nonachlor

component of technical chlordan & heptachlor; RN given refers to cpd without isomeric designation

Also Known As:

1,2,3,4,5,6,7,8,8-nonachloro-3a,4,7,7a- tetrahydro-4,7-methanoindan; nonachlor, (cis)-isomer; nonachlor, (trans)-isomer

Networked: 33 relevant articles (0 outcomes, 6 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Halogenated Hydrocarbons: 42
    - Chlorinated Hydrocarbons: 240
      - nonachlor: 33

Experts

1.	Klebanoff, Mark A: 3 articles (07/2014 - 03/2012)
2.	Longnecker, Matthew P: 3 articles (07/2014 - 03/2012)
3.	Antignac, Jean-Philippe: 2 articles (01/2022 - 05/2020)
4.	Cano-Sancho, German: 2 articles (01/2022 - 05/2020)
5.	Cariou, Véronique: 2 articles (01/2022 - 05/2020)
6.	Kiviranta, Hannu: 2 articles (01/2022 - 09/2011)
7.	Le Bizec, Bruno: 2 articles (01/2022 - 05/2020)
8.	Matta, Komodo: 2 articles (01/2022 - 05/2020)
9.	Ploteau, Stéphane: 2 articles (01/2022 - 05/2020)
10.	Rantakokko, Panu: 2 articles (01/2022 - 09/2011)

Related Diseases

1.	Body Weight (Weight, Body) 12/01/2000 - "In this study, rats were administered cis-nonachlor, trans-nonachlor, or technical chlordane by gavage for 28 days at doses of 0.25 to 25 mg/kg body weight. " 05/01/2001 - "2) Cis- or trans-nonachlor (0, 0.25, 2.5, 25 mg/kg body weight) were administered daily in corn oil to male rats by gavage for 28 days. " 11/26/2005 - "Thus, comparative tissue depletion studies were undertaken in male and female rats exposed to trans-nonachlor, oxychlordane, or trans-chlordane at 2.5 mg/kg body weight/d by gavage for 28 d followed by two consecutive 28-d depletion periods. "
2.	Breast Neoplasms (Breast Cancer) 01/01/2000 - "Oxychlordane and trans-nonachlor in breast adipose tissue and risk of female breast cancer." 07/01/2009 - "Rather, higher serum levels of cis-nonachlor, mirex, or total PCBs were associated with a decreased risk of breast cancer Overall, these results suggest that breast cancer risk in Japan, a low-incidence country, is similar to that in western countries in terms of organochlorine exposure." 01/01/2000 - "This paper examines the hypothesis that environmental exposure to trans-nonachlor (TNC) and oxychlordane (OCD), a major metabolite of the insecticide chlordane, increases the A total of 304 histologically confirmed, incident primary breast-cancer patients and 186 histologically confirmed incident benign breast-disease controls were included in the study between 1994 and 1997. " 07/01/2009 - "No increase in the risk of breast cancer was seen among women with higher serum concentrations of any organochlorine: o,p'-DDT, p,p'-DDT, p,p'-dichlorodiphenyldichloroethylene, hexachlorobenzene, beta-hexachlorocyclohexane, trans-nonachlor, cis-nonachlor, oxychlordane, mirex, or PCBs. "
3.	Atherosclerosis 01/01/2016 - "However, occurrence of atherosclerosis was found to be associated with serum trans-nonachlor levels. " 01/01/2016 - "The association of serum trans-nonachlor levels with atherosclerosis." 01/01/2016 - "In the current study, urinary concentrations of F2-isoprostanes and serum levels of persistent OC compounds p,p'-dichlorodiphenyldichloroethene (DDE), trans-nonachlor (a component of the technical chlordane mixture), and oxychlordane (a chlordane metabolite) were quantified in a cross-sectional study sample and the association of these factors with a clinical diagnosis of atherosclerosis determined. "
4.	Testicular Neoplasms (Testicular Cancer) 05/07/2008 - "To study the relationship of POP exposure to TGCT risk, prediagnostic serum samples from 754 case subjects and 928 control subjects enrolled in the Servicemen's Testicular Tumor Environmental and Endocrine Determinants Study were analyzed for cis-nonachlor, trans-nonachlor, oxychlordane, total chlordanes, beta-hexachlorocyclohexane, mirex, p,p'-dichlorodiphenyldichloroethylene (p,p'-DDE), and p,p'-dichlorodiphenyltrichloroethane. "
5.	Metabolic Diseases (Metabolic Disease) 06/01/2020 - "Given the recent data implicating exposure to persistent organic pollutants (POPs) in the pathogenesis of metabolic diseases, the current study was designed to examine the effects of the highly implicated organochlorine (OC) compounds oxychlordane and trans-nonachlor on overall macrophage function. " 06/01/2020 - "However, both oxychlordane and trans-nonachlor decreased basal expression of the M1 pro-inflammatory marker cyclooxygenase 2. Taken together, these data indicate that exposure to these two OC compounds have both compound and concentration dependent effects on macrophage function which may alter both the innate immune response and impact metabolic function of key organs involved in metabolic diseases."

Related Drugs and Biologics

1.	oxychlordane
2.	Chlordan (Chlordane)
3.	Dichlorodiphenyl Dichloroethylene (DDE)
4.	Mirex
5.	beta-hexachlorocyclohexane
6.	Persistent Organic Pollutants
7.	F2-Isoprostanes (F2 Isoprostanes)
8.	Insecticides
9.	Polychlorinated Biphenyls (PCBs)
10.	DDT