|1.||Bible, Keith C: 2 articles (05/2009 - 03/2007)|
|2.||Tibodeau, Jennifer D: 2 articles (05/2009 - 03/2007)|
|3.||Isham, Crescent R: 2 articles (05/2009 - 03/2007)|
|4.||Tsuda, Hiromasa: 1 article (12/2015)|
|5.||Ochiai, Kuniyasu: 1 article (12/2015)|
|6.||Murofushi, Takahisa: 1 article (12/2015)|
|7.||Imai, Kenichi: 1 article (12/2015)|
|8.||Yang, Pishan: 1 article (12/2015)|
|9.||Zhao, Ning: 1 article (12/2015)|
|10.||Suzuki, Naoto: 1 article (12/2015)|
02/01/2013 - "In this study, we demonstrated that treatment with chaetocin enhanced apoptosis in human leukemia HL60, KG1, Kasumi, K562, and THP1 cells. "
04/01/2012 - "We report here that pharmacological inhibition of SUV39H1 by chaetocin induces apoptosis in leukemia cell lines in vitro and primary AML cells ex vivo, and that it interferes with leukemia growth in vivo. "
02/01/2013 - "Importantly, co-treatment with chaetocin and TSA produced potent antileukemic effects in leukemia cells derived from patients. "
04/01/2012 - "Anti-leukemia activity of chaetocin via death receptor-dependent apoptosis and dual modulation of the histone methyl-transferase SUV39H1."
02/01/2013 - "Improved therapeutic effect against leukemia by a combination of the histone methyltransferase inhibitor chaetocin and the histone deacetylase inhibitor trichostatin A."
01/01/2014 - "Chaetocin-treated tumors exhibited heightened ROS, pATM, YAP1 and pJNK levels. "
02/01/2013 - "Chaetocin specifically inhibits SUV39H1, resulted in H3K9 methylation reduction as well as reactivation of silenced genes in cancer cells. "
01/01/2011 - "Such an effect of chaetocin was not observed in cell lines derived from normal cells, and was cell type-dependent even among cancer cell lines. "
01/01/2011 - "Here we examined whether chaetocin has anticancer activities against solid tumors. "
05/01/2009 - "We recently reported that the antineoplastic thiodioxopiperazine natural product chaetocin potently induces cellular oxidative stress, thus selectively killing cancer cells. "
01/01/2014 - "Chaetocin induced glioma cell apoptosis in a ROS-dependent manner. "
01/01/2014 - "As elevating basal ROS level sensitizes glioma cells to apoptosis, the ability of Chaetocin in regulating apoptotic and metabolic adaptive responses in glioma was investigated. "
01/01/2014 - "Coherent with the in vitro findings, Chaetocin reduced tumor burden in heterotypic xenograft glioma mouse model. "
02/01/2014 - "We found that VPA and TSA increase histone H4 acetylation in glioma cells, while chaetocin and BIX01294 at low concentrations reduce H3K9me3, and 3DZNep decreases H3K27me3. "
01/17/2012 - "Further, Molt-4 rho(0) cells lacking metabolically functional mitochondria were readily killed by chaetocin; in addition chaetocin-induced cytotoxicity was unaffected by autophagy inhibitors or hypoxia and consequent HIF-1α upregulation. "
01/17/2012 - "The anticancer effects of chaetocin are independent of programmed cell death and hypoxia, and are associated with inhibition of endothelial cell proliferation."
01/01/2011 - "Antihepatoma activity of chaetocin due to deregulated splicing of hypoxia-inducible factor 1α pre-mRNA in mice and in vitro."
01/01/2011 - "Immunohistochemical analyses revealed that chaetocin inhibits hypoxia-inducible factor-1α (HIF-1α) expression and vessel formation in the tumors. "
|5.||Acute Myeloid Leukemia (Acute Myelogenous Leukemia)
|1.||Histone Deacetylase Inhibitors
|3.||trichostatin A (A 300)
|5.||TNF-Related Apoptosis-Inducing Ligand Receptors
|6.||Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)
|8.||Messenger RNA (mRNA)
|9.||RNA Precursors (Precursor, mRNA)
|10.||RNA (Ribonucleic Acid)
|1.||Heterologous Transplantation (Xenotransplantation)