4-nitrophenyl 4'-guanidinobenzoate

kallikrein substrate; acrosin antagonist in sperm; serine esterase inhibitor; RN given refers to parent cpd; structure

Also Known As:

4-nitrophenyl 4'-guanidinobenzoate, hydrochloride; 4-nitrophenyl p'-guanidinobenzoate; p-nitrophenyl p'-guanidinobenzoate; para-nitrophenyl p'-guanidinobenzoate

Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Aromatic Hydrocarbons: 291
      - Benzene Derivatives: 17
        Benzoates: 426
        4-nitrophenyl 4'-guanidinobenzoate: 3
- Carboxylic Acids: 973
  - Carbocyclic Acids
    - Benzoates: 426
      - 4-nitrophenyl 4'-guanidinobenzoate: 3

Related Diseases

1.	Wounds and Injuries (Trauma) 10/15/1991 - "The B-SK was complexed with p-nitrophenyl-p-guanidinobenzoate; it did not activate the plasminogen or inhibit tumor formation in the hepatic wounds. "
2.	Sexually Transmitted Diseases (Sexually Transmitted Disease) 04/01/1980 - "This protease activity was inhibited by soybean trypsin inhibitor (STI), benzamidine and (p-nitrophenyl)-p'-guanidinobenzoate (NPGB), and was insensitive to 1-chloro-3-tosylamido-7-amino-2-heptanone (TLCK) and p-hydroxymercuribenzoic acid (HMB). "
3.	Neoplasms (Cancer) 10/15/1991 - "The B-SK was complexed with p-nitrophenyl-p-guanidinobenzoate; it did not activate the plasminogen or inhibit tumor formation in the hepatic wounds. "
4.	Renal Cell Carcinoma (Grawitz Tumor) 07/01/1992 - "The main features of the guanidinobenzoatase associated with human renal carcinoma plasma membrane are weak membrane association, continuous cleavage of p-nitrophenyl-p'-guanidinobenzoate conversely to the site titration effect of this compound when used with trypsin, and a peculiar sensitivity to serine protease inhibitors, compatible with a poorly active form. "

Related Drugs and Biologics

1.	Serine Proteinase Inhibitors (Serine Protease Inhibitors)
2.	Trypsin Inhibitors
3.	Trypsin
4.	Tosyllysine Chloromethyl Ketone
5.	Plasminogen
6.	Peptide Hydrolases (Proteases)
7.	guanidinobenzoate esterase
8.	benzamidine
9.	4-hydroxymercuribenzoate