)-induced paw oedema (ID(50) 72.35 (38.64-135.46) mg/kg, 5.8 (2.41-14.04) mg/kg and 0.18 (0.12-0.27) mg/kg, respectively) and was effective in abolishing lipopolysaccharide (LPS)-induced fever (30 mg/kg, 4.5 mg/kg and 0.15 mg/kg, respectively). "
|3.||Breast Neoplasms (Breast Cancer)
10/01/2015 - "The present study aims to evaluate the anticancer property of costunolide isolated from Costus speciosus against breast cancer cell lines (MCF-7 and MDA-MB-231). "
04/01/2012 - "Through this study we confirm that costunolide induces G2/M cell cycle arrest and apoptotic cell death via extrinsic pathway in MDA-MB-231 cells suggesting that it could be a promising anticancer drug especially for ER-negative breast cancer."
01/15/2004 - "In this study we showed that costunolide exerts a dose-dependent antiproliferative activity in the human breast cancer MCF-7 cells. "
10/01/2015 - "Thus costunolide effectively induced breast cancer cell apoptosis targeting cell cycle regulation, and the compound can be used as an effective herbal therapeutic molecule to treat breast cancer with further explorations. "
10/01/2015 - "Cytotoxic Impact of Costunolide Isolated from Costus speciosus on Breast Cancer via Differential Regulation of Cell Cycle-An In-vitro and In-silico Approach."
03/01/2001 - "In this study, we investigate the effects of costunolide on the induction of apoptosis in HL-60 human leukemia cells and its putative pathways of action. "
08/15/2006 - "While compounds 4e, 4g, and 4p have shown around 2- to 3-fold better cytotoxicity against MIAPaCa2 (pancreas), K-562 (leukemia) and PA-1 (ovary) cell lines as well as better safety index in comparison to costunolide (1). "
10/15/2002 - "In this report, we investigated the effect of costunolide on cellular differentiation in the human promyelocytic leukemia HL-60 cell culture system. "
08/01/2002 - "These results, accompanied by a decline in the expression of c-myc protein, suggest that costunolide induces differentiation of human leukemia cells to granulocytes and monocytes/macrophages lineage."
08/01/2002 - "This work investigated the mechanism of the antiproliferative effect of costunolide and determined that it induced differentiation of the human leukemia cell line HL-60. "
02/08/2007 - "In this study, we found isocostunolide could effectively induce cytotoxicity in three cancer cell lines (A2058, HT-29, and HepG2), with an IC(50) of 3.2, 5.0, and 2.0 micro g/mL, respectively. "
10/01/2015 - "The above results were validated with in-silico results that predicted stable interactions between costunolide and cancer targets. "
10/01/2015 - "Costunolide mediated downregulation of positive cell cycle regulators and upregulation of negative cell cycle regulators were related to the induction of apoptosis in cancer cells. "
09/10/2015 - "Analogues 32 and 45 maintained high activities against a series of cancer cell lines compared to their parent PTL and costunolide, respectively. "
10/01/2014 - "The over expressed NF-κB subunits - p65, 52 and 100 in the cancer cells were found to be downregulated when treated with costunolide at an effective dose of 20 and 40 μM costunolide. "
|4.||Mitogen-Activated Protein Kinases
|5.||Sulfhydryl Compounds (Thiols)
|9.||dynorphin A-converting enzyme
|10.||Nitric Oxide Synthase Type II (Inducible Nitric Oxide Synthase)