|1.||Paschke, Reinhard: 10 articles (01/2015 - 06/2010)|
|2.||Safe, Stephen: 7 articles (12/2014 - 03/2007)|
|3.||Fulda, Simone: 7 articles (01/2014 - 10/2004)|
|4.||Lee, Kuo-Hsiung: 4 articles (05/2015 - 07/2009)|
|5.||Jutooru, Indira: 4 articles (12/2014 - 11/2007)|
|6.||Debatin, Klaus-Michael: 4 articles (02/2013 - 10/2004)|
|7.||Chen, Yan: 4 articles (12/2012 - 12/2008)|
|8.||He, Jing: 4 articles (12/2012 - 12/2008)|
|9.||Kommera, Harish: 4 articles (04/2011 - 06/2010)|
|10.||Medema, Jan Paul: 4 articles (03/2011 - 06/2007)|
01/01/2014 - "This study provides evidence that betulinic acid is highly effective against the human cervical cancer cell line HeLa by inducing dose- and time-dependent apoptosis. "
06/18/2007 - "Broad in vitro efficacy of plant-derived betulinic acid against cell lines derived from the most prevalent human cancer types."
01/09/2009 - "Betulinic acid (BA) has anti cancer and anti-HIV activity and has been proved to be therapeutically effective against cancerous and HIV-infected cells. "
01/01/2014 - "The study revealed the beneficial influence of betulinic acid inclusion into the cyclodextrin in terms of antiproliferative activity and in vivo tumor development. "
05/01/2013 - "Chemical transformation studies carried out on betulinic acid, through concise 1,2,3-triazole synthesis via click chemistry approach at C-3position in ring A have been evaluated for their cytotoxic potentiation against nine human cancer cell lines. "
|2.||Melanoma (Melanoma, Malignant)
09/01/2005 - "This study was designed to investigate the cell signaling pathway leading human melanoma cells to increased resistance to betulinic acid treatment. "
12/01/2002 - "This study investigates the regulation and expression of Mcl-1 in human melanoma cells, which was recently found to be induced by betulinic acid, a compound with anti-melanoma and apoptosis-inducing potential. "
01/01/2014 - "Betulinic acid, a very promising anti-melanoma agent, has very low water solubility that causes low bioavailability. "
06/01/2013 - "Betulinic acid suppresses NGAL-induced epithelial-to-mesenchymal transition in melanoma."
07/01/2009 - "Betulinic acid exhibits stronger cytotoxic activity on the normal melanocyte NHEM-neo cell line than on drug-resistant and drug-sensitive MeWo melanoma cell lines."
04/01/2004 - "Recently, considerable in vitro evidence has demonstrated that betulinic acid is effective against small- and non-small-cell lung, ovarian, cervical, and head and neck carcinomas. "
09/18/2015 - "Synthesis and biological evaluation of a novel betulinic acid derivative as an inducer of apoptosis in human colon carcinoma cells (HT-29)."
01/01/2015 - "Betulinic acid selectively inhibits the growth of ovarian carcinoma cell lines without affecting the normal cells. "
01/01/2013 - "Betulinic acid (BA) is a natural product that exerts its cytotoxicity against various malignant carcinomas without side effects by triggering the mitochondrial pathway to apoptosis. "
08/01/2012 - "Betulinic acid exerts immunoregulation and anti-tumor effect on cervical carcinoma (U14) tumor-bearing mice."
|4.||Prostatic Neoplasms (Prostate Cancer)
01/01/2013 - "Betulinic acid selectively increases protein degradation and enhances prostate cancer-specific apoptosis: possible role for inhibition of deubiquitinase activity."
01/01/2011 - "Suppression of STAT3 and HIF-1 alpha mediates anti-angiogenic activity of betulinic acid in hypoxic PC-3 prostate cancer cells."
01/01/2011 - "In the present study, we examined that betulinic acid (BA), a triterpene from the bark of white birch, had the inhibitory effects on hypoxia-mediated activation of STAT3 in androgen independent human prostate cancer PC-3 cells. "
12/01/2008 - "In this study we examined whether betulinic acid (BetA), a pentacyclic triterpene from the bark of white birch, is effective in inhibiting NF-kappaB expression in androgen-refractory human prostate cancer cells exhibiting high constitutive NF-kappaB expression. "
03/15/2007 - "Using LNCaP prostate cancer cells as a model, we now show that betulinic acid decreases expression of vascular endothelial growth (VEGF) and the antiapoptotic protein survivin. "
|5.||Neuroectodermal Tumors (Neuroectodermal Tumor)
12/01/2000 - "Betulinic acid induces apoptosis through a direct effect on mitochondria in neuroectodermal tumors."
07/01/1999 - "Betulinic acid: a new chemotherapeutic agent in the treatment of neuroectodermal tumors."
01/10/2002 - "These data support further preclinical studies of betulinic acid not confined to melanoma and neuroectodermal tumors independently of p53 status."
01/01/2006 - "Betulinic acid (BA), a pentacyclic triterpene of natural origin, effectively induces apoptosis in neuroectodermal tumors and was recently shown to be a potent trigger of cell death in human leukemia-derived cell lines. "
07/01/2003 - "Betulinic acid, a naturally occurring triterpene found in the bark of the white birch tree, has been demonstrated to induce programmed cell death with melanoma and certain neuroectodermal tumor cells. "
|3.||NF-kappa B (NF-kB)
|8.||Etoposide (VP 16)
|10.||Ethanol (Ethyl Alcohol)
|3.||Complementary Therapies (Alternative Medicine)
|5.||Heterologous Transplantation (Xenotransplantation)