4-oxoretinoic acid

RN given refers to cpd without isomeric designation; structure

Also Known As:

4-ketoretinoic acid; 4-oxo-13-cis-retinoic acid; 4-oxo-isotretinoin; 4-oxo-trans-retinoic acid; 4-oxoretinoic acid, (13-cis)-isomer; Ro 12-4824

Networked: 10 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Cho, Hwang Eui: 1 article (12/2014)
2.	Kang, Min H: 1 article (12/2014)
3.	Reynolds, C Patrick: 1 article (12/2014)
4.	Sonawane, Poonam: 1 article (12/2014)
5.	Tagde, Ashujit: 1 article (12/2014)
6.	Verlekar, Dattesh: 1 article (12/2014)
7.	Yu, Alice L: 1 article (12/2014)
8.	Grønhøj Larsen, C: 1 article (09/2009)
9.	Grønhøj Larsen, F: 1 article (09/2009)
10.	Heidenheim, M: 1 article (09/2009)

Related Diseases

1.	Acne Vulgaris 01/01/1998 - "The aim of this study was to investigate the plasma levels of isotretinoin and of 4-oxo-isotretinoin over long-term treatment of severe acne and to assess any correlation with the given dose, the clinical improvement and the occurrence of side effects. " 04/01/1990 - "An investigation of pooled skin samples from 22 acne patients has shown that isotretinoin and its major metabolite, 4-oxo-isotretinoin, can be detected in sebaceous glands during treatment with isotretinoin (1 mg/kg/d for 4 months). " 01/01/1983 - "The multiple dose pharmacokinetics of isotretinoin and its major blood metabolite, 4-oxo-isotretinoin, were studied in 10 patients with cystic acne and 11 patients with various keratinization disorders. " 09/01/2009 - "To determine if isotretinoin (13-cis-RA), its main metabolite 4-oxo-isotretinoin (4-oxo-13-cis-RA), and other possible metabolites in the presence or absence of ethanol are converted to their corresponding ethyl derivatives in patients with severe acne or rosacea after multiple isotretinoin dosing. "
2.	Teratogenesis 08/01/1987 - "In human volunteers and patients, one major blood metabolite of IT is 4-oxo-isotretinoin (4-oxo-IT) which undergoes slower elimination than IT and may itself be a participant in teratogenesis. "
3.	Rosacea (Acne Rosacea) 09/01/2009 - "To determine if isotretinoin (13-cis-RA), its main metabolite 4-oxo-isotretinoin (4-oxo-13-cis-RA), and other possible metabolites in the presence or absence of ethanol are converted to their corresponding ethyl derivatives in patients with severe acne or rosacea after multiple isotretinoin dosing. "
4.	Papilloma (Papillomatosis) 09/16/1994 - "Some of these 4-oxoretinoic acid analogues showed high activity in assays in vivo for the inhibition of ornithine decarboxylase activity and carcinogen-induced papillomas in mouse skin."
5.	Neuroblastoma 12/01/2014 - "Metabolic characteristics of 13-cis-retinoic acid (isotretinoin) and anti-tumour activity of the 13-cis-retinoic acid metabolite 4-oxo-13-cis-retinoic acid in neuroblastoma."

Related Drugs and Biologics

1.	Isotretinoin (Accutane)
2.	Ornithine Decarboxylase (Decarboxylase, Ornithine)
3.	Carcinogens
4.	Calcium
5.	Ethanol (Ethyl Alcohol)