diacetoxyscirpenol

mycotoxin belonging to 12,13-epoxytrichothecene group; RN given refers to (3alpha,4beta)-isomer; structure

Also Known As:

4,15-di-o-acetylscirpenol; 4,15-diacetoxyscirp-9-en-3-ol; 4,15-diacetoxyscirpen-3-ol; NSC 141537; anguidin; anguidine; trichothec-9-ene-3alpha, 4beta, 15-triol, 12,13-epoxy-, 4,15-diacetate

Networked: 47 relevant articles (1 outcomes, 11 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Wu, Wenda: 4 articles (01/2020 - 01/2017)
2.	Kuca, Kamil: 3 articles (01/2020 - 12/2017)
3.	Wu, Qinghua: 3 articles (01/2020 - 12/2017)
4.	Nepovimova, Eugenie: 2 articles (01/2020 - 12/2017)
5.	Zhang, Haibin: 2 articles (11/2017 - 01/2017)
6.	Zhang, Jie: 2 articles (11/2017 - 01/2017)
7.	Adel Rad, Khoda Berdi: 1 article (01/2021)
8.	Barba, Francisco J: 1 article (01/2021)
9.	Berrada, Houda: 1 article (01/2021)
10.	Escrivá, Laura: 1 article (01/2021)

Related Diseases

1.	Leukemia P388 07/01/1985 - "In in vivo tests against P388 leukemia, most of them showed an improved activity compared to anguidin though their potency was decreased. "
2.	Neoplasms (Cancer) 02/01/1984 - "Anguidine: a broad phase II study of the Southeastern Cancer Study Group." 02/01/1982 - "The Southwest Oncology Group conducted a phase II study of anguidine in 134 patients with gastrointestinal malignancies. " 02/01/1982 - "Phase II study of anguidine in gastrointestinal malignancies: a Southwest Oncology Group study." 09/20/2016 - "Overall, diacetoxyscirpenol is considered a potential drug deregulating the HIF-1 signaling pathway, and it could be beneficially employed for treating malignant tumors with hypoxic microenvironment." 09/20/2016 - "More importantly, diacetoxyscirpenol retarded tumor growth in mice, and reduced HIF-1α expression and vascular formation in the tumors. "
3.	Colonic Neoplasms (Colon Cancer) 10/01/1978 - "Because of disappointing results in clinical trials, we analyzed the lethal and cytokinetic effects of anguidine on cultured human colon cancer cells. " 10/01/1978 - "Tumoricidal activity of anguidine in a cultured human colon cancer line is poor and requires prolonged exposure. " 10/01/1978 - "Anguidine is a fungal metabolite with antitumor activity in a murine colon cancer model. " 10/01/1978 - "Lethal and cytokinetic effects of anguidine on a human colon cancer cell line." 02/01/1982 - "Antitumor activity of anguidine in patients with colon cancer may be similar to that of 5-FU, but nonhematologic toxicity is substantial."
4.	Anorexia 01/01/2017 - "Role of Peptide YY3-36 and Glucose-Dependent Insulinotropic Polypeptide in Anorexia Induction by Trichothecences T-2 Toxin, HT-2 Toxin, Diacetoxyscirpenol, and Neosolaniol." 01/01/2017 - "In this study, we hypothesized that anorexia induced by type A trichothecenes, including T-2 toxin (T-2), HT-2 toxin (HT-2), diacetoxyscirpenol (DAS), and neosolaniol (NEO), in mice corresponds to the changes in the gut satiety hormones peptide YY3-36 (PYY3-36) and glucose-dependent insulinotropic polypeptide (GIP) in plasma. " 11/15/2017 - "Gut satiety hormones cholecystokinin and glucagon-like Peptide-17-36 amide mediate anorexia induction by trichothecenes T-2 toxin, HT-2 toxin, diacetoxyscirpenol and neosolaniol."
5.	Central Nervous System Neoplasms 03/01/1983 - "Phase II evaluation of anguidine in central nervous system tumors: a southwest Oncology Group study."

Related Drugs and Biologics

1.	amsonic acid (DAS)
2.	T-2 Toxin (T 2 Toxin)
3.	neosolaniol
4.	HT-2 toxin
5.	Fluorouracil (Carac)
6.	Peptide Hormones (Polypeptide Hormones)
7.	Peptides (Polypeptides)
8.	Glucose (Dextrose)
9.	Cisplatin (Platino)
10.	Antineoplastic Agents (Antineoplastics)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Intravenous Administration
3.	Therapeutics