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5-fluorouridine

irreversible inhibitor of ribosomal RNA biosynthesis; RN given refers to unlabeled cpd
Also Known As:
5-fluorouridine, 18F-labeled
Networked: 86 relevant articles (7 outcomes, 6 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Bonaterra, Gabriel A: 3 articles (04/2019 - 12/2013)
2. Kinscherf, Ralf: 3 articles (04/2019 - 12/2013)
3. Rosemeyer, Helmut: 3 articles (04/2019 - 12/2013)
4. Hu, Nan: 2 articles (12/2017 - 01/2017)
5. Li, Ru-Tian: 2 articles (12/2017 - 07/2015)
6. Liu, Qin: 2 articles (01/2017 - 07/2015)
7. Farhat, Anisa: 2 articles (03/2014 - 12/2013)
8. Malecki, Edith: 2 articles (03/2014 - 12/2013)
9. Röthlein, Doris: 2 articles (03/2014 - 12/2013)
10. Schmitt, Jürgen: 2 articles (03/2014 - 12/2013)

Related Diseases

1. Neoplasms (Cancer)
2. Colorectal Neoplasms (Colorectal Cancer)
01/01/1992 - "To study the difference in the efficacy of this combination against different tumors, we compared the effect of LV (20 microM) on the cytotoxicity of FUra, FdUrd, and 5-fluorouridine (FUrd) in vitro against cell lines of five colorectal carcinomas (CC), five gastric carcinomas (GC), and four non-small-cell lung carcinomas (NSCLC) using the colony-forming assay. "
08/01/2005 - "HCT-116 colorectal carcinoma cells were exposed to 10 microM 5-fluorouridine alone or in the presence of 1 mM uridine, 30 microM thymidine or both uridine and thymidine. "
05/01/2009 - "Here, we present a novel therapeutic approach to circumvent clinical resistance to bolus 5-FU, that is, treatment of bolus 5-FU-resistant colorectal cancer cells with low-dose 5-azadeoxycytidine (DAC), an inhibitor of DNA hypermethylation, restored sensitivity to 5-FU as well as 5-fluorouridine. "
01/01/1988 - "To determine the optimal concentration time factors for the fluoropyrimidines 5-fluorouracil (FU), 5-fluorouridine (FUR), and 5-fluoro-2'-deoxyuridine (FUdR) in regional chemotherapy, we tested these drugs against the colorectal carcinoma cell line HT 29 at various dosages and exposure times. "
10/10/2021 - "To facilitate improved tumour-targeting of this drug combination, an ultrasound responsive microbubble formulation loaded with 5-fluorouridine, irinotecan and oxaliplatin (FIRINOX MB) was developed and its efficacy tested, together with the non-toxic folinic acid, in preclinical murine models of pancreatic and colorectal cancer. "
3. Carcinoma (Carcinomatosis)
4. Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung)
5. Urinary Bladder Neoplasms (Bladder Cancer)

Related Drugs and Biologics

1. Fluorouracil (Carac)
2. Azauridine (6 Azauridine)
3. pyrimidine
4. Polymers
5. Dihydrouracil Dehydrogenase (NADP) (Dihydropyrimidine Dehydrogenase)
6. Drug Combinations
7. Leucovorin (Folinic Acid)
8. Amino Sugars
9. Oxaliplatin (Eloxatin)
10. Irinotecan (Camptosar)

Related Therapies and Procedures

1. Microbubbles
2. Drug Therapy (Chemotherapy)
3. Therapeutics
4. Filtering Surgery
5. Aftercare (After-Treatment)